Acute sciatica: An unusual presentation of extramedullar relapse of acute lymphoblastic leukemia

Hao Chuan Liu, Giun Yi Hung, Hsiu Ju Yen, Ming Yun Hsieh, Tzeon Jye Chiou

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


A 10-year-old boy who had been treated for acute lymphoblastic leukemia presented with persistent numbness of the left big toe and progressive pain of the ipsilateral lower leg. He had received allogeneic bone marrow transplantation 3 months after a testicular relapse. He was in hematologic remission at admission but as progressive swelling of his left leg continued, bone marrow relapse developed. A muscle biopsy revealed leukemic infiltrates in the surrounding muscles of the left sciatic nerve, and swelling of the nerve was found on a magnetic resonance imaging scan. His symptoms/signs subsided soon after reinduction chemotherapy. Unfortunately, he didn't survive because of a fungal sepsis that developed during the neutropenic state. This case represents a rare neurologic complication of what is currently an uncommon presentation for relapse of acute lymphoblastic leukemia, with acute sciatica and without coexisting epidural or leptomeningeal leukemia.

Original languageEnglish
Pages (from-to)163-165
Number of pages3
JournalInternational Journal of Hematology
Issue number2
Publication statusPublished - Aug 2007
Externally publishedYes


  • Acute lymphoblastic leukemia
  • Acute sciatica
  • Extramedullary relapse
  • Leukemic relapse

ASJC Scopus subject areas

  • Hematology


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