Acute hematogenous osteomyelitis and septic arthritis in children

Hui Chin Kao, Yhu Chering Huang, Cheng Hsun Chiu, Luan Yin Chang, Zhon Liau Lee, Pei Wen Chung, Feng Chen Kao, Tzou Yien Lin

Research output: Contribution to journalArticlepeer-review

57 Citations (Scopus)


This retrospective study analyzed the clinical, bacteriological, and radiological features of pediatric patients with acute hematogenous osteomyelitis and septic arthritis. Eighty-four patients with septic arthritis and 39 with acute hematogenous osteomyelitis were enrolled. Their age ranged from 13 days to 17 years. In patients with septic arthritis, the hip joint was the most often infected site. The tibia was the most often involved site in acute hematogenous osteomyelitis. A bacteriological diagnosis was established in 78 (63%) patients. Overall, methicillin-susceptible Staphylococcus aureus (36 cases) was the most common causative organism identified, followed by methicillin-resistant S. aureus (10 cases). The median duration of antibiotic therapy was 33 days. Serum bactericidal titers were obtained for 19 (15%) of the 123 patients. The median duration of hospitalization and antibiotic treatment was not significantly different between patients with and without serum bactericidal titer testing. More patients without serum bactericidal titer testing had symptom relapse which required re-admission for further treatment. In conclusion, the incidence of methicillin-resistant S. aureus as a cause of bone and joint infections has been increasing. Serum bactericidal titer is valuable for the management of patients receiving sequential therapy for acute hematogenous osteomyelitis and septic arthritis.

Original languageEnglish
Pages (from-to)260-265
Number of pages6
JournalJournal of Microbiology, Immunology and Infection
Issue number4
Publication statusPublished - Dec 2003
Externally publishedYes


  • Osteomyelitis
  • Septic arthritis
  • Serum bactericidal titer

ASJC Scopus subject areas

  • Microbiology (medical)
  • Immunology and Allergy
  • Immunology and Microbiology(all)


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