A viral kinase mimics S6 kinase to enhance cell proliferation

Aadra Prashant Bhatt, Jason P. Wong, Marc S. Weinberg, Kurtis M. Host, Louise C. Giffin, Joshua Buijnink, Evert Van Dijk, Yoshihiro Izumiya, Hsing Jien Kung, Brenda R.S. Temple, Blossom Damania

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)


Viruses depend upon the host cell for manufacturing components of progeny virions. To mitigate the inextricable dependence on host cell protein synthesis, viruses can modulate protein synthesis through a variety of mechanisms. We report that the viral protein kinase (vPK) encoded by open reading frame 36 (ORF36) of Kaposi's sarcoma-associated herpesvirus (KSHV) enhances protein synthesis by mimicking the function of the cellular protein S6 kinase (S6KB1). Similar to S6KB1, vPK phosphorylates the ribosomal S6 protein and up-regulates global protein synthesis. vPK also augments cellular proliferation and anchorage-independent growth. Furthermore, we report that both vPK and S6KB1 phosphorylate the enzyme 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2 (PFKFB2) and that both kinases promote endothelial capillary tubule formation.

Original languageEnglish
Pages (from-to)7876-7881
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number28
Publication statusPublished - Jul 12 2016
Externally publishedYes


  • Cell signaling
  • KSHV
  • ORF36
  • S6K
  • Viral protein kinase

ASJC Scopus subject areas

  • General


Dive into the research topics of 'A viral kinase mimics S6 kinase to enhance cell proliferation'. Together they form a unique fingerprint.

Cite this