An SPR Microfluidic Devices for Identification of Human Herpesvirus 4 And SARS-Cov-2

Han Yun Hsieh; Ray Chang; Er Yuan Chuang; Yu Jui Fan; Pei Kuen Wei; Horn Jiunn Sheen

An SPR Microfluidic Devices for Identification of Human Herpesvirus 4 And SARS-Cov-2

Han Yun Hsieh
, Ray Chang
, Er Yuan Chuang
, Yu Jui Fan
, Pei Kuen Wei
, Horn Jiunn Sheen

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Recent studies reveal that the severity of COVID-19 may be correlated with the presence of HHV-4. Although numerous devices can detect HHV-4 or SARS-CoV-2, to our knowledge, no device has been used to detect both simultaneously.Herein, we design a device that can perform a duplex polymerase chain reaction (PCR) in a microfluidic channel and detect amplicons through a surface plasmon resonance (SPR) sensor. This device can reduce the required PCR time by 55% compared to traditional instruments while yielding a similar amount of amplicon. Moreover, the device can detect desired genes by extracting cells infected with HHV-4/SARS-CoV-2.

Original language	English
Title of host publication	2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	987-989
Number of pages	3
ISBN (Electronic)	9784886864352
Publication status	Published - 2023
Event	22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023 - Kyoto, Japan Duration: Jun 25 2023 → Jun 29 2023

Publication series

Name	2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023

Conference

Conference	22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023
Country/Territory	Japan
City	Kyoto
Period	6/25/23 → 6/29/23

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

duplex PCR
human herpesvirus 4
label-free
nanoslit-based plasmonics
polymerase chain reaction
SARS-CoV-2

ASJC Scopus subject areas

Computer Science Applications
Electrical and Electronic Engineering
Control and Optimization
Instrumentation

Cite this

Hsieh, H. Y., Chang, R., Chuang, E. Y., Fan, Y. J., Wei, P. K., & Sheen, H. J. (2023). An SPR Microfluidic Devices for Identification of Human Herpesvirus 4 And SARS-Cov-2. In 2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023 (pp. 987-989). (2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023). Institute of Electrical and Electronics Engineers Inc..

An SPR Microfluidic Devices for Identification of Human Herpesvirus 4 And SARS-Cov-2. / Hsieh, Han Yun; Chang, Ray; Chuang, Er Yuan et al.
2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023. Institute of Electrical and Electronics Engineers Inc., 2023. p. 987-989 (2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Hsieh, HY, Chang, R, Chuang, EY, Fan, YJ, Wei, PK & Sheen, HJ 2023, An SPR Microfluidic Devices for Identification of Human Herpesvirus 4 And SARS-Cov-2. in 2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023. 2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023, Institute of Electrical and Electronics Engineers Inc., pp. 987-989, 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023, Kyoto, Japan, 6/25/23.

Hsieh HY, Chang R, Chuang EY, Fan YJ, Wei PK, Sheen HJ. An SPR Microfluidic Devices for Identification of Human Herpesvirus 4 And SARS-Cov-2. In 2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023. Institute of Electrical and Electronics Engineers Inc. 2023. p. 987-989. (2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023).

Hsieh, Han Yun ; Chang, Ray ; Chuang, Er Yuan et al. / An SPR Microfluidic Devices for Identification of Human Herpesvirus 4 And SARS-Cov-2. 2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023. Institute of Electrical and Electronics Engineers Inc., 2023. pp. 987-989 (2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023).

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title = "An SPR Microfluidic Devices for Identification of Human Herpesvirus 4 And SARS-Cov-2",

abstract = "Recent studies reveal that the severity of COVID-19 may be correlated with the presence of HHV-4. Although numerous devices can detect HHV-4 or SARS-CoV-2, to our knowledge, no device has been used to detect both simultaneously.Herein, we design a device that can perform a duplex polymerase chain reaction (PCR) in a microfluidic channel and detect amplicons through a surface plasmon resonance (SPR) sensor. This device can reduce the required PCR time by 55\% compared to traditional instruments while yielding a similar amount of amplicon. Moreover, the device can detect desired genes by extracting cells infected with HHV-4/SARS-CoV-2.",

keywords = "duplex PCR, human herpesvirus 4, label-free, nanoslit-based plasmonics, polymerase chain reaction, SARS-CoV-2",

author = "Hsieh, \{Han Yun\} and Ray Chang and Chuang, \{Er Yuan\} and Fan, \{Yu Jui\} and Wei, \{Pei Kuen\} and Sheen, \{Horn Jiunn\}",

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T1 - An SPR Microfluidic Devices for Identification of Human Herpesvirus 4 And SARS-Cov-2

AU - Hsieh, Han Yun

AU - Chang, Ray

AU - Chuang, Er Yuan

AU - Fan, Yu Jui

AU - Wei, Pei Kuen

AU - Sheen, Horn Jiunn

PY - 2023

Y1 - 2023

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AB - Recent studies reveal that the severity of COVID-19 may be correlated with the presence of HHV-4. Although numerous devices can detect HHV-4 or SARS-CoV-2, to our knowledge, no device has been used to detect both simultaneously.Herein, we design a device that can perform a duplex polymerase chain reaction (PCR) in a microfluidic channel and detect amplicons through a surface plasmon resonance (SPR) sensor. This device can reduce the required PCR time by 55% compared to traditional instruments while yielding a similar amount of amplicon. Moreover, the device can detect desired genes by extracting cells infected with HHV-4/SARS-CoV-2.

KW - duplex PCR

KW - human herpesvirus 4

KW - label-free

KW - nanoslit-based plasmonics

KW - polymerase chain reaction

KW - SARS-CoV-2

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M3 - Conference contribution

AN - SCOPUS:85193479304

T3 - 2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023

SP - 987

EP - 989

BT - 2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023

PB - Institute of Electrical and Electronics Engineers Inc.

T2 - 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023

Y2 - 25 June 2023 through 29 June 2023

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An SPR Microfluidic Devices for Identification of Human Herpesvirus 4 And SARS-Cov-2

Abstract

Publication series

Conference

UN SDGs

Keywords

ASJC Scopus subject areas

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Cite this