Adenocarcinoma combined with malignant peripheral nerve sheath tumor of the gallbladder

Bao Chiien Chang, Tang Yi Tsao, Tsiu Ming Hwu, Jui Kai Cheng, Wei Hwa Lee

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3 Citations (Scopus)


Adenocarcinoma of the gallbladder combined with a malignant peripheral nerve sheath tumor (MPNST) in the gallbladder in an 81-year-old woman is reported. The resected gallbladder showed two distinct tumor components, the epithelioid type of MPNST and adenocarcinoma with areas of mucin production. Although the immediate postoperative course was uneventful, a pathologic fracture of her right upper femur developed 4 months after the cholecystectomy. The pathology was determined to be a feature of metastatic MPNST rather than of adenocarcinoma. A whole body bone scan revealed multiple metastases, including the left parietal skull, left ninth rib, seventh thoracic vertebra, and right upper third of the femur. Despite cholecystectomy and postoperative irradiation therapy, she died 6 months after diagnosis of the tumor. Without an autopsy the primary site of the MPNST was unknown. We found that the prognosis was very poor in patients with distal metastatic MPNST, especially in older patients.

Original languageEnglish
Pages (from-to)545-548
Number of pages4
JournalJournal of the Formosan Medical Association = Taiwan yi zhi
Issue number7
Publication statusPublished - Jul 1997
Externally publishedYes


  • adenocarcinoma
  • gallbladder neoplasm
  • malignant peripheral nerve sheath tumor

ASJC Scopus subject areas

  • Medicine(all)


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