Action of Reverse T3 on Cancer Cells

Hung Yun Lin; Heng Yuan Tang; Matthew Leinung; Shaker A. Mousa; Aleck Hercbergs; Paul J. Davis

doi:10.1080/07435800.2019.1600536

Action of Reverse T3 on Cancer Cells

Hung Yun Lin, Heng Yuan Tang, Matthew Leinung, Shaker A. Mousa, Aleck Hercbergs, Paul J. Davis

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Background: Reverse T3 (rT3; 3,3',5'-triiodo-L-thyronine) is widely regarded as an inactive naturally occurring analog of thyroid hormone. rT3 is known to bind to the thyroid hormone analog receptor on plasma membrane integrin αvβ3. This integrin is generously expressed by tumor cells and is the initiation site for the stimulation by L-thyroxine (T4) at physiological free concentrations on cancer cell proliferation. Results: In the present studies, we show that rT3 caused increases of proliferation in vitro of 50% to 80% (P < 0.05–0.001) of human breast cancer and glioblastoma cells. Conclusion: rT3 may be a host factor supporting cancer growth.

Original language	English
Journal	Endocrine Research
DOIs	https://doi.org/10.1080/07435800.2019.1600536
Publication status	Published - Jan 1 2019

Keywords

3,3',5’-triiodo-L-thyronine
breast cancer
glioblastoma
Integrin αvβ3
L-thyroxine

ASJC Scopus subject areas

Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/07435800.2019.1600536

Cite this

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title = "Action of Reverse T3 on Cancer Cells",

abstract = "Background: Reverse T3 (rT3; 3,3',5'-triiodo-L-thyronine) is widely regarded as an inactive naturally occurring analog of thyroid hormone. rT3 is known to bind to the thyroid hormone analog receptor on plasma membrane integrin αvβ3. This integrin is generously expressed by tumor cells and is the initiation site for the stimulation by L-thyroxine (T4) at physiological free concentrations on cancer cell proliferation. Results: In the present studies, we show that rT3 caused increases of proliferation in vitro of 50% to 80% (P < 0.05–0.001) of human breast cancer and glioblastoma cells. Conclusion: rT3 may be a host factor supporting cancer growth.",

keywords = "3,3',5{\textquoteright}-triiodo-L-thyronine, breast cancer, glioblastoma, Integrin αvβ3, L-thyroxine",

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journal = "Endocrine Research",

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T1 - Action of Reverse T3 on Cancer Cells

AU - Lin, Hung Yun

AU - Tang, Heng Yuan

AU - Leinung, Matthew

AU - Mousa, Shaker A.

AU - Hercbergs, Aleck

AU - Davis, Paul J.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Reverse T3 (rT3; 3,3',5'-triiodo-L-thyronine) is widely regarded as an inactive naturally occurring analog of thyroid hormone. rT3 is known to bind to the thyroid hormone analog receptor on plasma membrane integrin αvβ3. This integrin is generously expressed by tumor cells and is the initiation site for the stimulation by L-thyroxine (T4) at physiological free concentrations on cancer cell proliferation. Results: In the present studies, we show that rT3 caused increases of proliferation in vitro of 50% to 80% (P < 0.05–0.001) of human breast cancer and glioblastoma cells. Conclusion: rT3 may be a host factor supporting cancer growth.

AB - Background: Reverse T3 (rT3; 3,3',5'-triiodo-L-thyronine) is widely regarded as an inactive naturally occurring analog of thyroid hormone. rT3 is known to bind to the thyroid hormone analog receptor on plasma membrane integrin αvβ3. This integrin is generously expressed by tumor cells and is the initiation site for the stimulation by L-thyroxine (T4) at physiological free concentrations on cancer cell proliferation. Results: In the present studies, we show that rT3 caused increases of proliferation in vitro of 50% to 80% (P < 0.05–0.001) of human breast cancer and glioblastoma cells. Conclusion: rT3 may be a host factor supporting cancer growth.

KW - 3,3',5’-triiodo-L-thyronine

KW - breast cancer

KW - glioblastoma

KW - Integrin αvβ3

KW - L-thyroxine

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JF - Endocrine Research

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Action of Reverse T3 on Cancer Cells

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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