A subpopulation of CD133+ cancer stem-like cells characterized in human oral squamous cell carcinoma confer resistance to chemotherapy

Qunzhou Zhang; Shihong Shi; Yun Yen; Jimmy Brown; Joseph Quoc Ta; Anh D. Le

doi:10.1016/j.canlet.2009.08.010

A subpopulation of CD133⁺ cancer stem-like cells characterized in human oral squamous cell carcinoma confer resistance to chemotherapy

Qunzhou Zhang
, Shihong Shi
, Yun Yen
, Jimmy Brown
, Joseph Quoc Ta
, Anh D. Le

Research output: Contribution to journal › Article › peer-review

230 Citations (Scopus)

Abstract

The potential role of cancer stem-like cells (CSCs) in chemoresistance of human oral squamous cell carcinoma (OSCC) was examined. A small subpopulation (1-2%) of CD133⁺ CSCs was identified in OSCC cell lines and tissues. These CD133⁺ CSCs possess higher clonogenicity, invasiveness, and increased in vivo tumorigenicity as compared to CD133^- counterparts. Meanwhile, CD133⁺ CSCs were substantially resistant to standard chemotherapy, wherein both in vitro and in vivo treatment with paclitaxel resulted in a marked enrichment for CD133⁺ CSCs. Our data suggest that CD133⁺ cells represent a small subpopulation of CSCs that may contribute to chemoresistance in human OSCC.

Original language	English
Pages (from-to)	151-160
Number of pages	10
Journal	Cancer Letters
Volume	289
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2009.08.010
Publication status	Published - Mar 28 2010
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

CD133 cancer stem-like cell
Chemoresistance
Oral squamous cell carcinoma

ASJC Scopus subject areas

Oncology
Cancer Research

Access to Document

10.1016/j.canlet.2009.08.010

Cite this

@article{8b888940d4544f9289c3a1e81f420628,

title = "A subpopulation of CD133+ cancer stem-like cells characterized in human oral squamous cell carcinoma confer resistance to chemotherapy",

abstract = "The potential role of cancer stem-like cells (CSCs) in chemoresistance of human oral squamous cell carcinoma (OSCC) was examined. A small subpopulation (1-2\%) of CD133+ CSCs was identified in OSCC cell lines and tissues. These CD133+ CSCs possess higher clonogenicity, invasiveness, and increased in vivo tumorigenicity as compared to CD133- counterparts. Meanwhile, CD133+ CSCs were substantially resistant to standard chemotherapy, wherein both in vitro and in vivo treatment with paclitaxel resulted in a marked enrichment for CD133+ CSCs. Our data suggest that CD133+ cells represent a small subpopulation of CSCs that may contribute to chemoresistance in human OSCC.",

keywords = "CD133 cancer stem-like cell, Chemoresistance, Oral squamous cell carcinoma",

author = "Qunzhou Zhang and Shihong Shi and Yun Yen and Jimmy Brown and Ta, \{Joseph Quoc\} and Le, \{Anh D.\}",

note = "Funding Information: This work was supported in part by National Institute of Health Research Grant, AR47359 (A. Le) and Oral and Maxillofacial Surgery Foundation (OMSF) Research Grant (Qunzhou Zhang and A. Le).",

year = "2010",

month = mar,

day = "28",

doi = "10.1016/j.canlet.2009.08.010",

language = "English",

volume = "289",

pages = "151--160",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "2",

}

TY - JOUR

T1 - A subpopulation of CD133+ cancer stem-like cells characterized in human oral squamous cell carcinoma confer resistance to chemotherapy

AU - Zhang, Qunzhou

AU - Shi, Shihong

AU - Yen, Yun

AU - Brown, Jimmy

AU - Ta, Joseph Quoc

AU - Le, Anh D.

N1 - Funding Information: This work was supported in part by National Institute of Health Research Grant, AR47359 (A. Le) and Oral and Maxillofacial Surgery Foundation (OMSF) Research Grant (Qunzhou Zhang and A. Le).

PY - 2010/3/28

Y1 - 2010/3/28

N2 - The potential role of cancer stem-like cells (CSCs) in chemoresistance of human oral squamous cell carcinoma (OSCC) was examined. A small subpopulation (1-2%) of CD133+ CSCs was identified in OSCC cell lines and tissues. These CD133+ CSCs possess higher clonogenicity, invasiveness, and increased in vivo tumorigenicity as compared to CD133- counterparts. Meanwhile, CD133+ CSCs were substantially resistant to standard chemotherapy, wherein both in vitro and in vivo treatment with paclitaxel resulted in a marked enrichment for CD133+ CSCs. Our data suggest that CD133+ cells represent a small subpopulation of CSCs that may contribute to chemoresistance in human OSCC.

AB - The potential role of cancer stem-like cells (CSCs) in chemoresistance of human oral squamous cell carcinoma (OSCC) was examined. A small subpopulation (1-2%) of CD133+ CSCs was identified in OSCC cell lines and tissues. These CD133+ CSCs possess higher clonogenicity, invasiveness, and increased in vivo tumorigenicity as compared to CD133- counterparts. Meanwhile, CD133+ CSCs were substantially resistant to standard chemotherapy, wherein both in vitro and in vivo treatment with paclitaxel resulted in a marked enrichment for CD133+ CSCs. Our data suggest that CD133+ cells represent a small subpopulation of CSCs that may contribute to chemoresistance in human OSCC.

KW - CD133 cancer stem-like cell

KW - Chemoresistance

KW - Oral squamous cell carcinoma

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DO - 10.1016/j.canlet.2009.08.010

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VL - 289

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