Albumin batches and B19 parvovirus DNA

J. J. Lefrère; I. de la Croix; J. Lerable; M. Thauvin; T. Burnouf; G. Folléa

doi:10.1046/j.1537-2995.1995.35595259148.x

Albumin batches and B19 parvovirus DNA

J. J. Lefrère, I. de la Croix, J. Lerable, M. Thauvin, T. Burnouf, G. Folléa

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Background: B19 parvovirus (B19) maybe transmitted iatrogenically by blood, and its prevalence in blood donations is estimated at 1 in 3,300 to 1 in 50,000. As a large number of blood donations make up the plasma pools used to produce plasma derivatives, even a virus as rare as B19 in a population of blood donors may result in the frequent contamination of plasma batches. The percentage of albumin batches containing B19 DNA has never been determined. Study Design and Methods: The presence of B19 DNA was investigated by a polymerase chain reaction assay (with a primer pair in the VP1 region) in a total of 12 and 17 batches of 4- and 20-percent albumin, respectively, from two different manufacturers. Results: No B19 DNA was detected in the batches tested. Conclusion: The current fractionation process used to obtain these albumin preparations is seen to allow the efficient degradation and/or elimination of B19.

Original language	English
Pages (from-to)	389-391
Number of pages	3
Journal	Transfusion
Volume	35
Issue number	5
DOIs	https://doi.org/10.1046/j.1537-2995.1995.35595259148.x
Publication status	Published - May 1995
Externally published	Yes

ASJC Scopus subject areas

Hematology
Immunology and Allergy
Immunology

Access to Document

10.1046/j.1537-2995.1995.35595259148.x

Cite this

@article{6b8804b50e0b4d1d90e6abf4f8f335c6,

title = "Albumin batches and B19 parvovirus DNA",

abstract = "Background: B19 parvovirus (B19) maybe transmitted iatrogenically by blood, and its prevalence in blood donations is estimated at 1 in 3,300 to 1 in 50,000. As a large number of blood donations make up the plasma pools used to produce plasma derivatives, even a virus as rare as B19 in a population of blood donors may result in the frequent contamination of plasma batches. The percentage of albumin batches containing B19 DNA has never been determined. Study Design and Methods: The presence of B19 DNA was investigated by a polymerase chain reaction assay (with a primer pair in the VP1 region) in a total of 12 and 17 batches of 4- and 20-percent albumin, respectively, from two different manufacturers. Results: No B19 DNA was detected in the batches tested. Conclusion: The current fractionation process used to obtain these albumin preparations is seen to allow the efficient degradation and/or elimination of B19.",

author = "Lefr{\`e}re, {J. J.} and {de la Croix}, I. and J. Lerable and M. Thauvin and T. Burnouf and G. Foll{\'e}a",

year = "1995",

month = may,

doi = "10.1046/j.1537-2995.1995.35595259148.x",

language = "English",

volume = "35",

pages = "389--391",

journal = "Transfusion",

issn = "0041-1132",

publisher = "Wiley-Blackwell",

number = "5",

}

TY - JOUR

T1 - Albumin batches and B19 parvovirus DNA

AU - Lefrère, J. J.

AU - de la Croix, I.

AU - Lerable, J.

AU - Thauvin, M.

AU - Burnouf, T.

AU - Folléa, G.

PY - 1995/5

Y1 - 1995/5

N2 - Background: B19 parvovirus (B19) maybe transmitted iatrogenically by blood, and its prevalence in blood donations is estimated at 1 in 3,300 to 1 in 50,000. As a large number of blood donations make up the plasma pools used to produce plasma derivatives, even a virus as rare as B19 in a population of blood donors may result in the frequent contamination of plasma batches. The percentage of albumin batches containing B19 DNA has never been determined. Study Design and Methods: The presence of B19 DNA was investigated by a polymerase chain reaction assay (with a primer pair in the VP1 region) in a total of 12 and 17 batches of 4- and 20-percent albumin, respectively, from two different manufacturers. Results: No B19 DNA was detected in the batches tested. Conclusion: The current fractionation process used to obtain these albumin preparations is seen to allow the efficient degradation and/or elimination of B19.

AB - Background: B19 parvovirus (B19) maybe transmitted iatrogenically by blood, and its prevalence in blood donations is estimated at 1 in 3,300 to 1 in 50,000. As a large number of blood donations make up the plasma pools used to produce plasma derivatives, even a virus as rare as B19 in a population of blood donors may result in the frequent contamination of plasma batches. The percentage of albumin batches containing B19 DNA has never been determined. Study Design and Methods: The presence of B19 DNA was investigated by a polymerase chain reaction assay (with a primer pair in the VP1 region) in a total of 12 and 17 batches of 4- and 20-percent albumin, respectively, from two different manufacturers. Results: No B19 DNA was detected in the batches tested. Conclusion: The current fractionation process used to obtain these albumin preparations is seen to allow the efficient degradation and/or elimination of B19.

UR - http://www.scopus.com/inward/record.url?scp=0029002859&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029002859&partnerID=8YFLogxK

U2 - 10.1046/j.1537-2995.1995.35595259148.x

DO - 10.1046/j.1537-2995.1995.35595259148.x

M3 - Article

C2 - 7740609

AN - SCOPUS:0029002859

SN - 0041-1132

VL - 35

SP - 389

EP - 391

JO - Transfusion

JF - Transfusion

IS - 5

ER -

Albumin batches and B19 parvovirus DNA

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this