All-trans Retinoic Acid Increases Notch1 Transcript Expression in Acute Promyelocytic Leukemia

Jen Tsun Lin; Ming Shiuan Wu; Wei Shu Wang; Chueh Chuan Yen; Tzeon Jye Chiou; Jin Hwang Liu; Mu Hua Yang; Ta Chon Chao; Shu Chaou Chou; Po Min Chen

doi:10.1007/BF02849800

All-trans Retinoic Acid Increases Notch1 Transcript Expression in Acute Promyelocytic Leukemia

Jen Tsun Lin
, Ming Shiuan Wu
, Wei Shu Wang
, Chueh Chuan Yen
, Tzeon Jye Chiou
, Jin Hwang Liu
, Mu Hua Yang
, Ta Chon Chao
, Shu Chaou Chou
, Po Min Chen

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

The effect of all-trans retinoid acid (ATRA) on the expression of Notch1 gene by real-time reverse transcriptase polymerase chain reaction (RT-PCR) in acute promyelocytic leukemia cells (APL), NB4, and HL-60 lacking t(15;17) was studied. The cells were treated with ATRA 0.5 μM for up to 96 hours. The increased transcript level of Notch1 was in concert with that of CD11b in NB4 cells, but not in HL-60 cells. The expression of Notch1 gene might be specific for APL cells. As Notch1 gene is involved in the differentiation and leukemogenesis in lymphoid neoplasm, observations suggest that Notch1 is involved in ATRA-modulated differentiation process in APL.

Original language	English
Pages (from-to)	337-343
Number of pages	7
Journal	Advances in Therapy
Volume	20
Issue number	6
DOIs	https://doi.org/10.1007/BF02849800
Publication status	Published - 2003
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Acute promyelocytic leukemia
Notch1 gene
Retinoid acid

ASJC Scopus subject areas

Pharmacology (medical)

Access to Document

10.1007/BF02849800

Cite this

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title = "All-trans Retinoic Acid Increases Notch1 Transcript Expression in Acute Promyelocytic Leukemia",

abstract = "The effect of all-trans retinoid acid (ATRA) on the expression of Notch1 gene by real-time reverse transcriptase polymerase chain reaction (RT-PCR) in acute promyelocytic leukemia cells (APL), NB4, and HL-60 lacking t(15;17) was studied. The cells were treated with ATRA 0.5 μM for up to 96 hours. The increased transcript level of Notch1 was in concert with that of CD11b in NB4 cells, but not in HL-60 cells. The expression of Notch1 gene might be specific for APL cells. As Notch1 gene is involved in the differentiation and leukemogenesis in lymphoid neoplasm, observations suggest that Notch1 is involved in ATRA-modulated differentiation process in APL.",

keywords = "Acute promyelocytic leukemia, Notch1 gene, Retinoid acid",

author = "Lin, \{Jen Tsun\} and Wu, \{Ming Shiuan\} and Wang, \{Wei Shu\} and Yen, \{Chueh Chuan\} and Chiou, \{Tzeon Jye\} and Liu, \{Jin Hwang\} and Yang, \{Mu Hua\} and Chao, \{Ta Chon\} and Chou, \{Shu Chaou\} and Chen, \{Po Min\}",

year = "2003",

doi = "10.1007/BF02849800",

language = "English",

volume = "20",

pages = "337--343",

journal = "Advances in Therapy",

issn = "0741-238X",

publisher = "Adis",

number = "6",

}

TY - JOUR

T1 - All-trans Retinoic Acid Increases Notch1 Transcript Expression in Acute Promyelocytic Leukemia

AU - Lin, Jen Tsun

AU - Wu, Ming Shiuan

AU - Wang, Wei Shu

AU - Yen, Chueh Chuan

AU - Chiou, Tzeon Jye

AU - Liu, Jin Hwang

AU - Yang, Mu Hua

AU - Chao, Ta Chon

AU - Chou, Shu Chaou

AU - Chen, Po Min

PY - 2003

Y1 - 2003

N2 - The effect of all-trans retinoid acid (ATRA) on the expression of Notch1 gene by real-time reverse transcriptase polymerase chain reaction (RT-PCR) in acute promyelocytic leukemia cells (APL), NB4, and HL-60 lacking t(15;17) was studied. The cells were treated with ATRA 0.5 μM for up to 96 hours. The increased transcript level of Notch1 was in concert with that of CD11b in NB4 cells, but not in HL-60 cells. The expression of Notch1 gene might be specific for APL cells. As Notch1 gene is involved in the differentiation and leukemogenesis in lymphoid neoplasm, observations suggest that Notch1 is involved in ATRA-modulated differentiation process in APL.

AB - The effect of all-trans retinoid acid (ATRA) on the expression of Notch1 gene by real-time reverse transcriptase polymerase chain reaction (RT-PCR) in acute promyelocytic leukemia cells (APL), NB4, and HL-60 lacking t(15;17) was studied. The cells were treated with ATRA 0.5 μM for up to 96 hours. The increased transcript level of Notch1 was in concert with that of CD11b in NB4 cells, but not in HL-60 cells. The expression of Notch1 gene might be specific for APL cells. As Notch1 gene is involved in the differentiation and leukemogenesis in lymphoid neoplasm, observations suggest that Notch1 is involved in ATRA-modulated differentiation process in APL.

KW - Acute promyelocytic leukemia

KW - Notch1 gene

KW - Retinoid acid

UR - https://www.scopus.com/pages/publications/12144288252

UR - https://www.scopus.com/pages/publications/12144288252#tab=citedBy

U2 - 10.1007/BF02849800

DO - 10.1007/BF02849800

M3 - Article

C2 - 15058751

AN - SCOPUS:12144288252

SN - 0741-238X

VL - 20

SP - 337

EP - 343

JO - Advances in Therapy

JF - Advances in Therapy

IS - 6

ER -

All-trans Retinoic Acid Increases Notch1 Transcript Expression in Acute Promyelocytic Leukemia

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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