An innovative bioceramic bone graft with platelet-rich plasma for rapid bone healing and regeneration in a rabbit model

Syamsiah Syam; Chun Wei Chang; Wen Chien Lan; Keng Liang Ou; Bai Hung Huang; Yu Yeong Lin; Takashi Saito; Hsin Yu Tsai; Yen Chun Chuo; Tzu Sen Yang; Chung Ming Liu; Ping Jen Hou

doi:10.3390/app11115271

An innovative bioceramic bone graft with platelet-rich plasma for rapid bone healing and regeneration in a rabbit model

Syamsiah Syam, Chun Wei Chang, Wen Chien Lan, Keng Liang Ou, Bai Hung Huang, Yu Yeong Lin, Takashi Saito, Hsin Yu Tsai, Yen Chun Chuo, Tzu Sen Yang, Chung Ming Liu, Ping Jen Hou

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

This study aimed to investigate the effect of combining an innovative bioceramic α-calcium sulfate hemihydrate (α-CSH, CaSO₄·0.5H₂O) bone graft and platelet-rich plasma (PRP) to accelerate bone healing and regeneration in a rabbit model. The bone graft material was implanted bilaterally on rabbit’s artificially maxillary sinus defects: the right maxillary sinus received α-CSH, while α-CSH combine with PRP (α-CSH/PRP) was grafted in left site. The quantity and quality of bone formation after implantation were analyzed radiographically and histologically at 1, 2, and 3 weeks. The micro-computed tomographic results indicated that the bone density of sinus implanted with α-CSH increased and defect volume decreased most after 2 weeks. In histological analysis, both hematoxylin and eosin and Masson trichrome staining of α-CSH/PRP displays better bone healing and regeneration progress than α-CSH after 2 weeks implantation. Therefore, the innovative α-CSH combined with PRP was revealed to be useful in accelerating bone healing and regeneration for the successful defect treatment.

Original language	English
Article number	5271
Journal	Applied Sciences (Switzerland)
Volume	11
Issue number	11
DOIs	https://doi.org/10.3390/app11115271
Publication status	Published - Jun 1 2021

Keywords

Bioceramic bone graft
Bone healing
Bone regeneration
Platelet-rich plasma
α-calcium sulfate hemihydrate

ASJC Scopus subject areas

General Materials Science
Instrumentation
General Engineering
Process Chemistry and Technology
Computer Science Applications
Fluid Flow and Transfer Processes

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10.3390/app11115271

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title = "An innovative bioceramic bone graft with platelet-rich plasma for rapid bone healing and regeneration in a rabbit model",

abstract = "This study aimed to investigate the effect of combining an innovative bioceramic α-calcium sulfate hemihydrate (α-CSH, CaSO4·0.5H2O) bone graft and platelet-rich plasma (PRP) to accelerate bone healing and regeneration in a rabbit model. The bone graft material was implanted bilaterally on rabbit{\textquoteright}s artificially maxillary sinus defects: the right maxillary sinus received α-CSH, while α-CSH combine with PRP (α-CSH/PRP) was grafted in left site. The quantity and quality of bone formation after implantation were analyzed radiographically and histologically at 1, 2, and 3 weeks. The micro-computed tomographic results indicated that the bone density of sinus implanted with α-CSH increased and defect volume decreased most after 2 weeks. In histological analysis, both hematoxylin and eosin and Masson trichrome staining of α-CSH/PRP displays better bone healing and regeneration progress than α-CSH after 2 weeks implantation. Therefore, the innovative α-CSH combined with PRP was revealed to be useful in accelerating bone healing and regeneration for the successful defect treatment.",

keywords = "Bioceramic bone graft, Bone healing, Bone regeneration, Platelet-rich plasma, α-calcium sulfate hemihydrate",

author = "Syamsiah Syam and Chang, {Chun Wei} and Lan, {Wen Chien} and Ou, {Keng Liang} and Huang, {Bai Hung} and Lin, {Yu Yeong} and Takashi Saito and Tsai, {Hsin Yu} and Chuo, {Yen Chun} and Yang, {Tzu Sen} and Liu, {Chung Ming} and Hou, {Ping Jen}",

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AU - Syam, Syamsiah

AU - Chang, Chun Wei

AU - Lan, Wen Chien

AU - Ou, Keng Liang

AU - Huang, Bai Hung

AU - Lin, Yu Yeong

AU - Saito, Takashi

AU - Tsai, Hsin Yu

AU - Chuo, Yen Chun

AU - Yang, Tzu Sen

AU - Liu, Chung Ming

AU - Hou, Ping Jen

PY - 2021/6/1

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N2 - This study aimed to investigate the effect of combining an innovative bioceramic α-calcium sulfate hemihydrate (α-CSH, CaSO4·0.5H2O) bone graft and platelet-rich plasma (PRP) to accelerate bone healing and regeneration in a rabbit model. The bone graft material was implanted bilaterally on rabbit’s artificially maxillary sinus defects: the right maxillary sinus received α-CSH, while α-CSH combine with PRP (α-CSH/PRP) was grafted in left site. The quantity and quality of bone formation after implantation were analyzed radiographically and histologically at 1, 2, and 3 weeks. The micro-computed tomographic results indicated that the bone density of sinus implanted with α-CSH increased and defect volume decreased most after 2 weeks. In histological analysis, both hematoxylin and eosin and Masson trichrome staining of α-CSH/PRP displays better bone healing and regeneration progress than α-CSH after 2 weeks implantation. Therefore, the innovative α-CSH combined with PRP was revealed to be useful in accelerating bone healing and regeneration for the successful defect treatment.

AB - This study aimed to investigate the effect of combining an innovative bioceramic α-calcium sulfate hemihydrate (α-CSH, CaSO4·0.5H2O) bone graft and platelet-rich plasma (PRP) to accelerate bone healing and regeneration in a rabbit model. The bone graft material was implanted bilaterally on rabbit’s artificially maxillary sinus defects: the right maxillary sinus received α-CSH, while α-CSH combine with PRP (α-CSH/PRP) was grafted in left site. The quantity and quality of bone formation after implantation were analyzed radiographically and histologically at 1, 2, and 3 weeks. The micro-computed tomographic results indicated that the bone density of sinus implanted with α-CSH increased and defect volume decreased most after 2 weeks. In histological analysis, both hematoxylin and eosin and Masson trichrome staining of α-CSH/PRP displays better bone healing and regeneration progress than α-CSH after 2 weeks implantation. Therefore, the innovative α-CSH combined with PRP was revealed to be useful in accelerating bone healing and regeneration for the successful defect treatment.

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An innovative bioceramic bone graft with platelet-rich plasma for rapid bone healing and regeneration in a rabbit model

Abstract

Keywords

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