Aliphatic phenolic ethers from trichobotrys effusa

Jih Jung Chen; Shih Wei Wang; Hui Yun Hsiao; Ming Shian Lee; Yu Min Ju; Yueh Hsiung Kuo; Zong-Huei Li

doi:10.1021/np400776y

Aliphatic phenolic ethers from trichobotrys effusa

Jih Jung Chen, Shih Wei Wang, Hui Yun Hsiao, Ming Shian Lee, Yu Min Ju, Yueh Hsiung Kuo, Zong-Huei Li

Graduate Institute of Pharmacognosy

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Four novel aliphatic phenolic ethers, namely, trichoethers A-D (1-4), possessing a unique C₁₁-O-C₁₀ skeleton, together with coriloxin, zythiostromic acid A, radicicol, and 3,5-dihydroxytoluene were isolated from the ethyl acetate extracts of the fermented broths of Trichobotrys effusa YMJ1179. The structures of all the compounds were determined based on spectroscopic data analysis. The configurations of 1-4 were established by J values and NOESY and compared with published data. Compounds 1-4 and radicicol exhibited growth-inhibitory activities against the A549 non-small-cell lung cancer cell line with GI₅₀ values of 25.61, 19.32, 16.19, 24.31, and 1.43 μM, respectively, in comparison with 5-fluorouracil (GI₅₀ = 4.55 μM).

Original language	English
Pages (from-to)	1097-1101
Number of pages	5
Journal	Journal of Natural Products
Volume	77
Issue number	5
DOIs	https://doi.org/10.1021/np400776y
Publication status	Published - May 23 2014

ASJC Scopus subject areas

Drug Discovery
Pharmacology
Pharmaceutical Science
Analytical Chemistry
Organic Chemistry
Molecular Medicine
Complementary and alternative medicine

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/np400776y

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title = "Aliphatic phenolic ethers from trichobotrys effusa",

abstract = "Four novel aliphatic phenolic ethers, namely, trichoethers A-D (1-4), possessing a unique C11-O-C10 skeleton, together with coriloxin, zythiostromic acid A, radicicol, and 3,5-dihydroxytoluene were isolated from the ethyl acetate extracts of the fermented broths of Trichobotrys effusa YMJ1179. The structures of all the compounds were determined based on spectroscopic data analysis. The configurations of 1-4 were established by J values and NOESY and compared with published data. Compounds 1-4 and radicicol exhibited growth-inhibitory activities against the A549 non-small-cell lung cancer cell line with GI50 values of 25.61, 19.32, 16.19, 24.31, and 1.43 μM, respectively, in comparison with 5-fluorouracil (GI50 = 4.55 μM).",

author = "Chen, {Jih Jung} and Wang, {Shih Wei} and Hsiao, {Hui Yun} and Lee, {Ming Shian} and Ju, {Yu Min} and Kuo, {Yueh Hsiung} and Zong-Huei Li",

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T1 - Aliphatic phenolic ethers from trichobotrys effusa

AU - Chen, Jih Jung

AU - Wang, Shih Wei

AU - Hsiao, Hui Yun

AU - Lee, Ming Shian

AU - Ju, Yu Min

AU - Kuo, Yueh Hsiung

AU - Li, Zong-Huei

PY - 2014/5/23

Y1 - 2014/5/23

N2 - Four novel aliphatic phenolic ethers, namely, trichoethers A-D (1-4), possessing a unique C11-O-C10 skeleton, together with coriloxin, zythiostromic acid A, radicicol, and 3,5-dihydroxytoluene were isolated from the ethyl acetate extracts of the fermented broths of Trichobotrys effusa YMJ1179. The structures of all the compounds were determined based on spectroscopic data analysis. The configurations of 1-4 were established by J values and NOESY and compared with published data. Compounds 1-4 and radicicol exhibited growth-inhibitory activities against the A549 non-small-cell lung cancer cell line with GI50 values of 25.61, 19.32, 16.19, 24.31, and 1.43 μM, respectively, in comparison with 5-fluorouracil (GI50 = 4.55 μM).

AB - Four novel aliphatic phenolic ethers, namely, trichoethers A-D (1-4), possessing a unique C11-O-C10 skeleton, together with coriloxin, zythiostromic acid A, radicicol, and 3,5-dihydroxytoluene were isolated from the ethyl acetate extracts of the fermented broths of Trichobotrys effusa YMJ1179. The structures of all the compounds were determined based on spectroscopic data analysis. The configurations of 1-4 were established by J values and NOESY and compared with published data. Compounds 1-4 and radicicol exhibited growth-inhibitory activities against the A549 non-small-cell lung cancer cell line with GI50 values of 25.61, 19.32, 16.19, 24.31, and 1.43 μM, respectively, in comparison with 5-fluorouracil (GI50 = 4.55 μM).

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Aliphatic phenolic ethers from trichobotrys effusa

Abstract

ASJC Scopus subject areas

UN SDGs

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