Allergy symptoms, serum total immunoglobulin E, and risk of head and neck cancer

Hsiao Chen Liao, Shang Yin Wu, Chun Yen Ou, Jenn Ren Hsiao, Jehn Shyun Huang, Sen Tien Tsai, Cheng Chih Huang, Tung Yiu Wong, Wei Ting Lee, Ken Chung Chen, Sheen Yie Fang, Jiunn Liang Wu, Tze Ta Huang, Yuan Hua Wu, Wei Ting Hsueh, Chia Jui Yen, Ming Wei Yang, Forn Chia Lin, Yu Hsuan Lai, Jang Yang ChangChen Lin Lin, Yi Hui Wang, Ya Ling Weng, Han Chien Yang, Yu Shan Chen, Jeffrey S. Chang

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Purpose: Allergy symptoms have been associated with a reduced head and neck cancer (HNC) risk, while elevated blood immunoglobulin E (IgE) levels have been associated with an increased HNC risk. According to the “prophylaxis hypothesis,” allergic reaction is the body’s way of expelling carcinogens. IgE level may be increased by exposure to environmental carcinogens, including alcohol and cigarette smoke. We hypothesized that individuals with elevated serum IgE without allergy symptoms (i.e., asymptomatic atopic) would have the highest HNC risk. Methods: A case–control study of HNC (576 cases and 740 controls) was conducted to evaluate the association between allergy symptoms or serum total IgE and HNC risk and the effect modification of allergy symptoms on the association between serum total IgE and HNC risk. Results: Elevated serum total IgE was associated with a significantly increased HNC risk [odds ratio (OR) 1.71, 95 % confidence interval (CI) 1.21–2.42]. Having allergy symptoms was associated with a significantly reduced HNC risk (OR 0.56, 95 % CI 0.43–0.73). Compared to subjects with normal serum total IgE and no allergy symptoms, asymptomatic atopic individuals had a significantly increased HNC risk (OR 2.12, 95 % CI 1.33–3.35). Conclusions: Our results provided further evidence to support the “prophylaxis hypothesis.” Further investigations regarding the immune profiles of asymptomatic atopic individuals may provide additional clues for the biological mechanisms underlying the association between allergy symptoms, IgE, and HNC risk.

Original languageEnglish
Pages (from-to)1105-1115
Number of pages11
JournalCancer Causes and Control
Issue number9
Publication statusPublished - Sept 2016
Externally publishedYes


  • Allergy
  • Case–control
  • Head and neck cancer
  • Immunoglobulin E

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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