The purpose of this review is to update and discuss key findings from in vitro and in vivo studies on apple and its biocompounds, with a special focus on its anticancer role. Several studies have proposed that apple and its extracts exhibit a variety of biological functions that may contribute to health benefits including beneficial effects against chronic heart and vascular disorders, respiratory and pulmonary dysfunction, diabetes, obesity, and cancer. In this review, we summarize the molecular mechanism(s) of various components in apple, as established in previous studies that indicated their growth-inhibitory effects in various cancer cell types. Moreover, an attempt is made to delineate the direction of future studies that could lead to the development of apple components as a potent chemopreventive/chemotherapeutic agent against cancer.

Original languageEnglish
Pages (from-to)119-124
Number of pages6
JournalJournal of Food and Drug Analysis
Issue number1
Publication statusPublished - Jan 1 2017


  • apple
  • cancer chemoprevention
  • phloretin
  • type 2 glucose transporter

ASJC Scopus subject areas

  • Food Science
  • Pharmacology


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