Accumulation of 3-Monochloro-Propanediol Esters in Kidney Tissues of Patients with Human Renal Cell Carcinoma

Che Yuan Hu, Yu An Wang, Kai Wei Liao, Hung Tsung Wu, Chien Hui Ou, Choon Hui Tan, Wei Ju Lee

Research output: Contribution to journalArticlepeer-review

Abstract

Background: 3-Monochloro-propanediol esters (3-MCPDEs), commonly found in refined edible oils and related products, have generated concerns due to their nephrotoxicity and carcinogenicity, yet clinical evidence remains limited. Objectives: In this study, we aimed to assess, for the first time, the accumulation of 3-MCPDEs in human kidney tissues, focusing on 68 participants, some with and others without renal cell carcinoma (RCC). Methods: An analytical method for 3-MCPDE determination in kidney tissues underwent partial validation to ensure its suitability for sample analysis. The analyst was blind to the sample groups. Results: Results revealed significantly higher 3-MCPDE levels in RCC patients compared to non-RCC counterparts (0.22 vs. 0.01 µg/g) (p < 0.01). Moreover, no significant correlation was found between 3-MCPDE levels and tumor stage or size in the RCC group. Conclusions: Accumulation of 3-MCPDEs in humans, with significantly higher levels was observed in kidney tumor specimens compared to non-patients. These findings suggest minimizing the intake of 3-MCPD and its esters in diets in order to reduce potential negative health impacts.

Original languageEnglish
Article number3313
JournalCancers
Volume16
Issue number19
DOIs
Publication statusPublished - Oct 2024

Keywords

  • 3-MCPDEs
  • kidney
  • method validation
  • process contaminant
  • renal cell carcinoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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