Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 30-39 |
| Number of pages | 10 |
| Journal | Pharmacogenomics Journal |
| Volume | 10 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2010 |
| Externally published | Yes |
Keywords
- ADR
- ADRA1A gene
- Antipsychotics
- BMI
- Obesity
- Schizophrenia
- alpha 1A adrenergic receptor
- atypical antipsychotic agent
- neuroleptic agent
- adult
- article
- body mass
- controlled study
- diabetes mellitus
- DNA determination
- female
- gene frequency
- gene interaction
- genetic association
- genotype
- human
- intron
- major clinical study
- male
- pharmacogenetics
- priority journal
- promoter region
- schizophrenia
- side effect
- single nucleotide polymorphism
- weight gain
- Adult
- Aged
- Aged, 80 and over
- Antipsychotic Agents
- Base Sequence
- Body Mass Index
- Female
- Humans
- Linkage Disequilibrium
- Male
- Middle Aged
- Polymorphism, Single Nucleotide
- Prospective Studies
- Receptors, Adrenergic, alpha-1
- Weight Gain
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ADRA1A gene is associated with BMI in chronic schizophrenia patients exposed to antipsychotics. / Liu, Yun-Ru; Loh, El-Wui; Lan, Tsuo-Hung et al.
In: Pharmacogenomics Journal, Vol. 10, No. 1, 2010, p. 30-39.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - ADRA1A gene is associated with BMI in chronic schizophrenia patients exposed to antipsychotics
AU - Liu, Yun-Ru
AU - Loh, El-Wui
AU - Lan, Tsuo-Hung
AU - Chen, Shuo-Fei
AU - Yu, Yen-Hsin
AU - Chang, Yung-Han
AU - Huang, Chun-Jung
AU - Hu, Tsung-Ming
AU - Lin, Keh-Ming
AU - Yao, Yu-Tung
AU - Chiu, Hsien-Jane
N1 - 被引用次數：14 Export Date: 29 March 2016 CODEN: PJHOA 通訊地址: Chiu, H.-J.; Department of Health, Jianan Mental Hospital, 80, Lane 870, Jhung-Shan Road, Rende Township, Tainan 717, Taiwan; 電子郵件： chiu8@mail2000.com.tw 化學物質/CAS: Antipsychotic Agents; Receptors, Adrenergic, alpha-1; adrenergic receptor alpha(1a) 參考文獻: Aronne, L.J., Epidemiology, morbidity, and treatment of overweight and obesity (2001) J Clin Psychiatry, 62 (SUPPL. 23), pp. 13-22; Hsiao, C.C., Ree, S.C., Chiang, Y.L., Yeh, S.S., Chen, C.K., Obesity in schizophrenic outpatients receiving antipsychotics in Taiwan (2004) Psychiatry Clin Neurosci, 58, pp. 403-409; Newcomer, J.W., Metabolic considerations in the use of antipsychotic medications: A review of recent evidence (2007) J Clin Psychiatry, 68 (SUPPL. 1), pp. 20-27; Reinholz, J., Skopp, O., Breitenstein, C., Bohr, I., Winterhoff, H., Knecht, S., Compensatory weight gain due to dopaminergic hypofunction: New evidence and own incidental observations (2008) Nutr Metab (Lond), 5, p. 35; Leibowitz, S.F., Alexander, J.T., Hypothalamic serotonin in control of eating behavior, meal size, and body weight (1998) Biol Psychiatry, 44, pp. 851-864; Templeman, L.A., Reynolds, G.P., Arranz, B., San, L., Polymorphisms of the 5-HT2C receptor and leptin genes are associated with antipsychotic drug-induced weight gain in Caucasian subjects with a first episode psychosis (2005) Pharmacogenet Genomics, 15, pp. 195-200; Correll, C.U., Malhotra, A.K., Pharmacogenetics of antipsychotic-induced weight gain (2004) Psychopharmacology (Berl), 174, pp. 477-489; Müller, D.J., Muglia, P., Fortune, T., Kennedy, J.L., Pharmacogenetics of antipsychotic-induced weight gain (2004) Pharmacol Res, 49, pp. 309-329; Chagnon, Y.C., Susceptibility genes for the side effect of antipsychotics on body weight and obesity (2006) Curr Drug Targets, 7, pp. 1681-1695; Bray, G.A., Obesity, a disorder of nutrient partitioning: The MONA LISA hypothesis (1991) J Nutr, 121, pp. 1146-1162; Fain, J.N., Garcija-Sainz, J.A., Adrenergic regulation of adipocyte metabolism (1983) J Lipid Res, 24, pp. 945-966; 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PY - 2010
Y1 - 2010
