An evaluation of the healthcare costs associated with adverse events in patients with breast cancer

Lin Chien Wang, Hsuan Ming Chen, Jin Hua Chen, Yi Chun Lin, Yu Ko

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Objective: Despite the increasing prevalence and costs of breast cancer (BC), little is known about its adverse event (AE)-related costs in Asia. This study aimed to estimate the healthcare expenditures of AEs in patients with BC in Taiwan. Methods: This is a retrospective claims database analysis. The medical costs associated with BC AEs during the first-line treatment period were estimated by use of both a matching method and the generalized linear model (GLM). Results: A total of 50,010 patients diagnosed with breast cancer were identified. Using the case-control matching method, pneumonitis/pneumonia was the AE associated with the greatest total healthcare costs (NT$ 66,889), followed by arthralgia (NT$55,380). In the GLM, the estimated costs ranged from NT$ 1,045 for fatigue to NT$ 116,652 for left heart failure. Moreover, the estimated total healthcare incremental cost increased with the number of AEs (NT$18,157 for 1 AE, NT$33,827 for 2 AEs, NT$39,052 for 3 AEs, NT$53,348 for 4 AEs, and NT$54,215 for 5 AEs and above). Conclusions: The findings indicate that AEs among patients with BC were associated with a substantial economic burden, and healthcare expenditure rose significantly as the number of AEs increased.

Original languageEnglish
Pages (from-to)1465-1475
Number of pages11
JournalInternational Journal of Health Planning and Management
Issue number5
Publication statusPublished - Sept 2021


  • adverse events
  • breast cancer
  • economic burden
  • Taiwan

ASJC Scopus subject areas

  • Health Policy


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