Aconitamide, a novel alkaloid from the roots of Aconitum carmichaeli

Zong-Huei Li; Yu Chang Chen; Ching Kuo Lee; Hsun Shuo Chang; Ching Chuan Kuo; Che Yi Chao; Jing Jer Lin; Lee Chiang Lo; Yueh Hsiung Kuo

doi:10.1177/1934578x1300800637

Aconitamide, a novel alkaloid from the roots of Aconitum carmichaeli

Zong-Huei Li
, Yu Chang Chen
, Ching Kuo Lee
, Hsun Shuo Chang
, Ching Chuan Kuo
, Che Yi Chao
, Jing Jer Lin
, Lee Chiang Lo
, Yueh Hsiung Kuo

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Aconitum carmichaeli Debx. is a traditional Chinese medicine commonly employed for curing a wide array of diseases in East Asia. From the ethyl acetate soluble fraction of the methanolic extracts of A. carmichaeli, a new alkaloid, aconitamide (1), along with eighteen known compounds 2-19 were isolated by column chromatography and identified on the basis of spectroscopic analyses. The anti-telomerase activity of 1-19 was also assessed, but no activity was found, even at a concentration higher than 30 μM.

Original language	English
Pages (from-to)	827-828
Number of pages	2
Journal	Natural Product Communications
Volume	8
Issue number	6
DOIs	https://doi.org/10.1177/1934578x1300800637
Publication status	Published - Jun 2013

Keywords

Aconitamide
Aconitum carmichaeli Debx.
Anti-telomerase
Chinese herb
Ranunculaceae
Roots

ASJC Scopus subject areas

Pharmacology
Plant Science
Drug Discovery
Complementary and alternative medicine

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10.1177/1934578x1300800637

Cite this

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title = "Aconitamide, a novel alkaloid from the roots of Aconitum carmichaeli",

abstract = "Aconitum carmichaeli Debx. is a traditional Chinese medicine commonly employed for curing a wide array of diseases in East Asia. From the ethyl acetate soluble fraction of the methanolic extracts of A. carmichaeli, a new alkaloid, aconitamide (1), along with eighteen known compounds 2-19 were isolated by column chromatography and identified on the basis of spectroscopic analyses. The anti-telomerase activity of 1-19 was also assessed, but no activity was found, even at a concentration higher than 30 μM.",

keywords = "Aconitamide, Aconitum carmichaeli Debx., Anti-telomerase, Chinese herb, Ranunculaceae, Roots",

author = "Zong-Huei Li and Chen, \{Yu Chang\} and Lee, \{Ching Kuo\} and Chang, \{Hsun Shuo\} and Kuo, \{Ching Chuan\} and Chao, \{Che Yi\} and Lin, \{Jing Jer\} and Lo, \{Lee Chiang\} and Kuo, \{Yueh Hsiung\}",

year = "2013",

month = jun,

doi = "10.1177/1934578x1300800637",

language = "English",

volume = "8",

pages = "827--828",

journal = "Natural Product Communications",

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AU - Li, Zong-Huei

AU - Chen, Yu Chang

AU - Lee, Ching Kuo

AU - Chang, Hsun Shuo

AU - Kuo, Ching Chuan

AU - Chao, Che Yi

AU - Lin, Jing Jer

AU - Lo, Lee Chiang

AU - Kuo, Yueh Hsiung

PY - 2013/6

Y1 - 2013/6

N2 - Aconitum carmichaeli Debx. is a traditional Chinese medicine commonly employed for curing a wide array of diseases in East Asia. From the ethyl acetate soluble fraction of the methanolic extracts of A. carmichaeli, a new alkaloid, aconitamide (1), along with eighteen known compounds 2-19 were isolated by column chromatography and identified on the basis of spectroscopic analyses. The anti-telomerase activity of 1-19 was also assessed, but no activity was found, even at a concentration higher than 30 μM.

AB - Aconitum carmichaeli Debx. is a traditional Chinese medicine commonly employed for curing a wide array of diseases in East Asia. From the ethyl acetate soluble fraction of the methanolic extracts of A. carmichaeli, a new alkaloid, aconitamide (1), along with eighteen known compounds 2-19 were isolated by column chromatography and identified on the basis of spectroscopic analyses. The anti-telomerase activity of 1-19 was also assessed, but no activity was found, even at a concentration higher than 30 μM.

KW - Aconitamide

KW - Aconitum carmichaeli Debx.

KW - Anti-telomerase

KW - Chinese herb

KW - Ranunculaceae

KW - Roots

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DO - 10.1177/1934578x1300800637

M3 - Article

AN - SCOPUS:84886434523

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JO - Natural Product Communications

JF - Natural Product Communications

IS - 6

ER -

Aconitamide, a novel alkaloid from the roots of Aconitum carmichaeli

Abstract

Keywords

ASJC Scopus subject areas

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