Altered sensory nerve excitability in fibromyalgia

Hao Wen Teng; Jowy Tani; Tsui San Chang; Hung Ju Chen; Yi Chen Lin; Cindy Shin Yi Lin; Jia Ying Sung

doi:10.1016/j.jfma.2021.02.003

Altered sensory nerve excitability in fibromyalgia

Hao Wen Teng, Jowy Tani, Tsui San Chang, Hung Ju Chen, Yi Chen Lin, Cindy Shin Yi Lin, Jia Ying Sung

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Background/purpose: To investigate nerve excitability changes in patients with fibromyalgia and the correlation with clinical severity. Methods: We enrolled 20 subjects with fibromyalgia and 22 sex and age-matched healthy subjects to receive nerve excitability test and nerve conduction study to evaluate the peripheral axonal function. Results: In the fibromyalgia cohort, the sensory axonal excitability test revealed increased superexcitability (%) (P = 0.029) compared to healthy control. Correlational study showed a negative correlation between increased subexcitability (%) (r = −0.534, P = 0.022) with fibromyalgia impact questionnaire (FIQ) score. Computer modeling confirmed that the sensory axon excitability pattern we observed in fibromyalgia cohort was best explained by increased Barrett–Barrett conductance, which was thought to be attributed to paranodal fast K⁺ channel dysfunction. Conclusion: The present study revealed that paranodal sensory K⁺ conductance was altered in patients with fibromyalgia. The altered conductance indicated dysfunction of paranodal fast K⁺ channels, which is known to be associated with the generation of pain.

Original language	English
Pages (from-to)	1611-1619
Number of pages	9
Journal	Journal of the Formosan Medical Association
Volume	120
Issue number	8
DOIs	https://doi.org/10.1016/j.jfma.2021.02.003
Publication status	Published - Aug 2021

Keywords

Fibromyalgia
Nerve excitability
Pain
Potassium channel
Superexcitability

ASJC Scopus subject areas

General Medicine

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10.1016/j.jfma.2021.02.003

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@article{8f776cf89645448e9221eca70192d879,

title = "Altered sensory nerve excitability in fibromyalgia",

abstract = "Background/purpose: To investigate nerve excitability changes in patients with fibromyalgia and the correlation with clinical severity. Methods: We enrolled 20 subjects with fibromyalgia and 22 sex and age-matched healthy subjects to receive nerve excitability test and nerve conduction study to evaluate the peripheral axonal function. Results: In the fibromyalgia cohort, the sensory axonal excitability test revealed increased superexcitability (%) (P = 0.029) compared to healthy control. Correlational study showed a negative correlation between increased subexcitability (%) (r = −0.534, P = 0.022) with fibromyalgia impact questionnaire (FIQ) score. Computer modeling confirmed that the sensory axon excitability pattern we observed in fibromyalgia cohort was best explained by increased Barrett–Barrett conductance, which was thought to be attributed to paranodal fast K+ channel dysfunction. Conclusion: The present study revealed that paranodal sensory K+ conductance was altered in patients with fibromyalgia. The altered conductance indicated dysfunction of paranodal fast K+ channels, which is known to be associated with the generation of pain.",

keywords = "Fibromyalgia, Nerve excitability, Pain, Potassium channel, Superexcitability",

author = "Teng, {Hao Wen} and Jowy Tani and Chang, {Tsui San} and Chen, {Hung Ju} and Lin, {Yi Chen} and Lin, {Cindy Shin Yi} and Sung, {Jia Ying}",

note = "Funding Information: C. S.-Y. Lin was supported by grants from Sydney Medical School Foundation , Faculty of Medicine Health, Sydney University, Sydney, Australia. H.-W. Teng was supported by grant from Wan Fang Hospital, Taipei Medical University ( 105-wf-eva-03 ), J. Tani was supported by grant from Wan Fang Hospital, Taipei Medical University ( 110-phd-02 ), Y.-C. Lin was supported by grant from Wan Fang Hospital, Taipei Medical University ( 109-wf-eva-22 ), and J.-Y. Sung was supported by grants from the Ministry of Science and Technology, Taiwan , ROC ( 104-2314-B-038-012-MY3 ) and Wan Fang Hospital, Taipei Medical University ( 109-swf-eva-06 ). Publisher Copyright: {\textcopyright} 2021 Formosan Medical Association",

