Acute ST-elevation myocardial infarction in young patients: 15 Years of experience in a single center

Su Kiat Chua, Huei Fong Hung, Kou Gi Shyu, Jun Jack Cheng, Ng Zuan Chiu, Che Ming Chang, Sheng Chang Lin, Jer Young Liou, Huey Ming Lo, Peiliang Kuan, Shih Huang Lee

Research output: Contribution to journalArticlepeer-review

53 Citations (Scopus)


Background: There have been few studies done regarding young patients with ST-elevation myocardial infarction (STEMI). The purpose of this study was to investigate the clinical characteristics and coronary angiographic features in young patientswith STEMI. Methods: We collected data on 849 consecutive patients with STEMI from 1992 to 2006. Baseline clinical characteristics, coronary anatomy, and outcome were compared in young (≤45 yrs) and older patients (>45 yrs). Results: Young patients presented 11.6% of all patients with STEMI. These patients were predominantly male (92.9% vs 80.3%, P <0.001), more likely to smoke (75.8% vs 47.2%, P <0.001), obese (48.2% vs 27.9%, P = 0.002), have higher triglyceride levels (176.9± 153.8 mg/dL vs 140.7± 112.7mg/dL, P = 0.005), and lower high-density lipoprotein cholesterol (37.1 ± 7.9mg/dL vs 42.8 ± 14.3mg/dL, P = 0.005) than older patients. Also, younger patients had a shorter hospital stay (7.1 ± 4.9 d vs 8.5 ± 6.7 d, P = 0.04), less in-hospital morbidity (29.3% vs 39.7%, P = 0.02), and mortality (3.0% vs 12.3%, P = 0.002). Killip class III or IV could predict in-hospital morbidity and mortality in young patients. Both groups had similar rates of repeated percutaneous coronary intervention (PCI; 45.5% vs 41.5%, P = 0.23) and reinfarction (6.1% vs 3.2%, P = 0.32). Mortality rate during follow-up was significantly lower in younger patients (3.0% vs 19.6%, P <0.001). Conclusion: Cigarette smoking, obesity, and dyslipidemia were the most important modifiable risk factors in young patients with STEMI. These patients had a better outcome than older patients without differences in repeated PCI and reinfarction between them. Only Killip class III or IV could predict in-hospitalmorbidity and mortality in young patients with STEMI.

Original languageEnglish
Pages (from-to)140-148
Number of pages9
JournalClinical Cardiology
Issue number3
Publication statusPublished - Mar 2010

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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