An innovative bioceramic bone graft substitute for bone defect treatment: In vivo evaluation of bone healing

Syamsiah Syam; Yung Chieh Cho; Chung Ming Liu; Mao Suan Huang; Wen Chien Lan; Bai Hung Huang; Takaaki Ueno; Chi Hsun Tsai; Takashi Saito; May Show Chen; Keng Liang Ou

doi:10.3390/app10228303

An innovative bioceramic bone graft substitute for bone defect treatment: In vivo evaluation of bone healing

Syamsiah Syam, Yung Chieh Cho, Chung Ming Liu, Mao Suan Huang, Wen Chien Lan, Bai Hung Huang, Takaaki Ueno, Chi Hsun Tsai, Takashi Saito, May Show Chen, Keng Liang Ou

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

This study aimed to analyze characteristics of an innovative α-calcium sulfate hemihydrate (α-CSH) bioceramic and bone healing and regeneration characteristics following its implantation on artificially created defects of rat models and human jaw defects. The α-CSH bioceramic was characterized using field emission scanning electron microscope (FE-SEM), energy-dispersive spectroscopy (EDS), and thermal-imaging instruments. The material was implanted on artificially created defects in a rat’s right hind leg bone and observed histologically after three days and seven weeks. The material was also implanted in patients with bone defects in the posterior maxillary, then observed immediately and six months post-treatment by panoramic and computed tomography image. The FE-SEM confirm this material is a uniform-shaped short column crystal, while the EDS measurement reveals calcium as the most component in this material. Thermal observation shows temperature change during the setting time is less than 2^◦C, and the maximum temperature reached is 31^◦C. In the histological analysis, α-CSH bioceramic shows new trabecular bone formation and absorbed material at seven weeks post-treatment. Moreover, panoramic and computed tomography image shows intact bone six months post-treatment. Therefore, this study suggests that the innovative α-CSH bioceramic can be useful in bone defect treatment.

Original language	English
Article number	8303
Pages (from-to)	1-13
Number of pages	13
Journal	Applied Sciences (Switzerland)
Volume	10
Issue number	22
DOIs	https://doi.org/10.3390/app10228303
Publication status	Published - Nov 2 2020

Keywords

Bioceramic
Bone defect treatment
Bone graft
Bone healing
Bone regeneration
α-calcium sulfate hemihydrate

ASJC Scopus subject areas

General Materials Science
Instrumentation
General Engineering
Process Chemistry and Technology
Computer Science Applications
Fluid Flow and Transfer Processes

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10.3390/app10228303

Cite this

@article{c36008f82dd44cdfb110a53b2ec47752,

title = "An innovative bioceramic bone graft substitute for bone defect treatment: In vivo evaluation of bone healing",

abstract = "This study aimed to analyze characteristics of an innovative α-calcium sulfate hemihydrate (α-CSH) bioceramic and bone healing and regeneration characteristics following its implantation on artificially created defects of rat models and human jaw defects. The α-CSH bioceramic was characterized using field emission scanning electron microscope (FE-SEM), energy-dispersive spectroscopy (EDS), and thermal-imaging instruments. The material was implanted on artificially created defects in a rat{\textquoteright}s right hind leg bone and observed histologically after three days and seven weeks. The material was also implanted in patients with bone defects in the posterior maxillary, then observed immediately and six months post-treatment by panoramic and computed tomography image. The FE-SEM confirm this material is a uniform-shaped short column crystal, while the EDS measurement reveals calcium as the most component in this material. Thermal observation shows temperature change during the setting time is less than 2◦C, and the maximum temperature reached is 31◦C. In the histological analysis, α-CSH bioceramic shows new trabecular bone formation and absorbed material at seven weeks post-treatment. Moreover, panoramic and computed tomography image shows intact bone six months post-treatment. Therefore, this study suggests that the innovative α-CSH bioceramic can be useful in bone defect treatment.",

keywords = "Bioceramic, Bone defect treatment, Bone graft, Bone healing, Bone regeneration, α-calcium sulfate hemihydrate",

