Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 1072-1082 |
| Number of pages | 11 |
| Journal | Schizophrenia Bulletin |
| Volume | 40 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2014 |
| Externally published | Yes |
Keywords
- Connectivity
- Functional magnetic resonance imaging
- Posterior cingulate cortex
- Posterior insula
- Psychosis
- Ventral premotor cortex
- adult
- anterior insula
- article
- BOLD signal
- brain region
- clinical article
- consensus
- controlled study
- female
- functional magnetic resonance imaging
- functional neuroimaging
- human
- insula
- left hemisphere
- male
- personal experience
- postcentral gyrus
- posterior cingulate
- posterior insula
- posterior parietal cortex
- premotor cortex
- priority journal
- right hemisphere
- schizophrenia
- self experience
- social cognition
- social interaction
- somatosensory cortex
- brain cortex
- cingulate gyrus
- connectome
- ego
- motor cortex
- nuclear magnetic resonance imaging
- pathophysiology
- perception
- Adult
- Cerebral Cortex
- Connectome
- Ego
- Female
- Gyrus Cinguli
- Humans
- Magnetic Resonance Imaging
- Male
- Motor Cortex
- Schizophrenia
- Social Perception
Fingerprint
Dive into the research topics of 'Altered brain long-range functional interactions underlying the link between aberrant self-experience and self-other relationship in first-episode schizophrenia'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS
In: Schizophrenia Bulletin, Vol. 40, No. 5, 2014, p. 1072-1082.
Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Altered brain long-range functional interactions underlying the link between aberrant self-experience and self-other relationship in first-episode schizophrenia
AU - Ebisch, Sjoerd J H
AU - Mantini, Dante
AU - Northoff, G.
AU - Salone, Anatolia
AU - De Berardis, Domenico
AU - Ferri, Filippo Maria Aria
AU - Ferro, Filippo Maria Aria
AU - Di Giannantonio, Massimo
AU - Romani, Gian Luca Uca
AU - Gallese, Gian Luca Uca
N1 - Cited By :12 Export Date: 11 May 2016 CODEN: SCZBB Correspondence Address: Ebisch, S.J.H.; Department of Neuroscience and Imaging, G. d'Annunzio University, Via dei Vestini, 33, 66013 Chieti, Italy; email: [email protected] Funding Details: 320030-146531, SNSF, Swiss National Science Foundation References: Bleuler, E., Dementia praecox oder gruppe der schizophrenien (1911) Handbuch der Psychiatrie, , In: Aschaffenburg G, ed. Leipzig, Germany: Deuticke; Minkowski, E., (1927) La Schizophrénie. Psychopathologie des Schizoïdes et des Schizophrènes, , Paris, France: Payot; Parnas, J., Bovet, P., Zahavi, D., Schizophrenic autism: Clinical phenomenology and pathogenetic implications (2002) World Psychiatry., 1, pp. 131-136; Parnas, J., Møller, P., Kircher, T., Ease: Examination of anomalous self-experience (2005) Psychopathology., 38, pp. 236-258; Gallese, V., The roots of empathy: The shared manifold hypothesis and the neural basis of intersubjectivity (2003) Psychopathology., 36, pp. 171-180; Sass, L.A., Parnas, J., Schizophrenia, consciousness, and the self (2003) Schizophr Bull., 29, pp. 427-444; Sass, L.A., Self-disturbance and schizophrenia: Structure, specificity, pathogenesis (current issues, new directions). [published online ahead of print june 14, 2013] (2013) Schizophr Res., , pii: S0920-9964(13) 00272-7. doi: 10.1016/j.schres.2013.05.017; Nelson, B., Fornito, A., Harrison, B.J., A disturbed sense of self in the psychosis prodrome: Linking phenomenology and neurobiology (2009) Neurosci Biobehav Rev., 33, pp. 807-817; Huber, G., Gross, G., The concept of basic symptoms in schizophrenic and schizoaffective psychoses (1989) Recenti Prog Med., 80, pp. 646-652; Klosterkötter, J., The meaning of basic symptoms for the genesis of the schizophrenic nuclear syndrome (1992) Jpn J Psychiatry Neurol., 46, pp. 609-630; Ihnen, G.H., Penn, D.L., Corrigan, P.W., Martin, J., Social perception and social skill in schizophrenia (1998) Psychiatry