Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 30-39 |
| Number of pages | 10 |
| Journal | Pharmacogenomics Journal |
| Volume | 10 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2010 |
| Externally published | Yes |
Keywords
- ADR
- ADRA1A gene
- Antipsychotics
- BMI
- Obesity
- Schizophrenia
- alpha 1A adrenergic receptor
- atypical antipsychotic agent
- neuroleptic agent
- adult
- article
- body mass
- controlled study
- diabetes mellitus
- DNA determination
- female
- gene frequency
- gene interaction
- genetic association
- genotype
- human
- intron
- major clinical study
- male
- pharmacogenetics
- priority journal
- promoter region
- schizophrenia
- side effect
- single nucleotide polymorphism
- weight gain
- Adult
- Aged
- Aged, 80 and over
- Antipsychotic Agents
- Base Sequence
- Body Mass Index
- Female
- Humans
- Linkage Disequilibrium
- Male
- Middle Aged
- Polymorphism, Single Nucleotide
- Prospective Studies
- Receptors, Adrenergic, alpha-1
- Weight Gain
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In: Pharmacogenomics Journal, Vol. 10, No. 1, 2010, p. 30-39.
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}
TY - JOUR
T1 - ADRA1A gene is associated with BMI in chronic schizophrenia patients exposed to antipsychotics
AU - Liu, Yun-Ru
AU - Loh, El-Wui
AU - Lan, Tsuo-Hung
AU - Chen, Shuo-Fei
AU - Yu, Yen-Hsin
AU - Chang, Yung-Han
AU - Huang, Chun-Jung
AU - Hu, Tsung-Ming
AU - Lin, Keh-Ming
AU - Yao, Yu-Tung
AU - Chiu, Hsien-Jane
N1 - 被引用次數：14 Export Date: 29 March 2016 CODEN: PJHOA 通訊地址: Chiu, H.-J.; Department of Health, Jianan Mental Hospital, 80, Lane 870, Jhung-Shan Road, Rende Township, Tainan 717, Taiwan; 電子郵件： [email protected] 化學物質/CAS: Antipsychotic Agents; Receptors, Adrenergic, alpha-1; adrenergic receptor alpha(1a) 參考文獻: Aronne, L.J., Epidemiology, morbidity, and treatment of overweight and obesity (2001) J Clin Psychiatry, 62 (SUPPL. 23), pp. 13-22; Hsiao, C.C., Ree, S.C., Chiang, Y.L., Yeh, S.S., Chen, C.K., Obesity in schizophrenic outpatients receiving antipsychotics in Taiwan (2004) Psychiatry Clin Neurosci, 58, pp. 403-409; Newcomer, J.W., Metabolic considerations in the use of antipsychotic medications: A review of recent evidence (2007) J Clin Psychiatry, 68 (SUPPL. 1), pp. 20-27; Reinholz, J., Skopp, O., Breitenstein, C., Bohr, I., Winterhoff, H., Knecht, S., Compensatory weight gain due to dopaminergic hypofunction: New evidence and own incidental observations (2008) Nutr Metab (Lond), 5, p. 35; Leibowitz, S.F., Alexander, J.T., Hypothalamic serotonin in control of eating behavior, meal size, and body weight (1998) Biol Psychiatry, 44, pp. 851-864; Templeman, L.A., Reynolds, G.P., Arranz, B., San, L., Polymorphisms of the 5-HT2C receptor and leptin genes are associated with antipsychotic drug-induced weight gain in Caucasian subjects with a first episode psychosis (2005) Pharmacogenet Genomics, 15, pp. 195-200; Correll, C.U., Malhotra, A.K., Pharmacogenetics of antipsychotic-induced weight gain (2004) Psychopharmacology (Berl), 174, pp. 477-489; Müller, D.J., Muglia, P., Fortune, T., Kennedy, J.L., Pharmacogenetics of antipsychotic-induced weight gain (2004) Pharmacol Res, 49, pp. 309-329; Chagnon, Y.C., Susceptibility genes for the side effect of antipsychotics on body weight and obesity (2006) Curr Drug Targets, 7, pp. 1681-1695; Bray, G.A., Obesity, a disorder of nutrient partitioning: The MONA LISA hypothesis (1991) J Nutr, 121, pp. 1146-1162; Fain, J.N., Garcija-Sainz, J.A., Adrenergic regulation of adipocyte metabolism (1983) J Lipid Res, 24, pp. 945-966; Knowler, W.C., Pettitt, D.J., Saad, M.F., Charles, M.A., Nelson, R.G., Howard, B.V., Obesity in the Pima Indians: Its magnitude and relationship with diabetes (1991) Am J Clin Nutr, 