An integrin binding-defective mutant of insulin-like growth factor-1 (R36E/R37E IGF1) acts as a dominant-negative antagonist of the IGF1 receptor (IGF1R) and suppresses tumorigenesis but still binds to IGF1R

Masaaki Fujita, Katsuaki Ieguchi, Dora M. Cedano-Prieto, Andrew Fong, Charles Wilkerson, Jane Q. Chen, Mac Wu, Su Hao Lo, Anthony T.W. Cheung, MacHelle D. Wilson, Robert D. Cardiff, Alexander D. Borowsky, Yoko K. Takada, Yoshikazu Takada

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Biochemistry, Genetics and Molecular Biology