Aging modulates the substrate and triggers remodeling in atrial fibrillation

Yung Kuo Lin, Yi Ann Chen, Ting I. Lee, Yao Chang Chen, Shih Ann Chen, Yi Jen Chen

Research output: Contribution to journalReview articlepeer-review

20 Citations (Scopus)


Aging plays a critical role in the genesis of atrial fibrillation (AF) and also increases the risks of cardiac dysfunction and stroke in AF patients. AF is caused by increased AF triggering from abnormalities of the thoracic vein and/or modulated substrate (atrial) with enhancement of AF maintenance. Clinical and laboratory evidence indicates that aging is significant in the creation of atrial electrical and structural remodeling that leads to increased susceptibility to AF occurrence. Aging is commonly associated with cardiovascular comorbidities, oxidative stress, calcium dysregulation, atrial myopathy with apoptosis, and fibrosis, which all contribute to the genesis of AF. This review updates the current understanding of the effects of aging on the pathophysiology of AF.

Original languageEnglish
Pages (from-to)1237-1244
Number of pages8
JournalCirculation Journal
Issue number5
Publication statusPublished - Jan 1 2018


  • Aging
  • Atria
  • Atrial fibrillation
  • Pulmonary veins

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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