Acute invasive fungal rhinosinusitis in post-COVID-19 patients in Vietnam

Ly Xuan Quang, Truong Thanh Tam, Luong Huu Dang, Yen Chun Chen, Shih Han Hung, Tran Thanh Tai, Nguyen Le Vu Hoang, Nguyen Van Thanh

Research output: Contribution to journalArticlepeer-review


Background: Acute invasive fungal rhinosinusitis (AIFR) is a potentially lethal infection commonly found in immunocompromised patients. It is considered the most aggressive subtype of fungal sinusitis and can lead to severe morbidity and mortality. There was a significant increase in the incidence of AIFR in post-COVID-19 patients compared to AIFR cases before the COVID-19 pandemic. This study aimed to describe the clinical presentation of AIFR associated with COVID-19 illness. Methods: A retrospective study included 22 patients diagnosed with AIFR with a recent COVID-19 infection. Results: The most frequent disease associated with AIFR was diabetes mellitus (95.5%). The mycological analysis identified infection caused by Aspergillus species in 72.7% of patients. Along with stabilizing hemodynamic parameters and controlling any comorbidities, all patients in the present study underwent combined surgical debridement followed by antifungal medications. The overall survival rate was 72.7%. The chance of developing a fatal outcome was significantly higher if meningitis presented initially (odds ratio 35.63, p < 0.05). Conclusion: The presence of meningitis upon initial diagnosis is related to a significantly higher chance of developing a fatal outcome and should be considered, especially in AIFR patients previously treated for COVID-19 infections. Early diagnosis, early use of antifungal agents, aggressive surgical debridement, and control of comorbid conditions remain crucial in managing AIFR. Level of evidence: 4.

Original languageEnglish
JournalJournal of the Formosan Medical Association
Publication statusAccepted/In press - 2023


  • Acute invasive fungal infection
  • COVID-19
  • Diabetes mellitus
  • Endoscopic debridement
  • Survival outcome

ASJC Scopus subject areas

  • Medicine(all)


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