Res., 80, pp. 275-286; Bentall, R.P., Baker, G.A., Havers, S., Reality monitoring and psychotic hallucinations (1991) Br J Clin Psychol., 30 (PART 3), pp. 213-222; Georgieff, N., Jeannerod, M., Beyond consciousness of external reality: A "who" system for consciousness of action and selfconsciousness (1998) Conscious Cogn., 7, pp. 465-477; Blakemore, S.J., Smith, J., Steel, R., Johnstone, C.E., Frith, C.D., The perception of self-produced sensory stimuli in patients with auditory hallucinations and passivity experiences: Evidence for a breakdown in self-monitoring (2000) Psychol Med., 30, pp. 1131-1139; Franck, N., Farrer, C., Georgieff, N., Defective recognition of one's own actions in patients with schizophrenia (2001) Am J Psychiatry., 158, pp. 454-459; Vinogradov, S., Luks, T.L., Schulman, B.J., Simpson, G.V., Deficit in a neural correlate of reality monitoring in schizophrenia patients (2008) Cereb Cortex., 18, pp. 2532-2539; Voss, M., Moore, J., Hauser, M., Gallinat, J., Heinz, A., Haggard, P., Altered awareness of action in schizophrenia: A specific deficit in predicting action consequences (2010) Brain., 133, pp. 3104-3112; Botvinick, M., Cohen, J., Rubber hands 'feel' touch that eyes see (1998) Nature., 391, p. 756; Peled, A., Ritsner, M., Hirschmann, S., Geva, A.B., Modai, I., Touch feel illusion in schizophrenic patients (2000) Biol Psychiatry., 48, pp. 1105-1108; Morgan, H.L., Turner, D.C., Corlett, P.R., Exploring the impact of ketamine on the experience of illusory body ownership (2011) Biol Psychiatry., 69, pp. 35-41; Ebisch, S.J., Salone, A., Ferri, F., Out of touch with reality? Social perception in first-episode schizophrenia (2013) Soc Cogn Affect Neurosci., 8, pp. 394-403; Volkow, N.D., Wolf, A.P., Brodie, J.D., Brain interactions in chronic schizophrenics under resting and activation conditions (1988) Schizophr Res., 1, pp. 47-53; Friston, K.J., Frith, C.D., Schizophrenia: A disconnection syndrome? (1995) Clin Neurosci., 3, pp. 89-97; Bullmore, E.T., Frangou, S., Murray, R.M., The dysplastic net hypo thesis: An integration of developmental and dysconnectivity theories of schizophrenia (1997) Schizophr Res., 28, pp. 143-156; Meyer-Lindenberg, A., Weinberger, D.R., Intermediate phenotypes and genetic mechanisms of psychiatric disorders (2006) Nat Rev Neurosci., 7, pp. 818-827; Fornito, A., Zalesky, A., Pantelis, C., Bullmore, E.T., Schizophrenia, neuroimaging and connectomics (2012) Neuroimage., 62, pp. 2296-2314; Pettersson-Yeo, W., Allen, P., Benetti, S., McGuire, P., Mechelli, A., Dysconnectivity in schizophrenia: Where are we now? (2011) Neurosci Biobehav Rev., 35, pp. 1110-1124; Uhlhaas, P.J., Singer, W., Abnormal neural oscillations and synchrony in schizophrenia (2010) Nat Rev Neurosci., 11, pp. 100-113; Calhoun, V.D., Eichele, T., Pearlson, G., Functional brain networks in schizophrenia: A review (2009) Front Hum Neurosci., 3, p. 17; Woodward, N.D., Rogers, B., Heckers, S., Functional restingstate networks are differentially affected in schizophrenia (2011) Schizophr Res., 130, pp. 86-93; Walterfang, M., Wood, S.J., Velakoulis, D., Pantelis, C., Neuropathological, neurogenetic and neuroimaging evidence for white matter pathology in schizophrenia (2006) Neurosci Biobehav Rev., 30, pp. 918-948; Skudlarski, P., Jagannathan, K., Anderson, K., Brain connectivity is not only lower but different in schizophrenia: A combined anatomical and functional approach (2010) Biol Psychiatry., 68, pp. 61-69; Lynall, M.E., Bassett, D.S., Kerwin, R., Functional connectivity and brain networks in schizophrenia (2010) J Neurosci., 30, pp. 9477-9487; De Pasquale, F., Sabatini, U., Della Penna, S., The connectivity of functional cores reveals different degrees of segregation and integration in the brain at rest (2013) Neuroimage., 69, pp. 51-61; Hagmann, P., Cammoun, L., Gigandet, X., Mapping the structural core of human cerebral cortex (2008) PLoS Biol., 