author = "Syamsiah Syam and Cho, {Yung Chieh} and Liu, {Chung Ming} and Huang, {Mao Suan} and Lan, {Wen Chien} and Huang, {Bai Hung} and Takaaki Ueno and Tsai, {Chi Hsun} and Takashi Saito and Chen, {May Show} and Ou, {Keng Liang}",

note = "Funding Information: Funding: The authors would like to thank the Ministry of Science and Technology, Taiwan for financially supporting this research under contract No. MOST 109-2622-8-039-003-TB1. Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

year = "2020",

month = nov,

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doi = "10.3390/app10228303",

language = "English",

volume = "10",

pages = "1--13",

journal = "Applied Sciences (Switzerland)",

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T1 - An innovative bioceramic bone graft substitute for bone defect treatment

T2 - In vivo evaluation of bone healing

AU - Syam, Syamsiah

AU - Cho, Yung Chieh

AU - Liu, Chung Ming

AU - Huang, Mao Suan

AU - Lan, Wen Chien

AU - Huang, Bai Hung

AU - Ueno, Takaaki

AU - Tsai, Chi Hsun

AU - Saito, Takashi

AU - Chen, May Show

AU - Ou, Keng Liang

N1 - Funding Information: Funding: The authors would like to thank the Ministry of Science and Technology, Taiwan for financially supporting this research under contract No. MOST 109-2622-8-039-003-TB1. Publisher Copyright: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020/11/2

Y1 - 2020/11/2

N2 - This study aimed to analyze characteristics of an innovative α-calcium sulfate hemihydrate (α-CSH) bioceramic and bone healing and regeneration characteristics following its implantation on artificially created defects of rat models and human jaw defects. The α-CSH bioceramic was characterized using field emission scanning electron microscope (FE-SEM), energy-dispersive spectroscopy (EDS), and thermal-imaging instruments. The material was implanted on artificially created defects in a rat’s right hind leg bone and observed histologically after three days and seven weeks. The material was also implanted in patients with bone defects in the posterior maxillary, then observed immediately and six months post-treatment by panoramic and computed tomography image. The FE-SEM confirm this material is a uniform-shaped short column crystal, while the EDS measurement reveals calcium as the most component in this material. Thermal observation shows temperature change during the setting time is less than 2◦C, and the maximum temperature reached is 31◦C. In the histological analysis, α-CSH bioceramic shows new trabecular bone formation and absorbed material at seven weeks post-treatment. Moreover, panoramic and computed tomography image shows intact bone six months post-treatment. Therefore, this study suggests that the innovative α-CSH bioceramic can be useful in bone defect treatment.

AB - This study aimed to analyze characteristics of an innovative α-calcium sulfate hemihydrate (α-CSH) bioceramic and bone healing and regeneration characteristics following its implantation on artificially created defects of rat models and human jaw defects. The α-CSH bioceramic was characterized using field emission scanning electron microscope (FE-SEM), energy-dispersive spectroscopy (EDS), and thermal-imaging instruments. The material was implanted on artificially created defects in a rat’s right hind leg bone and observed histologically after three days and seven weeks. The material was also implanted in patients with bone defects in the posterior maxillary, then observed immediately and six months post-treatment by panoramic and computed tomography image. The FE-SEM confirm this material is a uniform-shaped short column crystal, while the EDS measurement reveals calcium as the most component in this material. Thermal observation shows temperature change during the setting time is less than 2◦C, and the maximum temperature reached is 31◦C. In the histological analysis, α-CSH bioceramic shows new trabecular bone formation and absorbed material at seven weeks post-treatment. Moreover, panoramic and computed tomography image shows intact bone six months post-treatment. Therefore, this study suggests that the innovative α-CSH bioceramic can be useful in bone defect treatment.

KW - Bioceramic

KW - Bone defect treatment

KW - Bone graft

KW - Bone healing

KW - Bone regeneration

KW - α-calcium sulfate hemihydrate

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SN - 2076-3417

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SP - 1

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JO - Applied Sciences (Switzerland)

JF - Applied Sciences (Switzerland)

IS - 22

M1 - 8303

ER -

An innovative bioceramic bone graft substitute for bone defect treatment: In vivo evaluation of bone healing

Abstract

Keywords

ASJC Scopus subject areas

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