Additional antitumor ecteinascidins from a Caribbean tunicate: Crystal structures and activities in vivo

Ryuichi Sakai; Kenneth L. Rinehart; Yue Guan; Andrew H.J. Wang

Additional antitumor ecteinascidins from a Caribbean tunicate: Crystal structures and activities in vivo

Ryuichi Sakai
, Kenneth L. Rinehart
, Yue Guan
, Andrew H.J. Wang

Research output: Contribution to journal › Article › peer-review

Abstract

Ecteinascidins (Ets), isolated from the Caribbean tunicate Ecteinascidia turbinata, protect mice in vivo against P388 lymphoma, B16 melanoma, M5076 ovarian sarcoma, Lewis lung carcinoma, and the LX-1 human lung and MX-1 human mammary carcinoma xenografts. Crystal structures of two tris(tetrahydroisoquinoline) Ets were investigated with single crystals of the 21-O-methyl-N¹²-formyl derivative of Et 729 and the natural N¹²-oxide of Et 743. Representatives of an additional class of Ets, Et 722 and Et 736, isolated from the same organism, were assigned tetrahydro-β-carboline-substituted bis(tetrahydroisoquinoline) structures by NMR and fast atom bombardment MS spectra.

Original language	English
Pages (from-to)	11456-11460
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	89
Issue number	23
Publication status	Published - Dec 1 1992
Externally published	Yes

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title = "Additional antitumor ecteinascidins from a Caribbean tunicate: Crystal structures and activities in vivo",

abstract = "Ecteinascidins (Ets), isolated from the Caribbean tunicate Ecteinascidia turbinata, protect mice in vivo against P388 lymphoma, B16 melanoma, M5076 ovarian sarcoma, Lewis lung carcinoma, and the LX-1 human lung and MX-1 human mammary carcinoma xenografts. Crystal structures of two tris(tetrahydroisoquinoline) Ets were investigated with single crystals of the 21-O-methyl-N12-formyl derivative of Et 729 and the natural N12-oxide of Et 743. Representatives of an additional class of Ets, Et 722 and Et 736, isolated from the same organism, were assigned tetrahydro-β-carboline-substituted bis(tetrahydroisoquinoline) structures by NMR and fast atom bombardment MS spectra.",

author = "Ryuichi Sakai and Rinehart, \{Kenneth L.\} and Yue Guan and Wang, \{Andrew H.J.\}",

year = "1992",

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journal = "Proceedings of the National Academy of Sciences of the United States of America",

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T1 - Additional antitumor ecteinascidins from a Caribbean tunicate

T2 - Crystal structures and activities in vivo

AU - Sakai, Ryuichi

AU - Rinehart, Kenneth L.

AU - Guan, Yue

AU - Wang, Andrew H.J.

PY - 1992/12/1

Y1 - 1992/12/1

N2 - Ecteinascidins (Ets), isolated from the Caribbean tunicate Ecteinascidia turbinata, protect mice in vivo against P388 lymphoma, B16 melanoma, M5076 ovarian sarcoma, Lewis lung carcinoma, and the LX-1 human lung and MX-1 human mammary carcinoma xenografts. Crystal structures of two tris(tetrahydroisoquinoline) Ets were investigated with single crystals of the 21-O-methyl-N12-formyl derivative of Et 729 and the natural N12-oxide of Et 743. Representatives of an additional class of Ets, Et 722 and Et 736, isolated from the same organism, were assigned tetrahydro-β-carboline-substituted bis(tetrahydroisoquinoline) structures by NMR and fast atom bombardment MS spectra.

AB - Ecteinascidins (Ets), isolated from the Caribbean tunicate Ecteinascidia turbinata, protect mice in vivo against P388 lymphoma, B16 melanoma, M5076 ovarian sarcoma, Lewis lung carcinoma, and the LX-1 human lung and MX-1 human mammary carcinoma xenografts. Crystal structures of two tris(tetrahydroisoquinoline) Ets were investigated with single crystals of the 21-O-methyl-N12-formyl derivative of Et 729 and the natural N12-oxide of Et 743. Representatives of an additional class of Ets, Et 722 and Et 736, isolated from the same organism, were assigned tetrahydro-β-carboline-substituted bis(tetrahydroisoquinoline) structures by NMR and fast atom bombardment MS spectra.

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M3 - Article

C2 - 1454834

AN - SCOPUS:0026474576

SN - 0027-8424

VL - 89

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JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 23

ER -

Additional antitumor ecteinascidins from a Caribbean tunicate: Crystal structures and activities in vivo

Abstract

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