Alteration of the tongue manifestation reflects clinical outcomes of peptic ulcer disease

Hwang Huei Wang, Chun Hsu Pan, Ping Ping Wu, Shu Fang Luo, Hung Jen Lin, Chieh Hsi Wu

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Objectives: This study investigated whether the tongue inspection technique in Traditional Chinese Medicine (TCM) can be used as a noninvasive auxiliary diagnostic tool to differentiate the subtypes of peptic ulcer disease (PUD) and as an indicator of therapeutic efficacy. Subjects and methods: A total of 198 outpatients from the China Medical University Hospital were recruited. The control group comprised 50 healthy adults. The remaining 148 patients were diagnosed with gastric ulcer, duodenal ulcer, or Helicobacter pylori (Hp) infection using upper gastrointestinal (GI) endoscopy, biopsy, and Campylobacter-like organism test. Tongue appearance was evaluated by a physician experienced in clinical Chinese medicine. Images of the tongue were immediately recorded using a high-resolution digital camera system. Results: The affected group of 148 patients received an 8-week course of ulcer therapy. Of these, 108 patients infected with Hp were subjected to triple therapy in the first week. Forty-nine of these 108 cases infected with Hp completed secondary examination of upper GI endoscopy and tongue inspection. Forty-one of 49 cases (83.7%) were fully cured of Hp infection. These results showed that the color of the tongue body did not change in the cured patients; however, tongue fur was markedly thinner with a color change to white (p

Original languageEnglish
Pages (from-to)1038-1044
Number of pages7
JournalJournal of Alternative and Complementary Medicine
Issue number11
Publication statusPublished - Nov 1 2012
Externally publishedYes

ASJC Scopus subject areas

  • Complementary and alternative medicine


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