TY - JOUR
T1 - Additional antitumor ecteinascidins from a Caribbean tunicate
T2 - Crystal structures and activities in vivo
AU - Sakai, R.
AU - Rinehart, K. L.
AU - Guan, Y.
AU - Wang, A. H.J.
PY - 1992
Y1 - 1992
N2 - Ecteinascidins (Ets), isolated from the Caribbean tunicate Ecteinascidia turbinata, protect mice in vivo against P388 lymphoma, B16 melanoma, M5076 ovarian sarcoma, Lewis lung carcinoma, and the LX-1 human lung and MX-1 human mammary carcinoma xenografts. Crystal structures of two tris(tetrahydroisoquinoline) Ets were investigated with single crystals of the 21-O-methyl-N12-formyl derivative of Et 729 and the natural N12-oxide of Et 743. Representatives of an additional class of Ets, Et 722 and Et 736, isolated from the same organism, were assigned tetrahydro-β-carboline- substituted bis(tetrahydroisoquinoline) structures by NMR and fast atom bombardment MS spectra.
AB - Ecteinascidins (Ets), isolated from the Caribbean tunicate Ecteinascidia turbinata, protect mice in vivo against P388 lymphoma, B16 melanoma, M5076 ovarian sarcoma, Lewis lung carcinoma, and the LX-1 human lung and MX-1 human mammary carcinoma xenografts. Crystal structures of two tris(tetrahydroisoquinoline) Ets were investigated with single crystals of the 21-O-methyl-N12-formyl derivative of Et 729 and the natural N12-oxide of Et 743. Representatives of an additional class of Ets, Et 722 and Et 736, isolated from the same organism, were assigned tetrahydro-β-carboline- substituted bis(tetrahydroisoquinoline) structures by NMR and fast atom bombardment MS spectra.
UR - http://www.scopus.com/inward/record.url?scp=0026474576&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026474576&partnerID=8YFLogxK
U2 - 10.1073/pnas.89.23.11456
DO - 10.1073/pnas.89.23.11456
M3 - Article
C2 - 1454834
AN - SCOPUS:0026474576
SN - 0027-8424
VL - 89
SP - 11456
EP - 11460
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 23
ER -