53, pp. 1543S-1551S; Snitker, S., Tataranni, P.A., Ravussin, E., Respiratory quotient is inversely associated with muscle sympathetic nerve activity (1998) J Clin Endocrinol Metab, 83, pp. 3977-3979; Bai, Y.M., Lin, C.C., Chen, J.Y., Lin, C.Y., Su, T.P., Chou, P., Association of initial antipsychotic response to clozapine and long-term weight gain (2006) Am J Psychiatry, 163, pp. 1276-1279; Procyshyn, R.M., Wasan, K.M., Thornton, A.E., Barr, A.M., Chen, E.Y., Pomarol-Clotet, E., Changes in serum lipids, independent of weight, are associated with changes in symptoms during long-term clozapine treatment (2007) J Psychiatry Neurosci, 32, pp. 331-338; Nonogaki, K., New insights into sympathetic regulation of glucose and fat metabolism (2000) Diabetologia, 43, pp. 533-549; Piascik, M.T., Perez, D.M., Alpha1-adrenergic receptors: New insights and directions (2001) J Pharmacol Exp Ther, 298, pp. 403-410; Phares, D.A., Halverstadt, A.A., Shuldiner, A.R., Ferrell, R.E., Douglass, L.W., Ryan, A.S., Association between body fat response to exercise training and multilocus ADR genotypes (2004) Obes Res, 12, pp. 807-815; Dionne, I.J., Turner, A.N., Tchernof, A., Pollin, T.I., Avrithi, D., Gray, D., Identification of an interactive effect of beta3-and alpha2b-adreno- ceptor gene polymorphisms on fat mass in Caucasian women (2001) Diabetes, 50, pp. 91-95; Linne, Y., Dahlman, I., Hoffstedt, J., Beta1-adrenoceptor gene polymorphism predicts long-term changes in body weight (2005) Int J Obes Relat Metab Disord, 29, pp. 458-462; Dionne, I.J., Garant, M.J., Nolan, A.A., Pollin, T.I., Lewis, D.G., Shuldiner, A.R., Association between obesity and a polymorphism in the beta(1)-adrenoceptor gene (Gly389Arg ADRB1) in Caucasian women (2002) Int J Obes Relat Metab Disord, 26, pp. 633-639; Lin, R.C.Y., Ericsson, J.O., Benjafield, A.V., Morris, B.J., Association of beta2-adrenoceptor Gln27Glu variant with body weight but not hypertension (2001) Am J Hypertens, 14, pp. 1201-1204; Pereira, A.C., Floriano, M.S., Mota, G.F., Cunha, R.S., Herkenhoff, F.L., Mill, J.G., Beta2 adrenoceptor functional gene variants, obesity, and blood pressure level interactions in the general population (2003) Hypertension, 42, pp. 685-692; Ehrenborg, E., Skogsberg, J., Ruotolo, G., Large, V., Eriksson, P., Arner, P., The Q/E27 polymorphism in the beta2-adrenoceptor gene is associated with increased body weight and dyslipoproteinaemia involving trigly-ceride-rich lipoproteins (2000) J Intern Med, 247, pp. 651-656; Martinez, J.A., Corbalan, M.S., Sanchez-Villegas, A., Forga, L., Marti, A., Martinez-Gonzalez, M.A., Obesity risk is associated with carbohydrate intake in women carrying the Gln27Glu beta2-adrenoceptor polymorphism (2003) J Nutr, 133, pp. 2549-2554; MacHo-Azcarate, T., Marti, A., Calabuig, J., Martinez, J.A., Basal fat oxidation and after a peak oxygen consumption test in obese women with a beta2 adrenoceptor gene polymorphism (2003) J Nutr Biochem, 14, pp. 275-279; Meirhaeghe, A., Helbecque, N., Cottel, D., Amouyel, P., Impact of polymorphisms of the human beta2-adrenoceptor gene on obesity in a French population (2000) Int J Obes Relat Metab Disord, 24, pp. 382-387; Ukkola, O., Perusse, L., Chagnon, Y.C., Despres, J.-P., Bouchard, C., Interactions among the glucocorticoid receptor, lipoprotein lipase and adrenergic receptor genes and abdominal fat in the Québec Family Study (2001) International Journal of Obesity, 25 (9), pp. 1332-1339. , DOI 10.1038/sj.ijo.0801735; Gonzalez Sanchez, J.L., Proenza, A.M., Martinez Larrad, M.T., Ramis, J.M., Fernandez, P.C., Palou, A., The glutamine 27 glutamic acid polymorphism of the beta2-adrenoceptor gene is associated with abdominal obesity and greater risk of impaired glucose tolerance in men but not in women: A population-based study in Spain (2003) Clin Endocrinol (Oxf), 59, pp. 476-481; Ochoa, M.C., Marti, A., Azcona, C., Chueca, M., Oyarzabal, M., Pelach, R., Gene-gene interaction between PPAR gamma 2 and ADR beta 3 increases obesity risk in children and adolescents (2004) Int J Obes Relat Metab Disord, 28 (SUPPL. 