Amplified mycobacterium tuberculosis direct test for diagnosing tuberculous pleurisy-a diagnostic accuracy study

Chieh Mo Lin; Shu Min Lin; Fu Tsai Chung; Horng Chyuan Lin; Kang Yun Lee; Chien Da Huang; Chih Hsi Kuo; Chien Ying Liu; Chun Hua Wang; Han Pin Kuo

doi:10.1371/journal.pone.0044842

Amplified mycobacterium tuberculosis direct test for diagnosing tuberculous pleurisy-a diagnostic accuracy study

Chieh Mo Lin, Shu Min Lin, Fu Tsai Chung, Horng Chyuan Lin, Kang Yun Lee, Chien Da Huang, Chih Hsi Kuo, Chien Ying Liu, Chun Hua Wang, Han Pin Kuo

Research output: Contribution to journal › Article › peer-review

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Abstract

Background: The study was designed to investigate the clinical usefulness of Amplified Mycobacterium Tuberculosis Direct (AMTD) tests for diagnosing TB pleurisy.

Methods: One hundred and fifty-two patients for whom the exclusion of tuberculous pleural effusion was necessary were retrospectively analyzed.

Results: The sensitivity of AMTD in diagnosing pleural TB was 36.4% (20 of 55). Combining sputum and pleural effusion AFB smear, pleural biopsy, and AMTD test of pleural effusion increased sensitivity to 82.5% (33/40). There were significantly higher percentages of neutrophils in the pleural effusion in the positive than in the negative AMTD group (38.0 ± 6.7% vs. 11.1 ± 3.7%, p18 days (70% vs. 31.4%; OR 5.09; 95% CI 1.54-16.79; p = 0.011).

Conclusions: Combining AMTD tests with conventional diagnostic methods offer good sensitivity for pleural TB diagnosis. Patients in the early course of the disease are better candidates for AMTD tests.

Original language	English
Article number	e44842
Journal	PLoS ONE
Volume	7
Issue number	9
DOIs	https://doi.org/10.1371/journal.pone.0044842
Publication status	Published - Sept 10 2012
Externally published	Yes

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title = "Amplified mycobacterium tuberculosis direct test for diagnosing tuberculous pleurisy-a diagnostic accuracy study",

abstract = "Background: The study was designed to investigate the clinical usefulness of Amplified Mycobacterium Tuberculosis Direct (AMTD) tests for diagnosing TB pleurisy.Methods: One hundred and fifty-two patients for whom the exclusion of tuberculous pleural effusion was necessary were retrospectively analyzed.Results: The sensitivity of AMTD in diagnosing pleural TB was 36.4% (20 of 55). Combining sputum and pleural effusion AFB smear, pleural biopsy, and AMTD test of pleural effusion increased sensitivity to 82.5% (33/40). There were significantly higher percentages of neutrophils in the pleural effusion in the positive than in the negative AMTD group (38.0 ± 6.7% vs. 11.1 ± 3.7%, p18 days (70% vs. 31.4%; OR 5.09; 95% CI 1.54-16.79; p = 0.011).Conclusions: Combining AMTD tests with conventional diagnostic methods offer good sensitivity for pleural TB diagnosis. Patients in the early course of the disease are better candidates for AMTD tests.",

author = "Lin, {Chieh Mo} and Lin, {Shu Min} and Chung, {Fu Tsai} and Lin, {Horng Chyuan} and Lee, {Kang Yun} and Huang, {Chien Da} and Kuo, {Chih Hsi} and Liu, {Chien Ying} and Wang, {Chun Hua} and Kuo, {Han Pin}",

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doi = "10.1371/journal.pone.0044842",

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AU - Lin, Chieh Mo

AU - Lin, Shu Min

AU - Chung, Fu Tsai

AU - Lin, Horng Chyuan

AU - Lee, Kang Yun

AU - Huang, Chien Da

AU - Kuo, Chih Hsi

AU - Liu, Chien Ying

AU - Wang, Chun Hua

AU - Kuo, Han Pin

PY - 2012/9/10

Y1 - 2012/9/10

N2 - Background: The study was designed to investigate the clinical usefulness of Amplified Mycobacterium Tuberculosis Direct (AMTD) tests for diagnosing TB pleurisy.Methods: One hundred and fifty-two patients for whom the exclusion of tuberculous pleural effusion was necessary were retrospectively analyzed.Results: The sensitivity of AMTD in diagnosing pleural TB was 36.4% (20 of 55). Combining sputum and pleural effusion AFB smear, pleural biopsy, and AMTD test of pleural effusion increased sensitivity to 82.5% (33/40). There were significantly higher percentages of neutrophils in the pleural effusion in the positive than in the negative AMTD group (38.0 ± 6.7% vs. 11.1 ± 3.7%, p18 days (70% vs. 31.4%; OR 5.09; 95% CI 1.54-16.79; p = 0.011).Conclusions: Combining AMTD tests with conventional diagnostic methods offer good sensitivity for pleural TB diagnosis. Patients in the early course of the disease are better candidates for AMTD tests.

AB - Background: The study was designed to investigate the clinical usefulness of Amplified Mycobacterium Tuberculosis Direct (AMTD) tests for diagnosing TB pleurisy.Methods: One hundred and fifty-two patients for whom the exclusion of tuberculous pleural effusion was necessary were retrospectively analyzed.Results: The sensitivity of AMTD in diagnosing pleural TB was 36.4% (20 of 55). Combining sputum and pleural effusion AFB smear, pleural biopsy, and AMTD test of pleural effusion increased sensitivity to 82.5% (33/40). There were significantly higher percentages of neutrophils in the pleural effusion in the positive than in the negative AMTD group (38.0 ± 6.7% vs. 11.1 ± 3.7%, p18 days (70% vs. 31.4%; OR 5.09; 95% CI 1.54-16.79; p = 0.011).Conclusions: Combining AMTD tests with conventional diagnostic methods offer good sensitivity for pleural TB diagnosis. Patients in the early course of the disease are better candidates for AMTD tests.

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Amplified mycobacterium tuberculosis direct test for diagnosing tuberculous pleurisy-a diagnostic accuracy study

Abstract

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UN SDGs

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