Activation of topoisomerase II-mediated excision of chromosomal DNA loops during oxidative stress

Tsai Kun Li; Allen Y. Chen; Chiang Yu; Yong Mao; Huimin Wang; Leroy-Fong Liu

Activation of topoisomerase II-mediated excision of chromosomal DNA loops during oxidative stress

Tsai Kun Li, Allen Y. Chen, Chiang Yu, Yong Mao, Huimin Wang, Leroy-Fong Liu

Research output: Contribution to journal › Article › peer-review

Abstract

Hydrogen peroxide (H ₂O ₂), a reactive oxygen species (ROS), is known to induce oxidative stress and apoptosis. U937 cells treated with H ₂O ₂ were shown to produce high molecular weight (HMW) DNA fragments ~50 to 100 kb in size in

Original language	English
Pages (from-to)	1553-1560
Number of pages	8
Journal	Genes and Development
Volume	13
Issue number	12
Publication status	Published - Jun 15 1999
Externally published	Yes

Keywords

Apoptosis
H O
Oxidative stress
TOP2
VM-26

ASJC Scopus subject areas

Genetics
Developmental Biology

Cite this

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title = "Activation of topoisomerase II-mediated excision of chromosomal DNA loops during oxidative stress",

abstract = "Hydrogen peroxide (H 2O 2), a reactive oxygen species (ROS), is known to induce oxidative stress and apoptosis. U937 cells treated with H 2O 2 were shown to produce high molecular weight (HMW) DNA fragments ~50 to 100 kb in size in ",

keywords = "Apoptosis, H O, Oxidative stress, TOP2, VM-26",

author = "Li, {Tsai Kun} and Chen, {Allen Y.} and Chiang Yu and Yong Mao and Huimin Wang and Leroy-Fong Liu",

year = "1999",

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AU - Li, Tsai Kun

AU - Chen, Allen Y.

AU - Yu, Chiang

AU - Mao, Yong

AU - Wang, Huimin

AU - Liu, Leroy-Fong

PY - 1999/6/15

Y1 - 1999/6/15

N2 - Hydrogen peroxide (H 2O 2), a reactive oxygen species (ROS), is known to induce oxidative stress and apoptosis. U937 cells treated with H 2O 2 were shown to produce high molecular weight (HMW) DNA fragments ~50 to 100 kb in size in

AB - Hydrogen peroxide (H 2O 2), a reactive oxygen species (ROS), is known to induce oxidative stress and apoptosis. U937 cells treated with H 2O 2 were shown to produce high molecular weight (HMW) DNA fragments ~50 to 100 kb in size in

KW - Apoptosis

KW - H O

KW - Oxidative stress

KW - TOP2

KW - VM-26

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M3 - Article

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ER -

Activation of topoisomerase II-mediated excision of chromosomal DNA loops during oxidative stress

Abstract

Keywords

ASJC Scopus subject areas

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