An innovative bioactive surface with potential hemocompatibility performance for enhancing osseointegration at early-stage implantation

Chien Lin Chen, Wei Chiang Hung, Chung Chih Tseng, Yung Kang Shen, Yung Chieh Cho, Wen Chien Lan, Bai Hung Huang, Jonathan Huang, Chia Chien Hsieh, Fa Chih Shen, Keng Liang Ou

Research output: Contribution to journalArticlepeer-review

Abstract

In the present study, the effectiveness of biomedical titanium (Ti) with plasma oxidation, polymerization, and albumin immobilization in producing a bioactive surface (Ti/rutile TiO2/NH2/protein) that promote hemocompatibility performance was investigated through scanning electron microscopy Raman spectrometry, X-ray photoemission spectroscopy, transmission electron microscopy, wettability examination, and blood clotting time assay. The results indicated that the bioactive surface with uniform island-like immobilized protein clusters was formed on the plasma-oxidized at 240 W specimen. This bioactive surface showed the significantly lowest contact angle as compared with the control (**p < 0.01) and other bioactive surfaces (plasma-oxidized at 80 W and 160 W) (*p < 0.05). In addition, the blood clotting time assay also demonstrated that the bioactive surface with 240 W exhibited the best red blood cell aggregation and adhesion performance. Thus, the fabricated bioactive surface not only increases wettability but also promotes hemocompatibility, thereby could potentially enhancing tissue healing at early-stage post-implantation.

Original languageEnglish
Pages (from-to)33748-33754
Number of pages7
JournalCeramics International
Volume49
Issue number21
DOIs
Publication statusPublished - Nov 1 2023

Keywords

  • Bioactive surface
  • Dental implant
  • Hemocompatibility
  • Plasma modification
  • Wettability

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Process Chemistry and Technology
  • Surfaces, Coatings and Films
  • Materials Chemistry

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