Activation of muscarinic M-3 receptor may decrease glucose uptake and lipolysis in adipose tissue of rats

Ting Ting Yang; Cheng Kuei Chang; Chiung Wen Tsao; Ya Mei Hsu; Chao Tien Hsu; Juei Tang Cheng

doi:10.1016/j.neulet.2008.12.029

Activation of muscarinic M-3 receptor may decrease glucose uptake and lipolysis in adipose tissue of rats

Ting Ting Yang, Cheng Kuei Chang, Chiung Wen Tsao, Ya Mei Hsu, Chao Tien Hsu, Juei Tang Cheng

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Role of muscarinic receptor in the regulation of glucose uptake or lipolysis in adipose tissue remained unclear. In epididymal white adipose tissue (WAT) isolated from Wistar rats, we observed that acetylcholine (ACh) attenuated the insulin-stimulated glucose uptake and the release of glycerol from WAT in a concentration-dependent manner. Using the blockade of specific antagonists, both actions of ACh were characterized mainly due to an activation of M3 receptors. In the presence of various inhibitors for PLC-PKC pathway, ACh-decreased glucose uptake was also reversed. Taken together, these results suggest that muscarinic M3 receptor is involved in the regulation of glucose uptake and/or lipolysis in adipose tissue.

Original language	English
Pages (from-to)	57-59
Number of pages	3
Journal	Neuroscience Letters
Volume	451
Issue number	1
DOIs	https://doi.org/10.1016/j.neulet.2008.12.029
Publication status	Published - Feb 13 2009
Externally published	Yes

Keywords

Acetylcholine
Adipose
Glucose uptake
Lipolysis
Muscarinic receptor

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neulet.2008.12.029

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title = "Activation of muscarinic M-3 receptor may decrease glucose uptake and lipolysis in adipose tissue of rats",

abstract = "Role of muscarinic receptor in the regulation of glucose uptake or lipolysis in adipose tissue remained unclear. In epididymal white adipose tissue (WAT) isolated from Wistar rats, we observed that acetylcholine (ACh) attenuated the insulin-stimulated glucose uptake and the release of glycerol from WAT in a concentration-dependent manner. Using the blockade of specific antagonists, both actions of ACh were characterized mainly due to an activation of M3 receptors. In the presence of various inhibitors for PLC-PKC pathway, ACh-decreased glucose uptake was also reversed. Taken together, these results suggest that muscarinic M3 receptor is involved in the regulation of glucose uptake and/or lipolysis in adipose tissue.",

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author = "Yang, {Ting Ting} and Chang, {Cheng Kuei} and Tsao, {Chiung Wen} and Hsu, {Ya Mei} and Hsu, {Chao Tien} and Cheng, {Juei Tang}",

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AU - Yang, Ting Ting

AU - Chang, Cheng Kuei

AU - Tsao, Chiung Wen

AU - Hsu, Ya Mei

AU - Hsu, Chao Tien

AU - Cheng, Juei Tang

PY - 2009/2/13

Y1 - 2009/2/13

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AB - Role of muscarinic receptor in the regulation of glucose uptake or lipolysis in adipose tissue remained unclear. In epididymal white adipose tissue (WAT) isolated from Wistar rats, we observed that acetylcholine (ACh) attenuated the insulin-stimulated glucose uptake and the release of glycerol from WAT in a concentration-dependent manner. Using the blockade of specific antagonists, both actions of ACh were characterized mainly due to an activation of M3 receptors. In the presence of various inhibitors for PLC-PKC pathway, ACh-decreased glucose uptake was also reversed. Taken together, these results suggest that muscarinic M3 receptor is involved in the regulation of glucose uptake and/or lipolysis in adipose tissue.

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Activation of muscarinic M-3 receptor may decrease glucose uptake and lipolysis in adipose tissue of rats

Abstract

Keywords

ASJC Scopus subject areas

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