6, pp. e159; Buckner, R.L., Andrews-Hanna, J.R., Schacter, D.L., The brain's default network: Anatomy, function, and relevance to disease (2008) Ann N Y Acad Sci., 1124, pp. 1-38; Raichle, M.E., MacLeod, A.M., Snyder, A.Z., Powers, W.J., Gusnard, D.A., Shulman, G.L., A default mode of brain function (2001) Proc Natl Acad Sci U S A., 98, pp. 676-682; De Pasquale, F., Della Penna, S., Snyder, A.Z., A cortical core for dynamic integration of functional networks in the resting human brain (2012) Neuron., 74, pp. 753-764; Uddin, L.Q., Kelly, A.M., Biswal, B.B., Castellanos, F.X., Milham, M.P., Functional connectivity of default mode network components: Correlation, anticorrelation, and causality (2009) Hum Brain Mapp., 30, pp. 625-637; Northoff, G., Richter, A., Bermpohl, F., Nmda hypofunction in the posterior cingulate as a model for schizophrenia: An exploratory ketamine administration study in fmri (2005) Schizophr Res., 72, pp. 235-248; Nelson, B., Fornito, A., Harrison, B.J., A disturbed sense of self in the psychosis prodrome: Linking phenomenology and neurobiology (2009) Neurosci Biobehav Rev., 33, pp. 807-817; Qin, P., Northoff, G., How is our self related to midline regions and the default-mode network? (2011) Neuroimage., 57, pp. 1221-1233; Northoff, G., Heinzel, A., De Greck, M., Bermpohl, F., Dobrowolny, H., Panksepp, J., Self-referential processing in our brain-A meta-analysis of imaging studies on the self (2006) Neuroimage., 31, pp. 440-457; Northoff, G., Qin, P., Nakao, T., Rest-stimulus interaction in the brain: A review (2010) Trends Neurosci., 33, pp. 277-284; Johnson, M.K., Raye, C.L., Mitchell, K.J., Touryan, S.R., Greene, E.J., Nolen-Hoeksema, S., Dissociating medial frontal and posterior cingulate activity during self-reflection (2006) Soc Cogn Affect Neurosci., 1, pp. 56-64; Northoff, G., Bermpohl, F., Cortical midline structures and the self (2004) Trends Cogn Sci., 8, pp. 102-107; Leech, R., Braga, R., Sharp, D.J., Echoes of the brain within the posterior cingulate cortex (2012) J Neurosci., 32, pp. 215-222; Wiebking, C., Duncan, N.W., Qin, P., External awareness and gaba-A multimodal imaging study combining fmri and [(18) f]flumazenil-pet. [published online ahead of print september 21, 2012] (2012) Hum Brain Mapp., , doi: 10.1002/ hbm.22166; Northoff, G., Panksepp, J., The trans-species concept of self and the subcortical-cortical midline system (2008) Trends Cogn Sci., 12, pp. 259-264; Van Dijk, K.R., Hedden, T., Venkataraman, A., Evans, K.C., Lazar, S.W., Buckner, R.L., Intrinsic functional connectivity as a tool for human connectomics: Theory, properties, and optimization (2010) J Neurophysiol., 103, pp. 297-321; Fox, M.D., Raichle, M.E., Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging (2007) Nat Rev Neurosci., 8, pp. 700-711; Ebisch, S.J., Mantini, D., Romanelli, R., Long-range functional interactions of anterior insula and medial frontal cortex are differently modulated by visuospatial and inductive reasoning tasks (2013) Neuroimage., 78, pp. 426-438; Norman-Haignere, S.V., McCarthy, G., Chun, M.M., Turk- Browne, N.B., Category-selective background connectivity in ventral visual cortex (2012) Cereb Cortex., 22, pp. 391-402; Kay, S.R., Fiszbein, A., Opler, L.A., The positive and negative syndrome scale (panss) for schizophrenia (1987) Schizophr Bull., 13, pp. 261-276; Klosterkötter, J., Hellmich, M., Steinmeyer, E.M., Schultze- Lutter, F., Diagnosing schizophrenia in the initial prodromal phase (2001) Arch Gen Psychiatry., 58, pp. 158-164; Kay, S.R., Fiszbein, A., Opler, L.A., The positive and negative syndrome scale (panss) for schizophrenia (1987) Schizophr Bull., 13, pp. 261-276; Schultze-Lutter, F., Addington, J., Ruhrmann, S., Klosterkötter, J., (2011) Strumento di Valutazione Per la Propensione Alla Schizofrenia, , Versione per adulti. Trad. Giuliano Aiello. Rome, Italy: Giovanni Fioriti Editore srl; Auer, D.P., Spontaneous low-frequency blood oxygenation