An experimental model for ovarian cancer: propagation of ovarian cancer initiating cells and generation of ovarian cancer organoids

Yu-An Chen, Chen-Yu Lu, Wen-Fang Cheng, Kuan-Ting Kuo, Chen-Wei Yu, Hon-Nerng Ho, Hsin-Fu Chen, Szu-Hua Pan

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Ovarian cancer (OC) is the most lethal gynecological cancer due to the recurrence of drug-resistance. Cancer initiating cells (CICs) are proposed to be responsible for the aggressiveness of OC. The rarity and difficulty of in vitro long-term cultivation of CICs challenge the development of CIC-targeting therapeutics. Reprogramming cancer cells into induced cancer initiating cell (iCICs) could be an approach to solve these. Several inducible CICs have been acquired by activating the expression of stemness genes in different cancer cells. However, few reports have demonstrated the feasibility in OC.
Original languageChinese (Traditional)
JournalBMC Cancer
Volume22
Issue number1
DOIs
Publication statusPublished - 2022
Externally publishedYes

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