Altered negative BOLD responses in the default-mode network during emotion processing in depressed subjects

Simone Grimm, Peter Boesiger, Johannes Beck, Daniel Schuepbach, Felix Bermpohl, Martin Walter, Jutta Ernst, Daniel Hell, Heinz Boeker, Georg Northoff

Research output: Contribution to journalArticlepeer-review

242 Citations (Scopus)


Studies using functional magnetic resonance imaging (fMRI) show predominant negative blood oxygenation level-dependent (BOLD) responses (NBRs) in regions of the default-mode network such as the pregenual anterior cingulate cortex, the ventromedial prefrontal cortex, and the posterior cingulate cortex. Patients with major depressive disorder (MDD) show emotional-cognitive disturbances, which have been associated with alterations within the default-mode network. However, it remains unclear whether these default-mode network alterations are related to abnormalities in NBRs. We therefore investigated neural activity in the default-mode network during different emotional tasks in patients with MDD in an event-related fMRI design. MDD patients showed significantly reduced NBRs in several regions of the default-mode network. Decreased NBRs in MDD patients correlated with depression severity and feelings of hopelessness. In sum, our findings demonstrate that default-mode network NBRs are reduced in MDD and modulate these patients' abnormally negative emotions.

Original languageEnglish
Pages (from-to)932-943
Number of pages12
Issue number4
Publication statusPublished - Mar 2009


  • Default-mode network
  • Emotional processing
  • Event-related fMRI
  • Major depressive disorder
  • Negative BOLD responses

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health


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