A Structured–Activity Relationship Study of Batracylin Analogues

Yilin Luo, Yun Feng Ren, Ting Chao Chou, Allan Y. Chen, Chiang Yu, Leroy F. Liu, C. C. Cheng

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)


A number of isoindolo[l ,2- b]quinazolines and some benzo[4,5]isoquinolino[l,2- b]quinazolines as structural modification analogues of the antitumor compound batracylin were synthesized and evaluated against HL-60 cell growth and in topoisomerase II-mediated DNA cleavage assays. Of the compounds studied, 10,12-dihydro-7,8-methy lenedioxyisoindolo[ 1,2- b] quinazolin-12(10 H)-one 1d, 2-amino-10,12-dihydroisoindolo[l ,2- b]quinazolin- 12(10 H)-one 1p, and 2-amino-7,8-methylenedioxy-10,12-dihydroisoindolo[l ,2- b]quinazolin-12(10 H)-one 1ab exhibited good inhibitory activities against HL-60 cell lines as well as induction of topo II-mediated DNA cleavage activities.

Original languageEnglish
Pages (from-to)918-923
Number of pages6
JournalPharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists
Issue number6
Publication statusPublished - Jun 1993
Externally publishedYes


  • DNA topoisomerase
  • colon adenocarcinoma 38
  • cytotoxicity
  • isoindolo[l,2- b]quinazolines
  • structure–activity relationship

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Molecular Medicine
  • Biotechnology
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry


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