level-dependent fluctuations and functional connectivity analysis of the 'resting' brain (2008) Magn Reson Imaging., 26, pp. 1055-1064; Cordes, D., Haughton, V.M., Arfanakis, K., Frequencies contributing to functional connectivity in the cerebral cortex in "resting-state" data (2001) AJNR Am J Neuroradiol., 22, pp. 1326-1333; Fox, M.D., Zhang, D., Snyder, A.Z., Raichle, M.E., The global signal and observed anticorrelated resting state brain networks (2009) J Neurophysiol., 101, pp. 3270-3283; He, B.J., Snyder, A.Z., Vincent, J.L., Epstein, A., Shulman, G.L., Corbetta, M., Breakdown of functional connectivity in frontoparietal networks underlies behavioral deficits in spatial neglect (2007) Neuron., 53, pp. 905-918; Fair, D.A., Schlaggar, B.L., Cohen, A.L., A method for using blocked and event-related fmri data to study "resting state" functional connectivity (2007) Neuroimage., 35, pp. 396-405; Power, J.D., Barnes, K.A., Snyder, A.Z., Schlaggar, B.L., Petersen, S.E., Spurious but systematic correlations in functional connectivity mri networks arise from subject motion (2012) Neuroimage., 59, pp. 2142-2154; Ebisch, S.J., Gallese, V., Willems, R.M., Altered intrinsic functional connectivity of anterior and posterior insula regions in high-functioning participants with autism spectrum disorder (2011) Hum Brain Mapp., 32, pp. 1013-1028; Zar, J.H., (1996) Biostatistical Analysis, , Upper Saddle River, NJ: Prentice-Hall; Genovese, C.R., Lazar, N.A., Nichols, T., Thresholding of statistical maps in functional neuroimaging using the false discovery rate (2002) Neuroimage., 15, pp. 870-878; Mantini, D., Gerits, A., Nelissen, K., Default mode of brain function in monkeys (2011) J Neurosci., 31, pp. 12954-12962; Huang, Z., Dai, R., Wu, X., The self and its resting state in consciousness: An investigation of the vegetative state. [published online ahead of print july 01, 2013] (2013) Hum Brain Mapp., , doi: 10.1002/hbm.22308; Zuo, X.N., Di Martino, A., Kelly, C., The oscillating brain: Complex and reliable (2010) Neuroimage., 49, pp. 1432-1445; Bluhm, R.L., Miller, J., Lanius, R.A., Spontaneous lowfrequency fluctuations in the bold signal in schizophrenic patients: Anomalies in the default network (2007) Schizophr Bull., 33, pp. 1004-1012; Mannell, M.V., Franco, A.R., Calhoun, V.D., Cañive, J.M., Thoma, R.J., Mayer, A.R., Resting state and task-induced deactivation: A methodological comparison in patients with schizophrenia and healthy controls (2010) Hum Brain Mapp., 31, pp. 424-437; Skudlarski, P., Jagannathan, K., Anderson, K., Brain connectivity is not only lower but different in schizophrenia: A combined anatomical and functional approach (2010) Biol Psychiatry., 68, pp. 61-69; Mazza, M., Catalucci, A., Pino, M.C., Dysfunctional neural networks associated with impaired social interactions in early psychosis: An ica analysis. [published online ahead of print march 12, 2013] (2013) Brain Imaging Behav., , doi: 10.1007/ s11682-013-9223-6; Hampson, M., Peterson, B.S., Skudlarski, P., Gatenby, J.C., Gore, J.C., Detection of functional connectivity using temporal correlations in mr images (2002) Hum Brain Mapp., 15, pp. 247-262; Fox, M.D., Snyder, A.Z., Vincent, J.L., Corbetta, M., Van Essen, D.C., Raichle, M.E., The human brain is intrinsically organized into dynamic, anticorrelated functional networks (2005) Proc Natl Acad Sci U S A., 102, pp. 9673-9678; Fogassi, L., Gallese, V., Fadiga, L., Luppino, G., Matelli, M., Rizzolatti, G., Coding of peripersonal space in inferior premotor cortex (area f4) (1996) J Neurophysiol., 76, pp. 141-157; Graziano, M.S., Neuroscience. Awareness of space (2001) Nature., 411, pp. 903-904; Rizzolatti, G., Fogassi, L., Gallese, V., Motor and cognitive functions of the ventral premotor cortex (2002) Curr Opin Neurobiol., 12, pp. 149-154; Bremmer, F., Schlack, A., Shah, N.J., Polymodal motion processing in posterior parietal and premotor cortex: A human fmri