Aconitamide, a novel alkaloid from the roots of Aconitum carmichaeli

Zong-Huei Li; Yu Chang Chen; Ching Kuo Lee; Hsun Shuo Chang; Ching Chuan Kuo; Che Yi Chao; Jing Jer Lin; Lee Chiang Lo; Yueh Hsiung Kuo

doi:10.1177/1934578x1300800637

Aconitamide, a novel alkaloid from the roots of Aconitum carmichaeli

Zong-Huei Li, Yu Chang Chen, Ching Kuo Lee, Hsun Shuo Chang, Ching Chuan Kuo, Che Yi Chao, Jing Jer Lin, Lee Chiang Lo, Yueh Hsiung Kuo

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Aconitum carmichaeli Debx. is a traditional Chinese medicine commonly employed for curing a wide array of diseases in East Asia. From the ethyl acetate soluble fraction of the methanolic extracts of A. carmichaeli, a new alkaloid, aconitamide (1), along with eighteen known compounds 2-19 were isolated by column chromatography and identified on the basis of spectroscopic analyses. The anti-telomerase activity of 1-19 was also assessed, but no activity was found, even at a concentration higher than 30 μM.

Original language	English
Pages (from-to)	827-828
Number of pages	2
Journal	Natural Product Communications
Volume	8
Issue number	6
DOIs	https://doi.org/10.1177/1934578x1300800637
Publication status	Published - Jun 2013

Keywords

Aconitamide
Aconitum carmichaeli Debx.
Anti-telomerase
Chinese herb
Ranunculaceae
Roots

ASJC Scopus subject areas

Drug Discovery
Complementary and alternative medicine
Plant Science
Pharmacology

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10.1177/1934578x1300800637

Cite this

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abstract = "Aconitum carmichaeli Debx. is a traditional Chinese medicine commonly employed for curing a wide array of diseases in East Asia. From the ethyl acetate soluble fraction of the methanolic extracts of A. carmichaeli, a new alkaloid, aconitamide (1), along with eighteen known compounds 2-19 were isolated by column chromatography and identified on the basis of spectroscopic analyses. The anti-telomerase activity of 1-19 was also assessed, but no activity was found, even at a concentration higher than 30 μM.",

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AU - Li, Zong-Huei

AU - Chen, Yu Chang

AU - Lee, Ching Kuo

AU - Chang, Hsun Shuo

AU - Kuo, Ching Chuan

AU - Chao, Che Yi

AU - Lin, Jing Jer

AU - Lo, Lee Chiang

AU - Kuo, Yueh Hsiung

PY - 2013/6

Y1 - 2013/6

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KW - Aconitamide

KW - Aconitum carmichaeli Debx.

KW - Anti-telomerase

KW - Chinese herb

KW - Ranunculaceae

KW - Roots

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Aconitamide, a novel alkaloid from the roots of Aconitum carmichaeli

Abstract

Keywords

ASJC Scopus subject areas

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