An innovative three-dimensional printed titanium implant with a biomimetic structure design for promoting osseointegration potential

Taufik Abdullah Mappa, Shu Fen Chu, Kuo Sheng Hung, Takashi Saito, Muhammad Ruslin, Wen Chien Lan, Hsin Hui Kuo, Yung Chieh Cho, Chia Chien Hsieh, Jonathan Huang, Yung Kang Shen, Keng Liang Ou

Research output: Contribution to journalArticlepeer-review

Abstract

The present study aimed to investigate the surface characteristic, biocompatibility, and bone regeneration behavior of an innovative three-dimensional (3D) printed titanium (Ti) implant with a biomimetic cancellous bone-like spherical particle porous structure (3DBCP-Ti) through scanning electron microscopy, X-ray diffractometry, static contact angle goniometry, cytotoxicity assay, and rabbit model. The analytical results showed that the 3DBCP-Ti implant with an average pore size of 400 ± 10.5 μm can be fabricated using a selective laser sintering method. The 3DBCP-Ti implant not only possessed excellent wettability (13.5 ± 1.7°) but also presented superior cell viability (97 ± 1.5 %) in vitro. After implantation for 4 weeks, the bone mineral density of the 3DBCP-Ti implant (0.14 ± 0.02 mg/cm3) exhibited a slightly higher value than the control implant (0.13 ± 0.03 mg/cm3). Moreover, histological results also indicated that the new bone formation area of the 3DBCP-Ti implant (43.9 ± 7.0 %, *p < 0 0.05) significantly enhanced as compared with the control (23.5 ± 4.6 %) and blank (18.2 ± 1.4 %) groups at week 12 post-implantation. Accordingly, these findings demonstrate that the innovative 3DBCP-Ti implant has the potential to promote osseointegration at early-stage implantation for dental, orthopedic, and neurosurgical applications.

Original languageEnglish
Article number112692
JournalMaterials and Design
Volume238
DOIs
Publication statusPublished - Feb 2024

Keywords

  • Biocompatibility
  • Cancellous bone-like porous implant
  • Osseointegration
  • Selective laser 3D printing
  • Surface characteristic

ASJC Scopus subject areas

  • General Materials Science
  • Mechanics of Materials
  • Mechanical Engineering

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