Abstract
| Original language | English |
|---|---|
| Journal | PLoS One |
| Volume | 9 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2014 |
| Externally published | Yes |
Keywords
- adult
- anterior cingulate
- article
- bipolar disorder
- brain region
- clinical article
- cognition
- controlled study
- corpus striatum
- default mode network
- female
- frontal cortex
- functional anatomy
- hippocampus
- human
- male
- neuromodulation
- neuropathology
- posterior cingulate
- thalamus
- algorithm
- biological model
- cingulate gyrus
- connectome
- image processing
- middle aged
- nerve cell network
- nerve tract
- nuclear magnetic resonance imaging
- pathophysiology
- procedures
- radiography
- rest
- Adult
- Algorithms
- Bipolar Disorder
- Connectome
- Corpus Striatum
- Female
- Gyrus Cinguli
- Humans
- Image Processing, Computer-Assisted
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Models, Neurological
- Nerve Net
- Neural Pathways
- Rest
- Thalamus
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In: PLoS One, Vol. 9, No. 5, 2014.
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}
TY - JOUR
T1 - Altered resting-state functional connectivity of striatal-thalamic circuit in bipolar disorder
AU - Teng, Shin
AU - Lu, Chia-Feng
AU - Wang, Po-Shan
AU - Li, Cheng-Ta
AU - Tu, Pei-Chi
AU - Hung, Chih I.
AU - Su, Tung-Ping
AU - Wu, Yu-Te
N1 - 被引用次數：1 Export Date: 31 March 2016 CODEN: POLNC 參考文獻: Merikangas, K.R., Akiskal, H.S., Angst, J., Greenberg, P.E., Hirschfeld, R.M.A., Petukhova, M., Kessler, R.C., Lifetime and 12-month prevalence of bipolar spectrum disorder in the national comorbidity survey replication (2007) Archives of General Psychiatry, 64 (5), pp. 543-552. , http://archpsyc.ama-assn.org/cgi/reprint/64/5/543.pdf, DOI 10.1001/archpsyc.64.5.543; Murray, C.J.L., Lopez, A.D., Global mortality, disability, and the contribution of risk factors: Global burden of disease study (1997) Lancet, 349 (9063), pp. 1436-1442. , DOI 10.1016/S0140-6736(96)07495-8; Bora, E., Yucel, M., Pantelis, C., Cognitive endophenotypes of bipolar disorder: A meta-analysis of neuropsychological deficits in euthymic patients and their first-degree relatives (2009) Journal of Affective Disorders, 113, pp. 1-20; Minassian, A., Paulus, M.P., Perry, W., Increased sensitivity to error during decision-making in bipolar disorder patients with acute mania (2004) Journal of Affective Disorders, 82 (2), pp. 203-208. , DOI 10.1016/j.jad.2003.11.010, PII S0165032703003148; 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PY - 2014
Y1 - 2014
N2 - Bipolar disorder is characterized by internally affective fluctuations. The abnormality of inherently mental state can be assessed using resting-state fMRI data without producing task-induced biases. In this study, we hypothesized that the resting-state connectivity related to the frontal, striatal, and thalamic regions, which were associated with mood regulations and cognitive functions, can be altered for bipolar disorder. We used the Pearson's correlation coefficients to estimate functional connectivity followed by the hierarchical modular analysis to categorize the resting-state functional regions of interest (ROIs). The selected functional connectivities associated with the striatal-thalamic circuit and default mode network (DMN) were compared between bipolar patients and healthy controls. Significantly decreased connectivity in the striatalthalamic circuit and between the striatal regions and the middle and posterior cingulate cortex was observed in the bipolar patients. We also observed that the bipolar patients exhibited significantly increased connectivity between the thalamic regions and the parahippocampus. No significant changes of connectivity related to the frontal regions in the DMN were observed. The changed resting-state connectivity related to the striatal-thalamic circuit might be an inherent basis for the altered emotional and cognitive processing in the bipolar patients. © 2014 Teng et al.
AB - Bipolar disorder is characterized by internally affective fluctuations. The abnormality of inherently mental state can be assessed using resting-state fMRI data without producing task-induced biases. In this study, we hypothesized that the resting-state connectivity related to the frontal, striatal, and thalamic regions, which were associated with mood regulations and cognitive functions, can be altered for bipolar disorder. We used the Pearson's correlation coefficients to estimate functional connectivity followed by the hierarchical modular analysis to categorize the resting-state functional regions of interest (ROIs). The selected functional connectivities associated with the striatal-thalamic circuit and default mode network (DMN) were compared between bipolar patients and healthy controls. Significantly decreased connectivity in the striatalthalamic circuit and between the striatal regions and the middle and posterior cingulate cortex was observed in the bipolar patients. We also observed that the bipolar patients exhibited significantly increased connectivity between the thalamic regions and the parahippocampus. No significant changes of connectivity related to the frontal regions in the DMN were observed. The changed resting-state connectivity related to the striatal-thalamic circuit might be an inherent basis for the altered emotional and cognitive processing in the bipolar patients. © 2014 Teng et al.
KW - adult
KW - anterior cingulate
KW - article
KW - bipolar disorder
KW - brain region
KW - clinical article
KW - cognition
KW - controlled study
KW - corpus striatum
KW - default mode network
KW - female
KW - frontal cortex
KW - functional anatomy
KW - hippocampus
KW - human
KW - male
KW - neuromodulation
KW - neuropathology
KW - posterior cingulate
KW - thalamus
KW - algorithm
KW - biological model
KW - cingulate gyrus
KW - connectome
KW - image processing
KW - middle aged
KW - nerve cell network
KW - nerve tract
KW - nuclear magnetic resonance imaging
KW - pathophysiology
KW - procedures
KW - radiography
KW - rest
KW - Adult
KW - Algorithms
KW - Bipolar Disorder
KW - Connectome
KW - Corpus Striatum
KW - Female
KW - Gyrus Cinguli
KW - Humans
KW - Image Processing, Computer-Assisted
KW - Magnetic Resonance Imaging
KW - Male
KW - Middle Aged
KW - Models, Neurological
KW - Nerve Net
KW - Neural Pathways
KW - Rest
KW - Thalamus
UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-84900424920&partnerID=40&md5=8be16efd1d85c8a3c13f8e8d89fcca62
UR - https://www.scopus.com/results/citedbyresults.uri?sort=plf-f&cite=2-s2.0-84900424920&src=s&imp=t&sid=7698cc64b5f67d098141a9c312be4dd1&sot=cite&sdt=a&sl=0&origin=recordpage&editSaveSearch=&txGid=9961d332dc0e23b4fbbca32339e65883
U2 - 10.1371/journal.pone.0096422
DO - 10.1371/journal.pone.0096422
M3 - Article
SN - 1932-6203
VL - 9
JO - PLoS One
JF - PLoS One
IS - 5
ER -