study strongly implies equivalencies between humans and monkeys (2001) Neuron., 29, pp. 287-296; Galati, G., Committeri, G., Sanes, J.N., Pizzamiglio, L., Spatial coding of visual and somatic sensory information in bodycentred coordinates (2001) Eur J Neurosci., 14, pp. 737-746; Serino, A., Canzoneri, E., Avenanti, A., Fronto-parietal areas necessary for a multisensory representation of peripersonal space in humans: An rtms study (2011) J Cogn Neurosci., 23, pp. 2956-2967; Newell, K.A., Zavitsanou, K., Jew, S.K., Huang, X.F., Alterations of muscarinic and gaba receptor binding in the posterior cingulate cortex in schizophrenia (2007) Prog Neuropsychopharmacol Biol Psychiatry., 31, pp. 225-233; Caggiano, V., Fogassi, L., Rizzolatti, G., Thier, P., Casile, A., Mirror neurons differentially encode the peripersonal and extrapersonal space of monkeys (2009) Science., 324, pp. 403-406; Uddin, L.Q., Iacoboni, M., Lange, C., Keenan, J.P., The self and social cognition: The role of cortical midline structures and mirror neurons (2007) Trends Cogn Sci., 11, pp. 153-157; Gallese, V., The manifold nature of interpersonal relations: The quest for a common mechanism (2003) Philos Trans R Soc Lond B Biol Sci., 358, pp. 517-528; Parnas, J., From predisposition to psychosis: Progression of symptoms in schizophrenia (1999) Acta Psychiatr Scand., 395, pp. 20-29; Klosterkötter, J., Hellmich, M., Steinmeyer, E.M., Schultze- Lutter, F., Diagnosing schizophrenia in the initial prodromal phase (2001) Arch Gen Psychiatry., 58, pp. 158-164; Schultze-Lutter, F., Subjective symptoms of schizophrenia in research and the clinic: The basic symptom concept (2009) Schizophr Bull., 35, pp. 5-8; Schultze-Lutter, F., Subjective symptoms of schizophrenia in research and the clinic: The basic symptom concept (2009) Schizophr Bull., 35, pp. 5-8; Craig, A.D., How do you feel? Interoception: The sense of the physiological condition of the body (2002) Nat Rev Neurosci., 3, pp. 655-666; Tsakiris, M., Hesse, M.D., Boy, C., Haggard, P., Fink, G.R., Neural signatures of body ownership: A sensory network for bodily self-consciousness (2007) Cereb Cortex., 17, pp. 2235-2244; Karnath, H.O., Baier, B., Nägele, T., Awareness of the functioning of one's own limbs mediated by the insular cortex? (2005) J Neurosci., 25, pp. 7134-7138; Farrer, C., Franck, N., Georgieff, N., Frith, C.D., Decety, J., Jeannerod, M., Modulating the experience of agency: A positron emission tomography study (2003) Neuroimage., 18, pp. 324-333; Heydrich, L., Blanke, O., Distinct illusory own-body perceptions caused by damage to posterior insula and extrastriate cortex (2013) Brain., 136, pp. 790-803; Craig, A.D., How do you feel-now? The anterior insula and human awareness (2009) Nat Rev Neurosci., 10, pp. 59-70; Ebisch, S.J., Ferri, F., Salone, A., Differential involvement of somatosensory and interoceptive cortices during the observation of affective touch (2011) J Cogn Neurosci., 23, pp. 1808-1822; Taylor, K.S., Seminowicz, D.A., Davis, K.D., Two systems of resting state connectivity between the insula and cingulate cortex (2009) Hum Brain Mapp., 30, pp. 2731-2745; Chang, L.J., Yarkoni, T., Khaw, M.W., Sanfey, A.G., Decoding the role of the insula in human cognition: Functional parcellation and large-scale reverse inference (2013) Cereb Cortex., 23, pp. 739-749; Deen, B., Pitskel, N.B., Pelphrey, K.A., Three systems of insular functional connectivity identified with cluster analysis (2011) Cereb Cortex., 21, pp. 1498-1506; Kurth, F., Zilles, K., Fox, P.T., Laird, A.R., Eickhoff, S.B., A link between the systems: Functional differentiation and integration within the human insula revealed by meta-analysis (2010) Brain Struct Funct., 214, pp. 519-534; Critchley, H.D., Wiens, S., Rotshtein, P., Ohman, A., Dolan, R.J., Neural systems supporting interoceptive awareness (2004) Nat Neurosci., 7, pp. 189-195; Damasio, A.R., Grabowski, T.J., Bechara, A., Subcortical