Allergen gene transfer

Shau Ku Huang; Kaw Yan Chua; Kue Hsiung Hsieh

doi:10.1016/S0952-7915(97)80181-1

Allergen gene transfer

Shau Ku Huang, Kaw Yan Chua, Kue Hsiung Hsieh

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

DNA-based immunization induces a biased Th1 immune response, and offers a novel strategy for modulation of the Th2-associated response. Recent studies have provided evidence that antigen-induced allergic responses can be modulated in rodents immunized with plasmid DNAs encoding the sensitizing antigens. Further understanding of the regulatory mechanism involved and optimization of gene transfer/expression systems will assist greatly in proving the clinical utility of this process.

Original language	English
Pages (from-to)	800-804
Number of pages	5
Journal	Current Opinion in Immunology
Volume	9
Issue number	6
DOIs	https://doi.org/10.1016/S0952-7915(97)80181-1
Publication status	Published - Dec 1997
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/S0952-7915(97)80181-1

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title = "Allergen gene transfer",

abstract = "DNA-based immunization induces a biased Th1 immune response, and offers a novel strategy for modulation of the Th2-associated response. Recent studies have provided evidence that antigen-induced allergic responses can be modulated in rodents immunized with plasmid DNAs encoding the sensitizing antigens. Further understanding of the regulatory mechanism involved and optimization of gene transfer/expression systems will assist greatly in proving the clinical utility of this process.",

author = "Huang, {Shau Ku} and Chua, {Kaw Yan} and Hsieh, {Kue Hsiung}",

year = "1997",

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AU - Chua, Kaw Yan

AU - Hsieh, Kue Hsiung

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AB - DNA-based immunization induces a biased Th1 immune response, and offers a novel strategy for modulation of the Th2-associated response. Recent studies have provided evidence that antigen-induced allergic responses can be modulated in rodents immunized with plasmid DNAs encoding the sensitizing antigens. Further understanding of the regulatory mechanism involved and optimization of gene transfer/expression systems will assist greatly in proving the clinical utility of this process.

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DO - 10.1016/S0952-7915(97)80181-1

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Allergen gene transfer

Abstract

ASJC Scopus subject areas

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