Acute cholecystitis in end-stage renal disease patients: A nation-wide longitudinal study

Yung Tai Chen, Shuo Ming Ou, Pei Wen Chao, Szu Yuan Li, Tzeng Ji Chen, Lung Wen Tsai, Tzen Wen Chen

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Background: The objective of this study was to evaluate the risks of acute cholecystitis among end-stage renal disease patients and compare the incidence between two dialysis modality. Study design: In this retrospective cohort study, records of fifty thousand end-stage renal disease patients older than 20 years of age from 1998 to 2007 and an age, gender, Charlson's score, diabetes, and dyslipidemia matched control cohort were retrieved from Taiwan National Health Insurance Research Database. Hospitalizations for acute cholecystitis were retrieved using ICD-9-CM diagnosis codes and ICD-9-CM operation codes from in-patient claims. Results: The incidence rates were 5.8 per 1000 patient-years in the end-stage renal disease patients and 0.92 per 1000 patient-years in the control group. End-stage renal disease was an independent risk factor for acute cholecystitis. In the end-stage renal disease patients, independent risk factors were old age, higher Charlson's score, diabetes, severe liver disease, atrial fibrillation, and haemodialysis (all p<0.05). However, the peritoneal dialysis patients had a higher mortality rate after developing acute cholecystitis. Conclusion: Acute cholecystitis is not uncommon in end-stage renal disease patients. The independent risk factors were older age, higher Charlson's score, atrial fibrillation, severe liver disease, diabetes, and dialysis modality. Haemodialysis patients had a higher risk of acute cholecystitis than PD patients.

Original languageEnglish
Pages (from-to)142-146
Number of pages5
JournalDigestive and Liver Disease
Issue number2
Publication statusPublished - Feb 2013


  • Acute cholecystitis
  • End-stage renal disease
  • Renal replacement therapy

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology


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