TY - JOUR
T1 - Alcohol-metabolising genes and alcoholism among Taiwanese Han men
T2 - Independent effect of ADH2, ADH3 and ALDH2
AU - Chen, Wei J.
AU - Loh, E. W.
AU - Hsu, Yun Pung P.
AU - Chen, Chiao Chicy
AU - Yu, Jeng Ming
AU - Cheng, Andrew T.A.
PY - 1996
Y1 - 1996
N2 - Background. Previous population association studies have indicated that certain alleles of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) may reduce the risk of alcoholism in Asian populations. The association of ALDH2 and ADH2 with the development of alcoholism was found to be independent of each other and has been replicated in different Asian populations, while the effect of ADH3 is less studied. Method. We genotyped the alcohol metabolism genes among Han men with alcohol dependence (n = 46) and their ethnically matched normal controls (n = 63) in Taiwan. Multiple logistic regression was then applied to assess the contribution of ADH3 to alcoholism by controlling the effect of ALDH2 and ADH2. Results. The results of multivariate analyses demonstrated that the odds ratios for an increment of one allele of ADH2*1, ADH3*2 and ALDH2*1 in the development of alcoholism were 4.18, 3.82, and 6.89, respectively. Conclusions. These findings clearly indicate that all three alcohol-metabolising genes contribute to susceptibility to alcoholism.
AB - Background. Previous population association studies have indicated that certain alleles of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) may reduce the risk of alcoholism in Asian populations. The association of ALDH2 and ADH2 with the development of alcoholism was found to be independent of each other and has been replicated in different Asian populations, while the effect of ADH3 is less studied. Method. We genotyped the alcohol metabolism genes among Han men with alcohol dependence (n = 46) and their ethnically matched normal controls (n = 63) in Taiwan. Multiple logistic regression was then applied to assess the contribution of ADH3 to alcoholism by controlling the effect of ALDH2 and ADH2. Results. The results of multivariate analyses demonstrated that the odds ratios for an increment of one allele of ADH2*1, ADH3*2 and ALDH2*1 in the development of alcoholism were 4.18, 3.82, and 6.89, respectively. Conclusions. These findings clearly indicate that all three alcohol-metabolising genes contribute to susceptibility to alcoholism.
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U2 - 10.1192/bjp.168.6.762
DO - 10.1192/bjp.168.6.762
M3 - Article
C2 - 8773821
AN - SCOPUS:0029890628
SN - 0007-1250
VL - 168
SP - 762
EP - 767
JO - British Journal of Psychiatry
JF - British Journal of Psychiatry
IS - JUNE
ER -
