Alpinia zerumbet potentially elevates high-density lipoprotein cholesterol level in hamsters

Li Yun Lin, Chiung Chi Peng, Yu Jing Liang, Wan Ting Yeh, Hui Er Wang, Tung Hsi Yu, Robert Y. Peng

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)


In folkloric plant medicines, Alpinia zerumbet (AZ) has been popularly recognized as an exellent hepatoprotector. To search for a good high-density lipoprotein cholesterol (HDL-C) elevating herbal preparation, we examined AZ for its antioxidant and hypolipidaemic bioactivities, especially its HDL-C elevating activity. AZ seeds contain 0.51% essential oils (SO), which are comprised of monoterpenoids, oxygenated monoterpenoids, sesquiterpenoids, oxygenated sesquiterpenoids, aldehydes, acid, and esters. Gas chromatography/mass spectrometry analysis indicated that most of the monoterpenes and sesquiterpenes were recoverable in pentane eluent, whilst the oxygenated monoterpenoids and sesquiterpenoids remained in ether eluent. The high contents of rutin, quercetin, and polyphenolics in ethanolic extract of AZ seeds exhibit moderate antilipoperoxidative but potent DPPH free radical scavenging bioactivities. Conclusively, both seed powder (SP) and SO are effective hypolipidaemics with amazingly potent HDL-C elevating capabilities. On the basis of hepatoprotectivity, SP is a more feasible hypolipidemic agent as well as a promising HDL-C elevating plant medicine.

Original languageEnglish
Pages (from-to)4435-4443
Number of pages9
JournalJournal of Agricultural and Food Chemistry
Issue number12
Publication statusPublished - Jun 25 2008
Externally publishedYes


  • Alpinia zerumbet seed essential oils
  • Antioxidant hypolipidemics
  • Hamsters
  • HDL
  • Terpenes and sesquiterpenes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Food Science
  • Chemistry (miscellaneous)


Dive into the research topics of 'Alpinia zerumbet potentially elevates high-density lipoprotein cholesterol level in hamsters'. Together they form a unique fingerprint.

Cite this