TY - JOUR
T1 - Accuracy of whole-body FDG-PET and FDG-PET/CT in M staging of nasopharyngeal carcinoma
T2 - A systematic review and meta-analysis
AU - Chang, Ming Che
AU - Chen, Jin Hua
AU - Liang, Ji An
AU - Yang, Kuang Tao
AU - Cheng, Kai Yuan
AU - Kao, Chia Hung
PY - 2013/2
Y1 - 2013/2
N2 - Background: A meta-analysis was conducted to evaluate the accuracy of whole-body positron emission tomography (PET) or PET/CT in M staging of nasopharyngeal carcinoma (NPC). Methods: Through a search of relevant English language studies from October 1996 to September 2011, pooled estimated sensitivity, specificity, positive likelihood ratios, negative likelihood ratios, and summary receiver operating characteristic (SROC) curves of whole-body PET or PET/CT in M staging of NPC were calculated. Results: Three PET and 5 PET/CT studies were identified. The pooled sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio of FDG-PET or PET/CT were 0.83 (95% confidence interval [CI], 0.77-0.88), 0.97 (95% CI, 0.95-0.98), 23.38 (95% CI, 16.22-33.69), and 0.19 (95% CI, 0.13-0.25), respectively. The area under curve was 0.9764 and Q* index estimate was 0.9307 for FDG-PET or PET/CT. Conclusion: Current evidence confirms the good diagnostic performance of the whole-body FDG-PET or PET/CT in M staging of NPC.
AB - Background: A meta-analysis was conducted to evaluate the accuracy of whole-body positron emission tomography (PET) or PET/CT in M staging of nasopharyngeal carcinoma (NPC). Methods: Through a search of relevant English language studies from October 1996 to September 2011, pooled estimated sensitivity, specificity, positive likelihood ratios, negative likelihood ratios, and summary receiver operating characteristic (SROC) curves of whole-body PET or PET/CT in M staging of NPC were calculated. Results: Three PET and 5 PET/CT studies were identified. The pooled sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio of FDG-PET or PET/CT were 0.83 (95% confidence interval [CI], 0.77-0.88), 0.97 (95% CI, 0.95-0.98), 23.38 (95% CI, 16.22-33.69), and 0.19 (95% CI, 0.13-0.25), respectively. The area under curve was 0.9764 and Q* index estimate was 0.9307 for FDG-PET or PET/CT. Conclusion: Current evidence confirms the good diagnostic performance of the whole-body FDG-PET or PET/CT in M staging of NPC.
KW - Meta-analysis
KW - Nasopharyngeal carcinoma
KW - PET
KW - PET/CT
KW - Staging
UR - http://www.scopus.com/inward/record.url?scp=84871920376&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84871920376&partnerID=8YFLogxK
U2 - 10.1016/j.ejrad.2012.06.031
DO - 10.1016/j.ejrad.2012.06.031
M3 - Article
C2 - 23083522
AN - SCOPUS:84871920376
SN - 0720-048X
VL - 82
SP - 366
EP - 373
JO - European Journal of Radiology
JF - European Journal of Radiology
IS - 2
ER -