year = "2021",

month = aug,

doi = "10.1016/j.jfma.2021.02.003",

language = "English",

volume = "120",

pages = "1611--1619",

journal = "Journal of the Formosan Medical Association",

issn = "0929-6646",

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TY - JOUR

T1 - Altered sensory nerve excitability in fibromyalgia

AU - Teng, Hao Wen

AU - Tani, Jowy

AU - Chang, Tsui San

AU - Chen, Hung Ju

AU - Lin, Yi Chen

AU - Lin, Cindy Shin Yi

AU - Sung, Jia Ying

N1 - Funding Information: C. S.-Y. Lin was supported by grants from Sydney Medical School Foundation , Faculty of Medicine Health, Sydney University, Sydney, Australia. H.-W. Teng was supported by grant from Wan Fang Hospital, Taipei Medical University ( 105-wf-eva-03 ), J. Tani was supported by grant from Wan Fang Hospital, Taipei Medical University ( 110-phd-02 ), Y.-C. Lin was supported by grant from Wan Fang Hospital, Taipei Medical University ( 109-wf-eva-22 ), and J.-Y. Sung was supported by grants from the Ministry of Science and Technology, Taiwan , ROC ( 104-2314-B-038-012-MY3 ) and Wan Fang Hospital, Taipei Medical University ( 109-swf-eva-06 ). Publisher Copyright: © 2021 Formosan Medical Association

PY - 2021/8

Y1 - 2021/8

N2 - Background/purpose: To investigate nerve excitability changes in patients with fibromyalgia and the correlation with clinical severity. Methods: We enrolled 20 subjects with fibromyalgia and 22 sex and age-matched healthy subjects to receive nerve excitability test and nerve conduction study to evaluate the peripheral axonal function. Results: In the fibromyalgia cohort, the sensory axonal excitability test revealed increased superexcitability (%) (P = 0.029) compared to healthy control. Correlational study showed a negative correlation between increased subexcitability (%) (r = −0.534, P = 0.022) with fibromyalgia impact questionnaire (FIQ) score. Computer modeling confirmed that the sensory axon excitability pattern we observed in fibromyalgia cohort was best explained by increased Barrett–Barrett conductance, which was thought to be attributed to paranodal fast K+ channel dysfunction. Conclusion: The present study revealed that paranodal sensory K+ conductance was altered in patients with fibromyalgia. The altered conductance indicated dysfunction of paranodal fast K+ channels, which is known to be associated with the generation of pain.

AB - Background/purpose: To investigate nerve excitability changes in patients with fibromyalgia and the correlation with clinical severity. Methods: We enrolled 20 subjects with fibromyalgia and 22 sex and age-matched healthy subjects to receive nerve excitability test and nerve conduction study to evaluate the peripheral axonal function. Results: In the fibromyalgia cohort, the sensory axonal excitability test revealed increased superexcitability (%) (P = 0.029) compared to healthy control. Correlational study showed a negative correlation between increased subexcitability (%) (r = −0.534, P = 0.022) with fibromyalgia impact questionnaire (FIQ) score. Computer modeling confirmed that the sensory axon excitability pattern we observed in fibromyalgia cohort was best explained by increased Barrett–Barrett conductance, which was thought to be attributed to paranodal fast K+ channel dysfunction. Conclusion: The present study revealed that paranodal sensory K+ conductance was altered in patients with fibromyalgia. The altered conductance indicated dysfunction of paranodal fast K+ channels, which is known to be associated with the generation of pain.

KW - Fibromyalgia

KW - Nerve excitability

KW - Pain

KW - Potassium channel

KW - Superexcitability

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DO - 10.1016/j.jfma.2021.02.003

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JO - Journal of the Formosan Medical Association

JF - Journal of the Formosan Medical Association

IS - 8

ER -

Altered sensory nerve excitability in fibromyalgia

Abstract

Keywords

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