TY - JOUR
T1 - An innovative three-dimensional printed titanium implant with a biomimetic structure design for promoting osseointegration potential
AU - Mappa, Taufik Abdullah
AU - Chu, Shu Fen
AU - Hung, Kuo Sheng
AU - Saito, Takashi
AU - Ruslin, Muhammad
AU - Lan, Wen Chien
AU - Kuo, Hsin Hui
AU - Cho, Yung Chieh
AU - Hsieh, Chia Chien
AU - Huang, Jonathan
AU - Shen, Yung Kang
AU - Ou, Keng Liang
N1 - Publisher Copyright:
© 2024
PY - 2024/2
Y1 - 2024/2
N2 - The present study aimed to investigate the surface characteristic, biocompatibility, and bone regeneration behavior of an innovative three-dimensional (3D) printed titanium (Ti) implant with a biomimetic cancellous bone-like spherical particle porous structure (3DBCP-Ti) through scanning electron microscopy, X-ray diffractometry, static contact angle goniometry, cytotoxicity assay, and rabbit model. The analytical results showed that the 3DBCP-Ti implant with an average pore size of 400 ± 10.5 μm can be fabricated using a selective laser sintering method. The 3DBCP-Ti implant not only possessed excellent wettability (13.5 ± 1.7°) but also presented superior cell viability (97 ± 1.5 %) in vitro. After implantation for 4 weeks, the bone mineral density of the 3DBCP-Ti implant (0.14 ± 0.02 mg/cm3) exhibited a slightly higher value than the control implant (0.13 ± 0.03 mg/cm3). Moreover, histological results also indicated that the new bone formation area of the 3DBCP-Ti implant (43.9 ± 7.0 %, *p < 0 0.05) significantly enhanced as compared with the control (23.5 ± 4.6 %) and blank (18.2 ± 1.4 %) groups at week 12 post-implantation. Accordingly, these findings demonstrate that the innovative 3DBCP-Ti implant has the potential to promote osseointegration at early-stage implantation for dental, orthopedic, and neurosurgical applications.
AB - The present study aimed to investigate the surface characteristic, biocompatibility, and bone regeneration behavior of an innovative three-dimensional (3D) printed titanium (Ti) implant with a biomimetic cancellous bone-like spherical particle porous structure (3DBCP-Ti) through scanning electron microscopy, X-ray diffractometry, static contact angle goniometry, cytotoxicity assay, and rabbit model. The analytical results showed that the 3DBCP-Ti implant with an average pore size of 400 ± 10.5 μm can be fabricated using a selective laser sintering method. The 3DBCP-Ti implant not only possessed excellent wettability (13.5 ± 1.7°) but also presented superior cell viability (97 ± 1.5 %) in vitro. After implantation for 4 weeks, the bone mineral density of the 3DBCP-Ti implant (0.14 ± 0.02 mg/cm3) exhibited a slightly higher value than the control implant (0.13 ± 0.03 mg/cm3). Moreover, histological results also indicated that the new bone formation area of the 3DBCP-Ti implant (43.9 ± 7.0 %, *p < 0 0.05) significantly enhanced as compared with the control (23.5 ± 4.6 %) and blank (18.2 ± 1.4 %) groups at week 12 post-implantation. Accordingly, these findings demonstrate that the innovative 3DBCP-Ti implant has the potential to promote osseointegration at early-stage implantation for dental, orthopedic, and neurosurgical applications.
KW - Biocompatibility
KW - Cancellous bone-like porous implant
KW - Osseointegration
KW - Selective laser 3D printing
KW - Surface characteristic
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U2 - 10.1016/j.matdes.2024.112692
DO - 10.1016/j.matdes.2024.112692
M3 - Article
AN - SCOPUS:85183204788
SN - 0264-1275
VL - 238
JO - Materials and Design
JF - Materials and Design
M1 - 112692
ER -