N2 - Noradrenaline and adrenaline are neurotransmitters of the sympathetic nervous system that interact with various adrenergic receptor (ADR) subtypes, and this regulates the basal metabolic rate, thermogenesis and efficiency of energy utilization. We examined a possible role of the gene coding for ADRA1A receptor in weight gain in schizophrenia subjects exposed to antipsychotics. A total of 401 schizophrenia in-patients treated with antipsychotics for 2 years were recruited and a final 394 DNA samples were genotyped. Their body mass indexes (BMIs) were recorded for 12 months and parameterized to be correlated in regression. Among the 58 single-nucleotide polymorphisms (SNPs) genotyped, 44 valid SNPs, which had minor allele frequency 0.03, were analyzed in statistics. Linear regression model with age, gender, diabetes, use of typical antipsychotics and use of atypical antipsychotics as covariates, with or without gender interaction, showed evidence of associations between the ADRA1A gene and BMI. Most of the SNPs associated with BMI are located in the promoter and intron regions, and being female appeared to enhance the gene effect. Our study suggests that the ADRA1A gene is involved in weight gain among schizophrenia patients treated with antipsychotics. Further molecular dissection of the ADRA1A gene warrants better understanding on weight gain mechanisms in schizophrenia. © 2010 Nature Publishing Group All rights reserved.
AB - Noradrenaline and adrenaline are neurotransmitters of the sympathetic nervous system that interact with various adrenergic receptor (ADR) subtypes, and this regulates the basal metabolic rate, thermogenesis and efficiency of energy utilization. We examined a possible role of the gene coding for ADRA1A receptor in weight gain in schizophrenia subjects exposed to antipsychotics. A total of 401 schizophrenia in-patients treated with antipsychotics for 2 years were recruited and a final 394 DNA samples were genotyped. Their body mass indexes (BMIs) were recorded for 12 months and parameterized to be correlated in regression. Among the 58 single-nucleotide polymorphisms (SNPs) genotyped, 44 valid SNPs, which had minor allele frequency 0.03, were analyzed in statistics. Linear regression model with age, gender, diabetes, use of typical antipsychotics and use of atypical antipsychotics as covariates, with or without gender interaction, showed evidence of associations between the ADRA1A gene and BMI. Most of the SNPs associated with BMI are located in the promoter and intron regions, and being female appeared to enhance the gene effect. Our study suggests that the ADRA1A gene is involved in weight gain among schizophrenia patients treated with antipsychotics. Further molecular dissection of the ADRA1A gene warrants better understanding on weight gain mechanisms in schizophrenia. © 2010 Nature Publishing Group All rights reserved.
KW - ADR
KW - ADRA1A gene
KW - Antipsychotics
KW - BMI
KW - Obesity
KW - Schizophrenia
KW - alpha 1A adrenergic receptor
KW - atypical antipsychotic agent
KW - neuroleptic agent
KW - adult
KW - article
KW - body mass
KW - controlled study
KW - diabetes mellitus
KW - DNA determination
KW - female
KW - gene frequency
KW - gene interaction
KW - genetic association
KW - genotype
KW - human
KW - intron
KW - major clinical study
KW - male
KW - pharmacogenetics
KW - priority journal
KW - promoter region
KW - schizophrenia
KW - side effect
KW - single nucleotide polymorphism
KW - weight gain
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Antipsychotic Agents
KW - Base Sequence
KW - Body Mass Index
KW - Female
KW - Humans
KW - Linkage Disequilibrium
KW - Male
KW - Middle Aged
KW - Polymorphism, Single Nucleotide
KW - Prospective Studies
KW - Receptors, Adrenergic, alpha-1
KW - Weight Gain
UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-75549092068&partnerID=40&md5=54f2a987ec5de3f9dbfdc1322f758fd7
UR - https://www.scopus.com/results/citedbyresults.uri?sort=plf-f&cite=2-s2.0-75549092068&src=s&imp=t&sid=ebdd0811fe5e96e4b5afac9055139f5c&sot=cite&sdt=a&sl=0&origin=recordpage&editSaveSearch=&txGid=d924ec2f08638a976169fe5a12a84bc3
U2 - 10.1038/tpj.2009.55
DO - 10.1038/tpj.2009.55
M3 - Article
SN - 1470-269X
VL - 10
SP - 30
EP - 39
JO - Pharmacogenomics Journal
JF - Pharmacogenomics Journal
IS - 1
ER -