3), pp. S37-S41; Xinli, W., Xiaomei, T., Meihua, P., Song, L., Association of a mutation in the beta3-adrenergic receptor gene with obesity and response to dietary intervention in Chinese children (2001) Acta Paediatr, 90, pp. 1233-1237; Baldessarini, R.J., Huston-Lyons, D., Campbell, A., Marsh, E., Cohen, B.M., Do central antiadrenergic actions contribute to the atypical properties of clozapine? (1992) Br J Psychiatry Suppl, 17, pp. 12-16; Clark, D.A., Arranz, M.J., Mata, I., Lopez-Ilundain, J., Perez-Nievas, F., Kerwin, R.W., Polymorphisms in the promoter region of the alpha1A-adrenoceptor gene are associated with schizophrenia/schizoaffective disorder in a Spanish isolate population (2005) Biol Psychiatry, 58, pp. 435-439; Huang, K., Shi, Y., Tang, W., Tang, R., Guo, S., Xu, Y., Meng, J., He, L., No association found between the promoter variants of ADRA1A and schizophrenia in the Chinese population (2008) Journal of Psychiatric Research, 42 (5), pp. 384-388. , DOI 10.1016/j.jpsychires.2007.02.008, PII S0022395607000301; Basile, V.S., Masellis, M., McIntyre, R.S., Meltzer, H.Y., Lieberman, J.A., Kennedy, J.L., Genetic dissection of atypical antipsychotic-induced weight gain: Novel preliminary data on the pharmacogenetic puzzle (2001) J Clin Psychiatry, 62 (SUPPL. 23), pp. 45-66; Ujike, H., Nomura, A., Morita, Y., Morio, A., Okahisa, Y., Kotaka, T., Multiple genetic factors in olanzapine-induced weight gain in schizophrenia patients: A cohort study (2008) J Clin Psychiatry, 69, pp. 1416-1422; Okajima, Y., Togo, M., Kitagawa, G., Nishikawa, S., Time series analysis of monthly body weight and blood pressures of one man from 29-65 years (2000) Am J Human Biol, 12, pp. 526-541; Simondon, K.B., Ndiaye, T., Dia, M., Yam, A., Ndiaye, M., Marra, A., Seasonal variations and trends in weight and arm circumference of non-pregnant rural Senegalese women, 1990-1997 (2008) Eur J Clin Nutr, 62, pp. 997-1004; Yang, M., Leung, S.S., Weight and length growth of two Chinese infant groups and the seasonal effects on their growth (1994) Ann Hum Biol, 21, pp. 547-562; Lei, B., Morris, D.P., Smith, M.P., Svetkey, L.P., Newman, M.F., Rotter, J.I., Novel human alpha1a-adrenoceptor single nucleotide polymorphisms alter receptor pharmacology and biological function (2005) Naunyn Schmiede-bergs Arch Pharmacol, 371, pp. 229-239; Razik, M.A., Lee, K., Price, R.R., Williams, M.R., Ongjoco, R.R., Dole, M.K., Transcriptional regulation of the human alpha1a-adrenergic receptor gene. Characterization of the 5'-regulatory and promoter region (1997) J Biol Chem, 272, pp. 28237-28246; Tebbutt, S.J., Genotyping of single nucleotide polymorphisms by arrayed primer extension (2007) Methods Mol Biol, 382, pp. 149-161; Pan, W.H., Yeh, W.T., How to define obesity? Evidence-based multiple action points for public awareness, screening, and treatment: An extension of Asian-Pacific recommendations (2008) Asia Pac J Clin Nutr, 17, pp. 370-374; Tadger, S., Melamed, Y., Weight gain due to long term antipsycho-tic treatment of persistent mental disorders (2008) Psychiatr Danub, 20, pp. 37-41; Shibata, K., Hirasawa, A., Moriyama, N., Kawabe, K., Ogawa, S., Tsujimoto, G., Alpha 1a-adrenoceptor polymorphism: Pharmacological characterization and association with benign prostatic hypertrophy (1996) Br J Pharmacol, 118, pp. 1403-1408; Bolonna, A.A., Arranz, M.J., Munro, J., Osborne, S., Petouni, M., Martinez, M., No influence of