Abstract
Cancer of the parotid gland is relatively rare, but carries poor prognosis owing to its prevailing distant metastases. In addition to the disease's basic epidemiology and pathology, we review some current discoveries of its tumorigenesis molecular mechanism. Based on published salivary gland cancer clinical trial data, non-surgical antitumor efficacies amongst a range of chemotherapy, radiation, and concurrent therapy regimens are compared. We also present the current development status of novel radiation therapy and targeted therapeutics, focusing on intensity-modulated radiation therapy (IMRT), and epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) blockages, which are showing promise for improving parotid gland cancer management.
| Original language | English |
|---|---|
| Article number | 40 |
| Journal | Head and Neck Oncology |
| Volume | 3 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Dec 1 2011 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Parotid gland cancer
- endosomal sorting complexes required for transport
- epidermal growth factor receptor
- multi-vesicular bodies
- salivary gland cancer
- targeted therapeutics
- vacuolar protein sorting-associated protein 4B
- vascular endothelial growth factor
ASJC Scopus subject areas
- Otorhinolaryngology
- Oncology
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