Advances in mesenchymal stem cell therapy for immune and inflammatory diseases: Use of cell-free products and human pluripotent stem cell-derived mesenchymal stem cells

Li Tzu Wang, Ko Jiunn Liu, Huey Kang Sytwu, Men Luh Yen, B. Linju Yen

Research output: Contribution to journalReview articlepeer-review

61 Citations (Scopus)

Abstract

Mesenchymal stem cell therapy (MSCT) for immune and inflammatory diseases continues to be popular based on progressive accumulation of preclinical mechanistic evidence. This has led to further expansion in clinical indications from graft rejection, autoimmune diseases, and osteoarthritis, to inflammatory liver and pulmonary diseases including COVID-19. A clear trend is the shift from using autologous to allogeneic MSCs, which can be immediately available as off-the-shelf products. In addition, new products such as cell-free exosomes and human pluripotent stem cell (hPSC)-derived MSCs are exciting developments to further prevalent use. Increasing numbers of trials have now published results in which safety of MSCT has been largely demonstrated. While reports of therapeutic endpoints are still emerging, efficacy can be seen for specific indications—including graft-vs-host-disease, strongly Th17-mediated autoimmune diseases, and osteoarthritis—which are more robustly supported by mechanistic preclinical evidence. In this review, we update and discuss outcomes in current MSCT clinical trials for immune and inflammatory disease, as well as new innovation and emerging trends in the field.

Original languageEnglish
Pages (from-to)1288-1303
Number of pages16
JournalStem cells translational medicine
Volume10
Issue number9
DOIs
Publication statusPublished - Sept 2021
Externally publishedYes

Keywords

  • autoimmune diseases
  • clinical trials
  • exosomes
  • extracellular vesicles
  • graft rejection
  • human
  • human pluripotent stem cells
  • liver cirrhosis
  • mesenchymal stem/stromal cell therapy
  • organ transplantation
  • pulmonary inflammation

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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