Adipose-derived stem cells promote tumor initiation and accelerate tumor growth by interleukin-6 production

Hong Jian Wei; Rong Zeng; Jui Hua Lu; Wen-FuThomas Lai; Wei Hong Chen; Hen Yu Liu; Ya Ting Chang; Win Ping Deng

doi:10.18632/oncotarget.3481

Adipose-derived stem cells promote tumor initiation and accelerate tumor growth by interleukin-6 production

Hong Jian Wei, Rong Zeng, Jui Hua Lu, Wen-FuThomas Lai, Wei Hong Chen, Hen Yu Liu, Ya Ting Chang, Win Ping Deng

Research output: Contribution to journal › Article › peer-review

72 Citations (Scopus)

Abstract

Adipose-derived stem cells (ADSCs) are multipotent cells that have attracted much recent attention. Here, we show that ADSCs enhance sphere formation and in vivo tumor initiation of breast and colon cancer cells. In co-culture, ADSCs induced several stem cell markers in cancer cells. ADSCs also accelerated tumor growth. Interaction of ADSCs and cancer cells stimulated secretion of interlukin-6 in ADSCs, which in turn acted in a paracrine manner on cancer cells to enhance their malignant properties. Interleukin-6 regulated stem cell-related genes and activated JAK2/STAT3 in cancer cells. We suggest that ADSCs may enhance tumor initiation and promotion.

Original language	English
Pages (from-to)	7713-7726
Number of pages	14
Journal	Oncotarget
Volume	6
Issue number	10
DOIs	https://doi.org/10.18632/oncotarget.3481
Publication status	Published - 2015

Keywords

Adipose-derived stem cells
Breast cancer
Cancer stem cell
Colon cancer
Tumor initiation

ASJC Scopus subject areas

Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.18632/oncotarget.3481

Cite this

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abstract = "Adipose-derived stem cells (ADSCs) are multipotent cells that have attracted much recent attention. Here, we show that ADSCs enhance sphere formation and in vivo tumor initiation of breast and colon cancer cells. In co-culture, ADSCs induced several stem cell markers in cancer cells. ADSCs also accelerated tumor growth. Interaction of ADSCs and cancer cells stimulated secretion of interlukin-6 in ADSCs, which in turn acted in a paracrine manner on cancer cells to enhance their malignant properties. Interleukin-6 regulated stem cell-related genes and activated JAK2/STAT3 in cancer cells. We suggest that ADSCs may enhance tumor initiation and promotion.",

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AU - Wei, Hong Jian

AU - Zeng, Rong

AU - Lu, Jui Hua

AU - Lai, Wen-FuThomas

AU - Chen, Wei Hong

AU - Liu, Hen Yu

AU - Chang, Ya Ting

AU - Deng, Win Ping

PY - 2015

Y1 - 2015

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AB - Adipose-derived stem cells (ADSCs) are multipotent cells that have attracted much recent attention. Here, we show that ADSCs enhance sphere formation and in vivo tumor initiation of breast and colon cancer cells. In co-culture, ADSCs induced several stem cell markers in cancer cells. ADSCs also accelerated tumor growth. Interaction of ADSCs and cancer cells stimulated secretion of interlukin-6 in ADSCs, which in turn acted in a paracrine manner on cancer cells to enhance their malignant properties. Interleukin-6 regulated stem cell-related genes and activated JAK2/STAT3 in cancer cells. We suggest that ADSCs may enhance tumor initiation and promotion.

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Adipose-derived stem cells promote tumor initiation and accelerate tumor growth by interleukin-6 production

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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