Acute respiratory distress syndrome following intrathecal methotrexate administration: A case report and review of literature

M. S. Dai; C. L. Ho; Y. C. Chen; W. Y. Kao; T. Y. Chao

doi:10.1007/s002770000217

Acute respiratory distress syndrome following intrathecal methotrexate administration: A case report and review of literature

M. S. Dai, C. L. Ho, Y. C. Chen, W. Y. Kao, T. Y. Chao

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Acute Respiratory distress syndrome (ARDS) is a rare complication following intrathecal (IT) injection of methotrexate (MTX) in adult acute lymphoblastic leukemia (ALL) patients. A 19-year-old man with ALL developed strikingly acute respiratory failure during central nervous system (CNS) prophylaxis with IT MTX administration and cranial irradiation. Histopathologic study of the lungs revealed a pattern of diffuse alveolar damage with interstitial cellular infiltration. His symptoms were relieved soon following treatment with corticosteroids and the pulmonary infiltrates resolved gradually. Pulmonary symptoms did not recur as he was continuously treated with oral corticosteroids.

Original language	English
Pages (from-to)	696-699
Number of pages	4
Journal	Annals of Hematology
Volume	79
Issue number	12
DOIs	https://doi.org/10.1007/s002770000217
Publication status	Published - 2000
Externally published	Yes

Keywords

Acute respiratory distress syndrome
Intrathecal
Methotrexate

ASJC Scopus subject areas

Hematology

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10.1007/s002770000217

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abstract = "Acute Respiratory distress syndrome (ARDS) is a rare complication following intrathecal (IT) injection of methotrexate (MTX) in adult acute lymphoblastic leukemia (ALL) patients. A 19-year-old man with ALL developed strikingly acute respiratory failure during central nervous system (CNS) prophylaxis with IT MTX administration and cranial irradiation. Histopathologic study of the lungs revealed a pattern of diffuse alveolar damage with interstitial cellular infiltration. His symptoms were relieved soon following treatment with corticosteroids and the pulmonary infiltrates resolved gradually. Pulmonary symptoms did not recur as he was continuously treated with oral corticosteroids.",

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T1 - Acute respiratory distress syndrome following intrathecal methotrexate administration

T2 - A case report and review of literature

AU - Dai, M. S.

AU - Ho, C. L.

AU - Chen, Y. C.

AU - Kao, W. Y.

AU - Chao, T. Y.

PY - 2000

Y1 - 2000

N2 - Acute Respiratory distress syndrome (ARDS) is a rare complication following intrathecal (IT) injection of methotrexate (MTX) in adult acute lymphoblastic leukemia (ALL) patients. A 19-year-old man with ALL developed strikingly acute respiratory failure during central nervous system (CNS) prophylaxis with IT MTX administration and cranial irradiation. Histopathologic study of the lungs revealed a pattern of diffuse alveolar damage with interstitial cellular infiltration. His symptoms were relieved soon following treatment with corticosteroids and the pulmonary infiltrates resolved gradually. Pulmonary symptoms did not recur as he was continuously treated with oral corticosteroids.

AB - Acute Respiratory distress syndrome (ARDS) is a rare complication following intrathecal (IT) injection of methotrexate (MTX) in adult acute lymphoblastic leukemia (ALL) patients. A 19-year-old man with ALL developed strikingly acute respiratory failure during central nervous system (CNS) prophylaxis with IT MTX administration and cranial irradiation. Histopathologic study of the lungs revealed a pattern of diffuse alveolar damage with interstitial cellular infiltration. His symptoms were relieved soon following treatment with corticosteroids and the pulmonary infiltrates resolved gradually. Pulmonary symptoms did not recur as he was continuously treated with oral corticosteroids.

KW - Acute respiratory distress syndrome

KW - Intrathecal

KW - Methotrexate

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JO - Annals of Hematology

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ER -

Acute respiratory distress syndrome following intrathecal methotrexate administration: A case report and review of literature

Abstract

Keywords

ASJC Scopus subject areas

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