TY - JOUR
T1 - Activating transcription factor 3, an early cellular adaptive responder in ischemia/reperfusion-induced injury
AU - Lin, Heng
AU - Cheng, Ching Feng
N1 - Funding Information:
This work was supported by NSF under grants DMC-8657416 and DDM-8996238, and by the Savannah River Laboratory under contract AX-0721012.
Publisher Copyright:
© 2018 Tzu Chi Medical Journal | Published by Wolters Kluwer - Medknow
PY - 2018
Y1 - 2018
N2 - Recent studies have reported that ischemia/reperfusion (I/R) may act in the immune system where an exaggerated inflammatory response is initiated. With the activation of the immune system, damage-associated molecular patterns migrate and adhere to the I/R region, consequently inducing multiorgan injury. Emerging data indicate that upon I/R, stress-inducible proteins, including activating transcription factor 3 (ATF3), play essential roles in signaling during antiapoptotic, antimigration, and anti-inflammatory processes. Accumulating data suggest that ATF3 may be a potential target in I/R- or inflammation-induced organ dysfunction. This minireview focuses on the emerging evidence of the roles of ATF3 in multiple organs including the kidney, myocardium, and brain following I/R injury. In addition, this review addresses the role of ATF3 in chronic inflammation-induced pathophysiologies such as diabetes and atherosclerosis.
AB - Recent studies have reported that ischemia/reperfusion (I/R) may act in the immune system where an exaggerated inflammatory response is initiated. With the activation of the immune system, damage-associated molecular patterns migrate and adhere to the I/R region, consequently inducing multiorgan injury. Emerging data indicate that upon I/R, stress-inducible proteins, including activating transcription factor 3 (ATF3), play essential roles in signaling during antiapoptotic, antimigration, and anti-inflammatory processes. Accumulating data suggest that ATF3 may be a potential target in I/R- or inflammation-induced organ dysfunction. This minireview focuses on the emerging evidence of the roles of ATF3 in multiple organs including the kidney, myocardium, and brain following I/R injury. In addition, this review addresses the role of ATF3 in chronic inflammation-induced pathophysiologies such as diabetes and atherosclerosis.
KW - Activating transcription factor 3
KW - Ischemia
KW - Reperfusion
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U2 - 10.4103/tcmj.tcmj_37_18
DO - 10.4103/tcmj.tcmj_37_18
M3 - Review article
AN - SCOPUS:85054022926
SN - 1016-3190
VL - 30
SP - 61
EP - 65
JO - Tzu Chi Medical Journal
JF - Tzu Chi Medical Journal
IS - 2
ER -