and cortical brain activity during the feeling of self-generated emotions (2000) Nat Neurosci., 3, pp. 1049-1056; Wylie, K.P., Tregellas, J.R., The role of the insula in schizophrenia (2010) Schizophr Res., 123, pp. 93-104; Nelson, B., Whitford, T.J., Lavoie, S., Sass, L.A., What are the neurocognitive correlates of basic self-disturbance in schizophrenia? Integrating phenomenology and neurocognition. Source monitoring deficits (2013) Schizophr Res., (PART 1), pp. S0920-9964. , 13 00333-2. doi: 10.1016/j.schres.2013.06.033; Augustine, J.R., Circuitry and functional aspects of the insular lobe in primates including humans (1996) Brain Res Brain Res Rev., 22, pp. 229-244; Mesulam, M.M., Mufson, E.J., Insula of the old world monkey. I. Architectonics in the insulo-orbito-temporal component of the paralimbic brain (1982) J Comp Neurol., 212, pp. 1-22; Sass, L.A., Parnas, J., Schizophrenia, consciousness, and the self (2003) Schizophr Bull., 29, pp. 427-444; Farrer, C., Franck, N., Frith, C.D., Neural correlates of action attribution in schizophrenia (2004) Psychiatry Res., 131, pp. 31-44; Rizzolatti, G., Fogassi, L., Gallese, V., Motor and cognitive functions of the ventral premotor cortex (2002) Curr Opin Neurobiol., 12, pp. 149-154; Northoff, G., What the brain's intrinsic activity can tell us about consciousness? A tri-dimensional view (2013) Neurosci Biobehav Rev., 37, pp. 726-738; Northoff, G., (2013) Unlocking the Brain., 1. , Coding. Oxford, UK: Oxford University Press; Northoff, G., (2013) Unlocking the brain., 2. , Consciousness. Oxford, UK: Oxford University Press; Lui, S., Li, T., Deng, W., Short-term effects of antipsychotic treatment on cerebral function in drug-naive first-episode schizophrenia revealed by "resting state" functional magnetic resonance imaging (2010) Arch Gen Psychiatry., 67, pp. 783-792; Sambataro, F., Blasi, G., Fazio, L., Treatment with olanzapine is associated with modulation of the default mode network in patients with schizophrenia (2010) Neuropsychopharmacology., 35, pp. 904-912
PY - 2014
Y1 - 2014
N2 - Self-experience anomalies are elementary features of schizophrenic pathology. Such deficits can have a profound impact on self-other relationship, but how they are related through aberrant brain function remains poorly understood. In this functional magnetic resonance imaging (fMRI) study, we provide new evidence for a cortical link between aberrant selfexperience and social cognition in first-episode schizophrenia (FES). As identified in previous studies, ventral premotor cortex (vPMC) and posterior insula (pIC) are candidate brain regions underlying disturbances in both self-experience and self-other relationship due to their processing of predominantly externally guided (vPMC; goal-oriented behavior) and internally guided (pIC; interoception) stimuli. Results from functional interaction analysis in a sample of 24 FES patients and 22 healthy controls show aberrant functional interactions (background/intrinsic connectivity) of right vPMC and bilateral pIC with posterior cingulate cortex (PCC), a midline region that has been shown central in mediating self-experience. More specifically, our results show increased functional coupling between vPMC and PCC, which positively correlated with basic symptoms (subjective self-experience disturbances). pIC showed reduced functional coupling with PCC and postcentral gyrus and increased functional interactions with anterior insula. Taken together, our results suggest an imbalance in the processing between internally and externally guided information and its abnormal integration with self-referential processing as mediated by PCC. Due to our correlation findings, we suggest this imbalance to be closely related to basic symptoms in FES and thus anomalous self-experience. The findings further disentangle the cortical basis of how selfexperience anomalies may pervade the social domain. © The Author 2013.
