An environmental friendly tapioca starch-alginate cultured scaffold as biomimetic muscle tissue

Che Wei Lin, Po Ting Wu, Kuan Ting Liu, Yu Jui Fan, Jiashing Yu

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Natural porous scaffolds have been studied and developed for decades in biomedical science in order to support cells with a simulated extracellular matrix in natural tissue as an ideal environment. Such three-dimensional scaffolds provide many degrees of freedom to modulate cell activity, such as porosity, pore size, mechanical strength, biodegradability, and biocompatibility. In this study, a porous, three-dimensional material of alginate incorporating tapioca starch was fabricated. A particular freeze-gelation method was applied to homogenously mix starch in the alginate, and the concentration was controllable. This pure natural composite porous scaffold was characterized physically and biologically. The synergistic functions, including biocompatibility, biodegradability, cell adhesion, and cell proliferation, were also investigated. A myogenic differentiation model further verified that the composite porous scaffold provided a suitable environment, supporting the differentiation effect in the myogenic process. The positive results demonstrated that this novel material has the potential to serve as a biomedical or clean meat appliance.

Original languageEnglish
Article number2882
Issue number17
Publication statusPublished - Sept 1 2021


  • Alginate
  • Composite scaffold
  • Myogenic differentiation
  • Starch

ASJC Scopus subject areas

  • General Chemistry
  • Polymers and Plastics


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