Abstract

Immunotherapy is one of the clinically effective cancer therapies. Developing an easy-to-use device for drug screening is an important issue. We presented a 3D microfluidic platform designed for in-vitro tumor-immune cell study. The biocompatible hydrogel with cells manipulated on the ITO electrode pattern without microstructure or pump. The device provides rapid in-vitro tumor establishment and long-term cell culture. In addition, the results showed T cells were infiltrated and colocalized with cancer cells in the device. These results indicated our microfluidic device had the potential to apply to cancer research and clinical drug screening.

Original languageEnglish
Title of host publicationMicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages346-347
Number of pages2
ISBN (Electronic)9781733419048
Publication statusPublished - 2022
Event26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2022 - Hybrid, Hangzhou, China
Duration: Oct 23 2022Oct 27 2022

Publication series

NameMicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2022
Country/TerritoryChina
CityHybrid, Hangzhou
Period10/23/2210/27/22

Keywords

  • 3D culture
  • GelMA
  • Immune cell
  • Infiltration
  • microfluidic platform

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering
  • General Chemistry
  • Control and Systems Engineering

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