adrenergic receptor polymorphisms on schizophrenia and antipsychotic response (2000) Neurosci Lett, 280, pp. 65-68; Woodcock, E.A., Wang, B.H., Arthur, J.F., Lennard, A., Matkovich, S.J., Du, X.J., Inositol polyphosphate 1-phosphatase is a novel antihypertrophic factor (2002) J Biol Chem, 277, pp. 22734-22742; Clark, D.A., Mancama, D., Kerwin, R.W., Arranz, M.J., Expression of the alpha1A-adrenergic receptor in schizophrenia (2006) Neurosci Lett, 401, pp. 248-251; Li, L.M., Lei, S.F., Chen, X.D., Deng, F.Y., Tan, L.J., Zhu, X.Z., Anthropometric indices as the predictors of trunk obesity in Chinese young adults: Receiver operating characteristic analyses (2008) Ann Hum Biol, 35, pp. 342-348; Lee, C.M., Huxley, R.R., Wildman, R.P., Woodward, M., Indices of abdominal obesity are better discriminators of cardiovascular risk factors than BMI: A meta-analysis (2008) J Clin Epidemiol, 61, pp. 646-653; Romero, R., Bonet, J., De La Sierra, A., Aguilera, M.T., Undiagnosed obesity in hypertension: Clinical and therapeutic implications (2007) Blood Press, 16, pp. 347-353; Buckley, N.A., Sanders, P., Cardiovascular adverse effects of antipsychotic drugs (2000) Drug Saf, 23, pp. 215-228; Nourian, Z., Mow, T., Muftic, D., Burek, S., Pedersen, M.L., Matz, J., Orthostatic hypotensive effect of antipsychotic drugs in Wistar rats by in vivo and in vitro studies of alpha1-adrenoceptor function (2008) Psychophar-macology (Berl), 199, pp. 15-27; Richelson, E., Souder, T., Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds (2000) Life Sci, 68, pp. 29-39; Sramek, J.J., MacK, R.J., Awni, W., Hourani, J., Jhee, S.S., Barto, S., Two rapid-dose titrations of sertindole in patients with schizophrenia (1997) J Clin Psychopharmacol, 17, pp. 419-422; Barnes, T.R., McPhillips, M.A., Critical analysis and comparison of the side-effect and safety profiles of the new antipsychotics (1999) Br J Psychiatry Suppl, 38, pp. 34-43; Gu, D., Ge, D., Snieder, H., He, J., Chen, S., Huang, J., Association of alpha1A adrenergic receptor gene variants on chromosome 8p21 with human stage 2 hypertension (2006) J Hypertens, 24, pp. 1049-1056; Landsberg, L., Young, J.B., Catecholamines and the adrenal medulla (1992) Williams Textbook of Endocrinology, pp. 621-706. , Wilson JD, Foster DW, Kronenberg HM, Larsen PR (eds) 9th edn Saunders: Philadelphia; Zahorska-Markiewicz, B., Kucio, C., Piskorska, D., Adrenergic control of lipolysis and metabolic responses in obesity (1986) Horm Metab Res, 18, pp. 693-697; Defronzo, R.A., Thorin, D., Felber, J.P., Simonson, D.C., Jequier, T.D., Effect of beta and alpha adrenergic blockade on glucose-induced thermogenesis in man (1984) J Clin Invest, 73, pp. 633-639; Faintrenie, G., Geloen, A., Alpha-1 adrenergic stimulation of glucose uptake in rat white adipocytes (1998) J Pharmacol Exp Ther, 286, pp. 607-610; Boschmann, M., Krupp, G., Luft, F.C., Klaus, S., Jordan, J., In vivo response to α1-adrenoreceptor stimulation in human white adipose tissue (2002) Obesity Research, 10 (6), pp. 555-558; Flechtner-Mors, M., Jenkinson, C.P., Alt, A., Adler, G., Ditschuneit, H.H., In vivo alpha(1)-adrenergic lipolytic activity in subcutaneous adipose tissue of obese subjects (2002) J Pharmacol Exp Ther, 301, pp. 229-233
PY - 2010
Y1 - 2010