AB - Self-experience anomalies are elementary features of schizophrenic pathology. Such deficits can have a profound impact on self-other relationship, but how they are related through aberrant brain function remains poorly understood. In this functional magnetic resonance imaging (fMRI) study, we provide new evidence for a cortical link between aberrant selfexperience and social cognition in first-episode schizophrenia (FES). As identified in previous studies, ventral premotor cortex (vPMC) and posterior insula (pIC) are candidate brain regions underlying disturbances in both self-experience and self-other relationship due to their processing of predominantly externally guided (vPMC; goal-oriented behavior) and internally guided (pIC; interoception) stimuli. Results from functional interaction analysis in a sample of 24 FES patients and 22 healthy controls show aberrant functional interactions (background/intrinsic connectivity) of right vPMC and bilateral pIC with posterior cingulate cortex (PCC), a midline region that has been shown central in mediating self-experience. More specifically, our results show increased functional coupling between vPMC and PCC, which positively correlated with basic symptoms (subjective self-experience disturbances). pIC showed reduced functional coupling with PCC and postcentral gyrus and increased functional interactions with anterior insula. Taken together, our results suggest an imbalance in the processing between internally and externally guided information and its abnormal integration with self-referential processing as mediated by PCC. Due to our correlation findings, we suggest this imbalance to be closely related to basic symptoms in FES and thus anomalous self-experience. The findings further disentangle the cortical basis of how selfexperience anomalies may pervade the social domain. © The Author 2013.
KW - Connectivity
KW - Functional magnetic resonance imaging
KW - Posterior cingulate cortex
KW - Posterior insula
KW - Psychosis
KW - Ventral premotor cortex
KW - adult
KW - anterior insula
KW - article
KW - BOLD signal
KW - brain region
KW - clinical article
KW - consensus
KW - controlled study
KW - female
KW - functional magnetic resonance imaging
KW - functional neuroimaging
KW - human
KW - insula
KW - left hemisphere
KW - male
KW - personal experience
KW - postcentral gyrus
KW - posterior cingulate
KW - posterior insula
KW - posterior parietal cortex
KW - premotor cortex
KW - priority journal
KW - right hemisphere
KW - schizophrenia
KW - self experience
KW - social cognition
KW - social interaction
KW - somatosensory cortex
KW - brain cortex
KW - cingulate gyrus
KW - connectome
KW - ego
KW - motor cortex
KW - nuclear magnetic resonance imaging
KW - pathophysiology
KW - perception
KW - Adult
KW - Cerebral Cortex
KW - Connectome
KW - Ego
KW - Female
KW - Gyrus Cinguli
KW - Humans
KW - Magnetic Resonance Imaging
KW - Male
KW - Motor Cortex
KW - Schizophrenia
KW - Social Perception
U2 - 10.1093/schbul/sbt153
DO - 10.1093/schbul/sbt153
M3 - Article
C2 - 24191160
SN - 0586-7614
VL - 40
SP - 1072
EP - 1082
JO - Schizophrenia Bulletin
JF - Schizophrenia Bulletin
IS - 5
ER -