Ag/Au bi-metallic film based color surface plasmon resonance biosensor with enhanced sensitivity, color contrast and great linearity

Chung Tien Li; Kun Chi Lo; Hsin Yun Chang; Hsieh Ting Wu; Jennifer H. Ho; Ta Jen Yen

doi:10.1016/j.bios.2012.04.016

Ag/Au bi-metallic film based color surface plasmon resonance biosensor with enhanced sensitivity, color contrast and great linearity

Chung Tien Li, Kun Chi Lo, Hsin Yun Chang, Hsieh Ting Wu, Jennifer H. Ho, Ta Jen Yen

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

In wavelength surface plasmon resonance (SPR) biosensor, the manipulation of SPR dispersion relation by Ag/Au bi-metallic film was first time implemented. Due to the enhanced resonant wavelength shift and the sharper SPR slope of using Ag/Au bi-metallic film, the illuminated color of reflection shows one order of magnitude greater contrast than conventional SPR biosensors. Such an Ag/Au bi-metallic film based color SPR biosensor (CSPRB) allows the detail bio-interactions, for example 100. nM streptavidin, to be distinguished by directly observing the color change of reflection through naked eyes rather than the analysis of spectrometer. In addition to the enhanced sensitivity and color contrast, this CSPRB also possesses a great linear detection range up to 0.0254. RIU, which leading to the application of point-of-care tests.

Original language	English
Pages (from-to)	192-198
Number of pages	7
Journal	Biosensors and Bioelectronics
Volume	36
Issue number	1
DOIs	https://doi.org/10.1016/j.bios.2012.04.016
Publication status	Published - Jun 2012

Keywords

Bi-metallic film
Color contrast
Linear detection range
Sensitivity
Surface plasmon resonance

ASJC Scopus subject areas

Biotechnology
Biophysics
Biomedical Engineering
Electrochemistry

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10.1016/j.bios.2012.04.016

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title = "Ag/Au bi-metallic film based color surface plasmon resonance biosensor with enhanced sensitivity, color contrast and great linearity",

abstract = "In wavelength surface plasmon resonance (SPR) biosensor, the manipulation of SPR dispersion relation by Ag/Au bi-metallic film was first time implemented. Due to the enhanced resonant wavelength shift and the sharper SPR slope of using Ag/Au bi-metallic film, the illuminated color of reflection shows one order of magnitude greater contrast than conventional SPR biosensors. Such an Ag/Au bi-metallic film based color SPR biosensor (CSPRB) allows the detail bio-interactions, for example 100. nM streptavidin, to be distinguished by directly observing the color change of reflection through naked eyes rather than the analysis of spectrometer. In addition to the enhanced sensitivity and color contrast, this CSPRB also possesses a great linear detection range up to 0.0254. RIU, which leading to the application of point-of-care tests.",

keywords = "Bi-metallic film, Color contrast, Linear detection range, Sensitivity, Surface plasmon resonance",

author = "Li, {Chung Tien} and Lo, {Kun Chi} and Chang, {Hsin Yun} and Wu, {Hsieh Ting} and Ho, {Jennifer H.} and Yen, {Ta Jen}",

note = "Funding Information: The authors would like to gratefully acknowledge the financial support from the National Science Council ( NSC98-2112-M-007-002-MY3 , NSC100-2120-M-002-008 , and NSC100-2120-M-010-001 ), and from the Ministry of Education (“Aim for the Top University Plan” for National Tsing Hua University). ",

year = "2012",

month = jun,

doi = "10.1016/j.bios.2012.04.016",

language = "English",

volume = "36",

pages = "192--198",

journal = "Biosensors and Bioelectronics",

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AU - Li, Chung Tien

AU - Lo, Kun Chi

AU - Chang, Hsin Yun

AU - Wu, Hsieh Ting

AU - Ho, Jennifer H.

AU - Yen, Ta Jen

N1 - Funding Information: The authors would like to gratefully acknowledge the financial support from the National Science Council ( NSC98-2112-M-007-002-MY3 , NSC100-2120-M-002-008 , and NSC100-2120-M-010-001 ), and from the Ministry of Education (“Aim for the Top University Plan” for National Tsing Hua University).

PY - 2012/6

Y1 - 2012/6

N2 - In wavelength surface plasmon resonance (SPR) biosensor, the manipulation of SPR dispersion relation by Ag/Au bi-metallic film was first time implemented. Due to the enhanced resonant wavelength shift and the sharper SPR slope of using Ag/Au bi-metallic film, the illuminated color of reflection shows one order of magnitude greater contrast than conventional SPR biosensors. Such an Ag/Au bi-metallic film based color SPR biosensor (CSPRB) allows the detail bio-interactions, for example 100. nM streptavidin, to be distinguished by directly observing the color change of reflection through naked eyes rather than the analysis of spectrometer. In addition to the enhanced sensitivity and color contrast, this CSPRB also possesses a great linear detection range up to 0.0254. RIU, which leading to the application of point-of-care tests.

AB - In wavelength surface plasmon resonance (SPR) biosensor, the manipulation of SPR dispersion relation by Ag/Au bi-metallic film was first time implemented. Due to the enhanced resonant wavelength shift and the sharper SPR slope of using Ag/Au bi-metallic film, the illuminated color of reflection shows one order of magnitude greater contrast than conventional SPR biosensors. Such an Ag/Au bi-metallic film based color SPR biosensor (CSPRB) allows the detail bio-interactions, for example 100. nM streptavidin, to be distinguished by directly observing the color change of reflection through naked eyes rather than the analysis of spectrometer. In addition to the enhanced sensitivity and color contrast, this CSPRB also possesses a great linear detection range up to 0.0254. RIU, which leading to the application of point-of-care tests.

KW - Bi-metallic film

KW - Color contrast

KW - Linear detection range

KW - Sensitivity

KW - Surface plasmon resonance

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Ag/Au bi-metallic film based color surface plasmon resonance biosensor with enhanced sensitivity, color contrast and great linearity

Abstract

Keywords

ASJC Scopus subject areas

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