N2 - Noradrenaline and adrenaline are neurotransmitters of the sympathetic nervous system that interact with various adrenergic receptor (ADR) subtypes, and this regulates the basal metabolic rate, thermogenesis and efficiency of energy utilization. We examined a possible role of the gene coding for ADRA1A receptor in weight gain in schizophrenia subjects exposed to antipsychotics. A total of 401 schizophrenia in-patients treated with antipsychotics for 2 years were recruited and a final 394 DNA samples were genotyped. Their body mass indexes (BMIs) were recorded for 12 months and parameterized to be correlated in regression. Among the 58 single-nucleotide polymorphisms (SNPs) genotyped, 44 valid SNPs, which had minor allele frequency 0.03, were analyzed in statistics. Linear regression model with age, gender, diabetes, use of typical antipsychotics and use of atypical antipsychotics as covariates, with or without gender interaction, showed evidence of associations between the ADRA1A gene and BMI. Most of the SNPs associated with BMI are located in the promoter and intron regions, and being female appeared to enhance the gene effect. Our study suggests that the ADRA1A gene is involved in weight gain among schizophrenia patients treated with antipsychotics. Further molecular dissection of the ADRA1A gene warrants better understanding on weight gain mechanisms in schizophrenia. © 2010 Nature Publishing Group All rights reserved.
AB - Noradrenaline and adrenaline are neurotransmitters of the sympathetic nervous system that interact with various adrenergic receptor (ADR) subtypes, and this regulates the basal metabolic rate, thermogenesis and efficiency of energy utilization. We examined a possible role of the gene coding for ADRA1A receptor in weight gain in schizophrenia subjects exposed to antipsychotics. A total of 401 schizophrenia in-patients treated with antipsychotics for 2 years were recruited and a final 394 DNA samples were genotyped. Their body mass indexes (BMIs) were recorded for 12 months and parameterized to be correlated in regression. Among the 58 single-nucleotide polymorphisms (SNPs) genotyped, 44 valid SNPs, which had minor allele frequency 0.03, were analyzed in statistics. Linear regression model with age, gender, diabetes, use of typical antipsychotics and use of atypical antipsychotics as covariates, with or without gender interaction, showed evidence of associations between the ADRA1A gene and BMI. Most of the SNPs associated with BMI are located in the promoter and intron regions, and being female appeared to enhance the gene effect. Our study suggests that the ADRA1A gene is involved in weight gain among schizophrenia patients treated with antipsychotics. Further molecular dissection of the ADRA1A gene warrants better understanding on weight gain mechanisms in schizophrenia. © 2010 Nature Publishing Group All rights reserved.
KW - ADR
KW - ADRA1A gene
KW - Antipsychotics
KW - BMI
KW - Obesity
KW - Schizophrenia
KW - alpha 1A adrenergic receptor
KW - atypical antipsychotic agent
KW - neuroleptic agent
KW - adult
KW - article
KW - body mass
KW - controlled study
KW - diabetes mellitus
KW - DNA determination
KW - female
KW - gene frequency
KW - gene interaction
KW - genetic association
KW - genotype
KW - human
KW - intron
KW - major clinical study
KW - male
KW - pharmacogenetics
KW - priority journal
KW - promoter region
KW - schizophrenia
KW - side effect
KW - single nucleotide polymorphism
KW - weight gain
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Antipsychotic Agents
KW - Base Sequence
KW - Body Mass Index
KW - Female
KW - Humans
KW - Linkage Disequilibrium
KW - Male
KW - Middle Aged
KW - Polymorphism, Single Nucleotide
KW - Prospective Studies
KW - Receptors, Adrenergic, alpha-1
KW - Weight Gain
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UR - https://www.scopus.com/results/citedbyresults.uri?sort=plf-f&cite=2-s2.0-75549092068&src=s&imp=t&sid=ebdd0811fe5e96e4b5afac9055139f5c&sot=cite&sdt=a&sl=0&origin=recordpage&editSaveSearch=&txGid=d924ec2f08638a976169fe5a12a84bc3
U2 - 10.1038/tpj.2009.55
DO - 10.1038/tpj.2009.55
M3 - Article
SN - 1470-269X
VL - 10
SP - 30
EP - 39
JO - Pharmacogenomics Journal
JF - Pharmacogenomics Journal
IS - 1
ER -